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A4WMP8 (AROC_PYRAR) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Chorismate synthase
EC=4.2.3.5
Alternative name(s):
5-enolpyruvylshikimate-3-phosphate phospholyase
Gene names
Name:aroC
Ordered Locus Names:Pars_2119
OrganismPyrobaculum arsenaticum (strain DSM 13514 / JCM 11321) [Complete proteome] [HAMAP]
Taxonomic identifier340102 [NCBI]
Taxonomic lineageArchaea › Crenarchaeota › Thermoprotei › Thermoproteales › Thermoproteaceae › Pyrobaculum

Protein attributes

Sequence length368 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate. HAMAP MF_00300

Cofactor

Reduced flavin By similarity. HAMAP MF_00300

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7. HAMAP MF_00300

Sequence similarities

Belongs to the chorismate synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionchorismate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 368368Chorismate synthase HAMAP MF_00300
PRO_0000322436

Sequences

Sequence LengthMass (Da)Tools
A4WMP8 [UniParc].

Last modified May 29, 2007. Version 1.
Checksum: D60C6F60018B3DB2

FASTA36839,923
        10         20         30         40         50         60 
MNTFGRELRI TTFGESHGRA IGVVIDGVPA GLPLTEEDIR KELDRRMFCH IHWLNPRCEP 

        70         80         90        100        110        120 
EEFEILSGVK DGHTQGTPIA IVIWNKKAIS SYYDELWMKP RPGHADLAYY LKYGKFYDHR 

       130        140        150        160        170        180 
GGGRASGRTT AAIVAAGAVA KKLLALVGAE VAGHIVELGG VEVKRPYTFE DVKKSWEKPL 

       190        200        210        220        230        240 
PVVDDDALAA MLEVLRKNAA EGDSVGGGVE IWAVGVPQGL GEPHFGKIRA DLAHAAFSVP 

       250        260        270        280        290        300 
AVVALDWGAG RQLAKMRGSE ANDPIVVKGG KPGLETNKIG GVLGGITIGE PLYFRVWLKP 

       310        320        330        340        350        360 
TPSVRKPQRT VDLAKMEPAT LQFKGRYDVS VVPKALVALE AMTAITLADH LLRAGVIRRD 


RPLKDPVV

« Hide

References

[1]"Complete sequence of Pyrobaculum arsenaticum DSM 13514."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N. expand/collapse author list , Cozen A.E., Fitz-Gibbon S.T., House C.H., Saltikov C., Lowe T.M., Richardson P.
Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 13514 / JCM 11321.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000660 Genomic DNA. Translation: ABP51665.1.
RefSeqYP_001154317.1. NC_009376.1.

3D structure databases

ProteinModelPortalA4WMP8.
ModBaseSearch...

Protein-protein interaction databases

STRINGA4WMP8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5055775.
GenomeReviewsGene locus Pars_2119 in contig CP000660_GR.
KEGGpas:Pars_2119.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGarNOG04618.
HOGENOMHBG292336.
OMASRFTTQR.
PhylomeDBA4WMP8.
ProtClustDBPRK05382.

Enzyme and pathway databases

BioCycPARS340102:PARS_2119-MONOMER.

Family and domain databases

HAMAPMF_00300. Chorismate_synth.
[Tree]
InterProIPR000453. Chorismate_synth.
IPR020541. Chorismate_synthase_CS.
[Graphical view]
KOK01736.
PANTHERPTHR21085. Chorismate_synth. 1 hit.
PfamPF01264. Chorismate_synt. 1 hit.
[Graphical view]
PIRSFPIRSF001456. Chorismate_synth. 1 hit.
SUPFAMSSF103263. Chorismate_synth. 1 hit.
TIGRFAMsTIGR00033. AroC. 1 hit.
PROSITEPS00787. CHORISMATE_SYNTHASE_1. 1 hit.
PS00788. CHORISMATE_SYNTHASE_2. 1 hit.
PS00789. CHORISMATE_SYNTHASE_3. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAROC_PYRAR
AccessionPrimary (citable) accession number: A4WMP8
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: May 29, 2007
Last modified: January 25, 2012
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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