A4WN19 (TRPC_PYRAR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Indole-3-glycerol phosphate synthase
Short name=IGPS
EC=4.1.1.48

Gene names

Name:	trpC
Ordered Locus Names:	Pars_2240

Organism

Pyrobaculum arsenaticum (strain DSM 13514 / JCM 11321) [Complete proteome] [HAMAP]

Taxonomic identifier

340102 [NCBI]

Taxonomic lineage

Archaea › Crenarchaeota › Thermoprotei › Thermoproteales › Thermoproteaceae › Pyrobaculum

Protein attributes

Sequence length	249 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O. HAMAP MF_00134_A
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5. HAMAP MF_00134_A
Sequence similarities	Belongs to the TrpC family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tryptophan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	indole-3-glycerol-phosphate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 249	249	Indole-3-glycerol phosphate synthase HAMAP MF_00134_A		PRO_1000198792

Sequences

	Sequence		Length	Mass (Da)
	A4WN19 [UniParc]. Last modified May 29, 2007. Version 1. Checksum: 6C962E2BDAD3BC6C	FASTA	249	27,726
	10 20 30 40 50 60 MDFLAQVKKA VELRLATEPS PPARSLPLVD FSKALGEFGI IAEYKRASPR GVVRLDMPPW 70 80 90 100 110 120 AYFAMLQPYA AAFSVLTEPY WFLGDYRFIT MAKPFKPVLM KDFVIDNRQI DMAYGYGADA 130 140 150 160 170 180 VLIIYRLVGR EKAMELAEYA QRLGLTPVVE VDNLQDAKEA ATWGGKVMLG INARDLATLE 190 200 210 220 230 240 VSLQKAFEIA KALRGDVDFI IESGISKPEE VEKACMLYAR GVLVGTALMK NPALIKELRH AAESCVSRR

References

[1]

"Complete sequence of Pyrobaculum arsenaticum DSM 13514." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N. , Cozen A.E., Fitz-Gibbon S.T., House C.H., Saltikov C., Lowe T.M., Richardson P. Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 13514 / JCM 11321.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000660 Genomic DNA. Translation: ABP51786.1.
RefSeq	YP_001154438.1. NC_009376.1.
3D structure databases
ProteinModelPortal	A4WN19.
ModBase	Search...
Protein-protein interaction databases
STRING	A4WN19.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5054941.
GenomeReviews	Gene locus Pars_2240 in contig CP000660_GR.
KEGG	pas:Pars_2240.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	arNOG04622.
HOGENOM	HBG540956.
OMA	FFPEQVK.
ProtClustDB	CLSK899510.
Enzyme and pathway databases
BioCyc	PARS340102:PARS_2240-MONOMER.
Family and domain databases
HAMAP	MF_00134_A. IGPS_A. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR013798. Indole-3-glycerol_P_synth. IPR001468. Indole-3-GlycerolPSynthase_CS. IPR011060. RibuloseP-bd_barrel. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01609.
Pfam	PF00218. IGPS. 1 hit. [Graphical view]
SUPFAM	SSF51366. RibP_bind_barrel. 1 hit.
PROSITE	PS00614. IGPS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TRPC_PYRAR

Accession

Primary (citable) accession number: A4WN19

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	May 29, 2007
Last modified:	January 25, 2012
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program