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Protein

Glutamate--tRNA ligase 1

Gene

gltX1

Organism
Rhodobacter sphaeroides (strain ATCC 17025 / ATH 2.4.3)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei242ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRSPH349102:G1G8M-389-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligase 1UniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetase 1UniRule annotation
Short name:
GluRS 1UniRule annotation
Gene namesi
Name:gltX1UniRule annotation
Ordered Locus Names:Rsph17025_0382
OrganismiRhodobacter sphaeroides (strain ATCC 17025 / ATH 2.4.3)
Taxonomic identifieri349102 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRhodobacter
Proteomesi
  • UP000000234 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003677451 – 441Glutamate--tRNA ligase 1Add BLAST441

Proteomic databases

PRIDEiA4WPH4

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi349102.Rsph17025_0382

Structurei

3D structure databases

ProteinModelPortaliA4WPH4
SMRiA4WPH4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi9 – 19"HIGH" regionUniRule annotationAdd BLAST11
Motifi239 – 243"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C20 Bacteria
COG0008 LUCA
HOGENOMiHOG000252721
KOiK01885
OMAiLYPCYET
OrthoDBiPOG091H021W

Family and domain databases

Gene3Di1.10.10.350, 1 hit
3.40.50.620, 1 hit
HAMAPiMF_00022 Glu_tRNA_synth_type1, 1 hit
InterProiView protein in InterPro
IPR008925 aa-tRNA-synth_I_codon-bd
IPR020751 aa-tRNA-synth_I_codon-bd_sub2
IPR001412 aa-tRNA-synth_I_CS
IPR004527 Glu-tRNA-ligase_bac/mito
IPR000924 Glu/Gln-tRNA-synth
IPR020058 Glu/Gln-tRNA-synth_Ib_cat-dom
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF00749 tRNA-synt_1c, 1 hit
PRINTSiPR00987 TRNASYNTHGLU
SUPFAMiSSF48163 SSF48163, 1 hit
TIGRFAMsiTIGR00464 gltX_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

A4WPH4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTVTRFAPS PTGFIHVGNL RTALMNWAIA RKSGGTFILR LDDTDRERSK
60 70 80 90 100
QEYSDAIMQD LEWLGLTWDR LERQSDRLDR YAEAAGDLRR AGRFYECFES
110 120 130 140 150
PTELDLKRKK LLNMGKPPVY DRAALKLSDE DRARLREERG GYWRFLLDQE
160 170 180 190 200
RIEWTDGILG PISIDAASVS DPVLIRADGQ VLYTFASSVD DIDMGVTFIV
210 220 230 240 250
RGADHVTNTA TQIQIMQAMG GTPPSFAHHS LLTGAQGEAL SKRLGTLSLR
260 270 280 290 300
DLRARGVEPM ALLSLMARLG SSQPVELFRT HEELLAGFDV GTFGAAPTKF
310 320 330 340 350
DAEDLFPLTR HYVQGLPFEA VAERIRSLGV PDALAEPFWR VAKDNIAVLE
360 370 380 390 400
DLGGWWTLFS EGAEPQIDPE DADFIRQAMA LLPEPPYGPE TWGQWTAAVK
410 420 430 440
EATGRKGKGL FMPLRKALTG QAHGPEMADV MPLLQTVRAK G
Length:441
Mass (Da):49,046
Last modified:May 29, 2007 - v1
Checksum:i67190476E1D4564B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000661 Genomic DNA Translation: ABP69288.1
RefSeqiWP_011907442.1, NC_009428.1

Genome annotation databases

EnsemblBacteriaiABP69288; ABP69288; Rsph17025_0382
KEGGirsq:Rsph17025_0382

Similar proteinsi

Entry informationi

Entry nameiSYE1_RHOS5
AccessioniPrimary (citable) accession number: A4WPH4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: May 29, 2007
Last modified: May 23, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

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