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A4WPE6 (A4WPE6_RHOS5) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Serine hydroxymethyltransferase HAMAP MF_00051
Short name=SHMT HAMAP MF_00051
Short name=Serine methylase HAMAP MF_00051
EC=2.1.2.1 HAMAP MF_00051
Gene names
Name:glyA HAMAP MF_00051
Ordered Locus Names:Rsph17025_0354
OrganismRhodobacter sphaeroides (strain ATCC 17025 / ATH 2.4.3) [Complete proteome] [HAMAP]
Taxonomic identifier349102 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhodobacterales › Rhodobacteraceae › Rhodobacter

Protein attributes

Sequence length431 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Interconversion of serine and glycine By similarity. RuleBase RU000585 HAMAP MF_00051

Catalytic activity

5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine. RuleBase RU000585 HAMAP MF_00051

Cofactor

Pyridoxal phosphate By similarity. RuleBase RU000585 HAMAP MF_00051

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP MF_00051

One-carbon metabolism; tetrahydrofolate pathway. RuleBase RU000585

Subunit structure

Homotetramer By similarity. HAMAP MF_00051

Subcellular location

Cytoplasm By similarity HAMAP MF_00051.

Sequence similarities

Belongs to the SHMT family. RuleBase RU004104 HAMAP MF_00051

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Amino acid modifications

Modified residue2371N6-(pyridoxal phosphate)lysine By similarity HAMAP MF_00051

Sequences

Sequence LengthMass (Da)Tools
A4WPE6 [UniParc].

Last modified May 29, 2007. Version 1.
Checksum: C94272BF404A8309

FASTA43145,991
        10         20         30         40         50         60 
MNAPHRDDGF FTESLSSRDP ELFASITGEL GRQRDEIELI ASENIVSRAV MEAQGSVMTN 

        70         80         90        100        110        120 
KYAEGYPGKR YYGGCDYVDV AETLAIERAK QLFGCAFANV QPNSGSQANQ GVFQALIKPG 

       130        140        150        160        170        180 
DTILGMELAS GGHLTHGAAP NQSGKWFHAV QYGVRQQDQR IDYDQVAALA REHKPRLIIA 

       190        200        210        220        230        240 
GGSAIPRQID FAKFRAIADE VGAWLMVDMA HFAGLVAGGA HPSPFPYADV ATTTTHKTLR 

       250        260        270        280        290        300 
GPRGGMILTN NEEIAKKVNS AIFPGIQGGP LMHVIAAKAV AFGEALRPEF KAYAAQVVKN 

       310        320        330        340        350        360 
AQALADELMK GGLDIVTGGT DTHVMLVDLR PKGVKGNATE KALGRAHITC NKNGIPFDPE 

       370        380        390        400        410        420 
KPMVTSGVRL GTPAGTTRGF GEEEFREIGR LIVEVVDGLA AHGEEGNAAV EEAVKAKVAA 

       430 
LCARFPLYPT L

« Hide

References

[1]"Complete sequence of chromosome of Rhodobacter sphaeroides ATCC 17025."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Kim E., Richardson P., Mackenzie C., Choudhary M., Donohue T.J., Kaplan S.
Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 17025 / ATH 2.4.3.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000661 Genomic DNA. Translation: ABP69260.1.
RefSeqYP_001166565.1. NC_009428.1.

3D structure databases

ProteinModelPortalA4WPE6.
ModBaseSearch...

Protein-protein interaction databases

STRINGA4WPE6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5082621.
GenomeReviewsGene locus Rsph17025_0354 in contig CP000661_GR.
KEGGrsq:Rsph17025_0354.
PATRIC23158826. VBIRhoSph94549_0356.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0112.
HOGENOMHBG301263.
OMAIFNAGYA.
PhylomeDBA4WPE6.
ProtClustDBPRK00011.

Enzyme and pathway databases

BioCycRSPH349102:RSPH17025_0354-MONOMER.

Family and domain databases

HAMAPMF_00051. SHMT.
[Tree]
InterProIPR015424. PyrdxlP-dep_Trfase_major_dom.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR001085. Ser_HO-MeTrfase.
IPR019798. Ser_HO-MeTrfase_PLP_BS.
[Graphical view]
Gene3DG3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 1 hit.
KOK00600.
PANTHERPTHR11680. Gly_HO-Metrfase. 1 hit.
PfamPF00464. SHMT. 1 hit.
[Graphical view]
PIRSFPIRSF000412. SHMT. 1 hit.
SUPFAMSSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
PROSITEPS00096. SHMT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA4WPE6_RHOS5
AccessionPrimary (citable) accession number: A4WPE6
Entry history
Integrated into UniProtKB/TrEMBL: May 29, 2007
Last sequence update: May 29, 2007
Last modified: December 14, 2011
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info