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A4WPE5

- NADK_RHOS5

UniProt

A4WPE5 - NADK_RHOS5

Protein

NAD kinase

Gene

nadK

Organism
Rhodobacter sphaeroides (strain ATCC 17025 / ATH 2.4.3)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (29 May 2007)
      Previous versions | rss
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    Functioni

    Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

    Catalytic activityi

    ATP + NAD+ = ADP + NADP+.UniRule annotation

    Cofactori

    Divalent metal ions.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei44 – 441Proton acceptorUniRule annotation
    Binding sitei144 – 1441NADUniRule annotation
    Binding sitei152 – 1521NAD; via carbonyl oxygenUniRule annotation
    Binding sitei179 – 1791NAD; via carbonyl oxygenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi44 – 452NADUniRule annotation
    Nucleotide bindingi114 – 1152NADUniRule annotation
    Nucleotide bindingi155 – 1606NADUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-HAMAP
    3. NAD+ kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. NAD metabolic process Source: InterPro
    2. NADP biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, NAD, NADP, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciRSPH349102:GHE1-1682-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
    Alternative name(s):
    ATP-dependent NAD kinaseUniRule annotation
    Gene namesi
    Name:nadKUniRule annotation
    Ordered Locus Names:Rsph17025_0353
    OrganismiRhodobacter sphaeroides (strain ATCC 17025 / ATH 2.4.3)
    Taxonomic identifieri349102 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRhodobacter
    ProteomesiUP000000234: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 254254NAD kinasePRO_1000005436Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi349102.Rsph17025_0353.

    Structurei

    3D structure databases

    ProteinModelPortaliA4WPE5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAD kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0061.
    HOGENOMiHOG000139847.
    KOiK00858.
    OMAiHESTVSI.
    OrthoDBiEOG6PZXDR.

    Family and domain databases

    Gene3Di2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPiMF_00361. NAD_kinase.
    InterProiIPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view]
    PANTHERiPTHR20275. PTHR20275. 1 hit.
    PfamiPF01513. NAD_kinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF111331. SSF111331. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A4WPE5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTPQRIGFVA SPAPVAQEAL VAMEARYGQC PLPEAEVIVA LGGDGFMLQT    50
    LHETQSLDIP VYGMNRGTVG FLMNGYAGDG LRERLAEAEE EILNPLVMTA 100
    VTEAGEVFHR IAINEVSLLR AGPQAAWLKI SVDGKVRMEE LVCDGALVCT 150
    PAGSTAYNYS AHGPILPIGA DVLALTAIAP FRPRRWRGAL LPKTATVRFD 200
    VIDARKRPVM ADADGRSVRD VVSVEVRSEP AIRHRLLFDP GHGLEERLIR 250
    EQFV 254
    Length:254
    Mass (Da):27,592
    Last modified:May 29, 2007 - v1
    Checksum:i0943FBDA62A5136D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000661 Genomic DNA. Translation: ABP69259.1.
    RefSeqiWP_011907413.1. NC_009428.1.
    YP_001166564.1. NC_009428.1.

    Genome annotation databases

    EnsemblBacteriaiABP69259; ABP69259; Rsph17025_0353.
    GeneIDi5082620.
    KEGGirsq:Rsph17025_0353.
    PATRICi23158824. VBIRhoSph94549_0355.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000661 Genomic DNA. Translation: ABP69259.1 .
    RefSeqi WP_011907413.1. NC_009428.1.
    YP_001166564.1. NC_009428.1.

    3D structure databases

    ProteinModelPortali A4WPE5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 349102.Rsph17025_0353.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABP69259 ; ABP69259 ; Rsph17025_0353 .
    GeneIDi 5082620.
    KEGGi rsq:Rsph17025_0353.
    PATRICi 23158824. VBIRhoSph94549_0355.

    Phylogenomic databases

    eggNOGi COG0061.
    HOGENOMi HOG000139847.
    KOi K00858.
    OMAi HESTVSI.
    OrthoDBi EOG6PZXDR.

    Enzyme and pathway databases

    BioCyci RSPH349102:GHE1-1682-MONOMER.

    Family and domain databases

    Gene3Di 2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPi MF_00361. NAD_kinase.
    InterProi IPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view ]
    PANTHERi PTHR20275. PTHR20275. 1 hit.
    Pfami PF01513. NAD_kinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF111331. SSF111331. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 17025 / ATH 2.4.3.

    Entry informationi

    Entry nameiNADK_RHOS5
    AccessioniPrimary (citable) accession number: A4WPE5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: May 29, 2007
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3