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A4WPE5

- NADK_RHOS5

UniProt

A4WPE5 - NADK_RHOS5

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Protein
NAD kinase
Gene
nadK, Rsph17025_0353
Organism
Rhodobacter sphaeroides (strain ATCC 17025 / ATH 2.4.3)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP By similarity.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

Divalent metal ions By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei44 – 441Proton acceptor By similarity
Binding sitei144 – 1441NAD By similarity
Binding sitei152 – 1521NAD; via carbonyl oxygen By similarity
Binding sitei179 – 1791NAD; via carbonyl oxygen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi44 – 452NAD By similarity
Nucleotide bindingi114 – 1152NAD By similarity
Nucleotide bindingi155 – 1606NAD By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. NAD+ kinase activity Source: UniProtKB-HAMAP
  3. metal ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. NAD metabolic process Source: InterPro
  2. NADP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciRSPH349102:GHE1-1682-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinase (EC:2.7.1.23)
Alternative name(s):
ATP-dependent NAD kinase
Gene namesi
Name:nadK
Ordered Locus Names:Rsph17025_0353
OrganismiRhodobacter sphaeroides (strain ATCC 17025 / ATH 2.4.3)
Taxonomic identifieri349102 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRhodobacter
ProteomesiUP000000234: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 254254NAD kinaseUniRule annotation
PRO_1000005436Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi349102.Rsph17025_0353.

Structurei

3D structure databases

ProteinModelPortaliA4WPE5.

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.

Phylogenomic databases

eggNOGiCOG0061.
HOGENOMiHOG000139847.
KOiK00858.
OMAiHESTVSI.
OrthoDBiEOG6PZXDR.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

A4WPE5-1 [UniParc]FASTAAdd to Basket

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MTPQRIGFVA SPAPVAQEAL VAMEARYGQC PLPEAEVIVA LGGDGFMLQT    50
LHETQSLDIP VYGMNRGTVG FLMNGYAGDG LRERLAEAEE EILNPLVMTA 100
VTEAGEVFHR IAINEVSLLR AGPQAAWLKI SVDGKVRMEE LVCDGALVCT 150
PAGSTAYNYS AHGPILPIGA DVLALTAIAP FRPRRWRGAL LPKTATVRFD 200
VIDARKRPVM ADADGRSVRD VVSVEVRSEP AIRHRLLFDP GHGLEERLIR 250
EQFV 254
Length:254
Mass (Da):27,592
Last modified:May 29, 2007 - v1
Checksum:i0943FBDA62A5136D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000661 Genomic DNA. Translation: ABP69259.1.
RefSeqiWP_011907413.1. NC_009428.1.
YP_001166564.1. NC_009428.1.

Genome annotation databases

EnsemblBacteriaiABP69259; ABP69259; Rsph17025_0353.
GeneIDi5082620.
KEGGirsq:Rsph17025_0353.
PATRICi23158824. VBIRhoSph94549_0355.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000661 Genomic DNA. Translation: ABP69259.1 .
RefSeqi WP_011907413.1. NC_009428.1.
YP_001166564.1. NC_009428.1.

3D structure databases

ProteinModelPortali A4WPE5.
ModBasei Search...

Protein-protein interaction databases

STRINGi 349102.Rsph17025_0353.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABP69259 ; ABP69259 ; Rsph17025_0353 .
GeneIDi 5082620.
KEGGi rsq:Rsph17025_0353.
PATRICi 23158824. VBIRhoSph94549_0355.

Phylogenomic databases

eggNOGi COG0061.
HOGENOMi HOG000139847.
KOi K00858.
OMAi HESTVSI.
OrthoDBi EOG6PZXDR.

Enzyme and pathway databases

BioCyci RSPH349102:GHE1-1682-MONOMER.

Family and domain databases

Gene3Di 2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPi MF_00361. NAD_kinase.
InterProi IPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view ]
PANTHERi PTHR20275. PTHR20275. 1 hit.
Pfami PF01513. NAD_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 17025 / ATH 2.4.3.

Entry informationi

Entry nameiNADK_RHOS5
AccessioniPrimary (citable) accession number: A4WPE5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 29, 2007
Last modified: September 3, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi