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Protein

Glutamate-1-semialdehyde 2,1-aminomutase

Gene

hemL

Organism
Pyrobaculum arsenaticum (strain DSM 13514 / JCM 11321)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: protoporphyrin-IX biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes 5-aminolevulinate from L-glutamyl-tRNA(Glu).UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Glutamyl-tRNA reductase 1 (hemA1), Glutamyl-tRNA reductase 2 (hemA2)
  2. Glutamate-1-semialdehyde 2,1-aminomutase (hemL)
This subpathway is part of the pathway protoporphyrin-IX biosynthesis, which is itself part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-aminolevulinate from L-glutamyl-tRNA(Glu), the pathway protoporphyrin-IX biosynthesis and in Porphyrin-containing compound metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processPorphyrin biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00251; UER00317

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutaseUniRule annotation (EC:5.4.3.8UniRule annotation)
Short name:
GSAUniRule annotation
Alternative name(s):
Glutamate-1-semialdehyde aminotransferaseUniRule annotation
Short name:
GSA-ATUniRule annotation
Gene namesi
Name:hemLUniRule annotation
Ordered Locus Names:Pars_2254
OrganismiPyrobaculum arsenaticum (strain DSM 13514 / JCM 11321)
Taxonomic identifieri340102 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaePyrobaculum
Proteomesi
  • UP000001567 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003824111 – 423Glutamate-1-semialdehyde 2,1-aminomutaseAdd BLAST423

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei258N6-(pyridoxal phosphate)lysineUniRule annotation1

Structurei

3D structure databases

ProteinModelPortaliA4WN33
SMRiA4WN33
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000020210
KOiK01845
OMAiWGPLIFG
OrthoDBiPOG093Z024H

Family and domain databases

CDDicd00610 OAT_like, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_00375 HemL_aminotrans_3, 1 hit
InterProiView protein in InterPro
IPR004639 4pyrrol_synth_GluAld_NH2Trfase
IPR005814 Aminotrans_3
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00202 Aminotran_3, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR00713 hemL, 1 hit
PROSITEiView protein in PROSITE
PS00600 AA_TRANSFER_CLASS_3, 1 hit

Sequencei

Sequence statusi: Complete.

A4WN33-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLFERARQVF PGGVNSPARA LKHLPSSLVA RAASGPYLYT DRGRLVDYCM
60 70 80 90 100
AFGAIILGHA HPRVKRAVEE QLERGWIYAL LTEQEVEFAE AIRRHMPSVE
110 120 130 140 150
KMRIVNTGTE ATMNAIRLAR GYTKRDVIIK FDGNFHGSHD YVLVKAGSGA
160 170 180 190 200
ATWGIPTSAG VPQDVVKLTV VAPYNDVDAF LKAVKEVGDR LAAVIAEPVA
210 220 230 240 250
GNYGLIIPDA EFLKALREET KRVGALLIFD EVITGFRLGL GGAQGRFGIR
260 270 280 290 300
PDLTTLGKAV GGGFPIGIFG GRAEVMDLVA PSGPVYNAGT YNAHPVSVTA
310 320 330 340 350
GLAVLKELET GEPFRTADEA AERLAKGIED IAGRLGFDVV VKKIASMFQF
360 370 380 390 400
YFKKGDVKTP QDVRESNEKM YLKLHEIALR HGVYLTPSQF EVNFTSAAHT
410 420
REVVEETLAA LEKAFQQLKT EIG
Length:423
Mass (Da):46,055
Last modified:May 29, 2007 - v1
Checksum:iA5EAFB304C3B3F60
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000660 Genomic DNA Translation: ABP51800.1

Genome annotation databases

EnsemblBacteriaiABP51800; ABP51800; Pars_2254
KEGGipas:Pars_2254

Similar proteinsi

Entry informationi

Entry nameiGSA_PYRAR
AccessioniPrimary (citable) accession number: A4WN33
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: May 29, 2007
Last modified: June 20, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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