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A4WMA6

- TF2B_PYRAR

UniProt

A4WMA6 - TF2B_PYRAR

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Protein

Transcription initiation factor IIB

Gene
tfb, Pars_1976
Organism
Pyrobaculum arsenaticum (strain DSM 13514 / JCM 11321)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB) By similarity.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi37 – 371Zinc By similarity
Metal bindingi40 – 401Zinc By similarity
Metal bindingi56 – 561Zinc By similarity
Metal bindingi59 – 591Zinc By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri33 – 6432TFIIB-typeUniRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding transcription factor activity Source: UniProtKB-HAMAP
  2. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA-templated transcription, initiation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciPARS340102:GHGQ-2005-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription initiation factor IIB
Short name:
TFIIB
Gene namesi
Name:tfb
Ordered Locus Names:Pars_1976
OrganismiPyrobaculum arsenaticum (strain DSM 13514 / JCM 11321)
Taxonomic identifieri340102 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaePyrobaculum
ProteomesiUP000001567: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 333333Transcription initiation factor IIBUniRule annotationPRO_1000080115Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi340102.Pars_1976.

Structurei

3D structure databases

ProteinModelPortaliA4WMA6.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati149 – 232841UniRule annotationAdd
BLAST
Repeati243 – 324822UniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the TFIIB family.

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri33 – 6432TFIIB-typeUniRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG1405.
HOGENOMiHOG000108633.
KOiK03124.
OMAiCDSQNIS.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
HAMAPiMF_00383. TF2B_arch.
InterProiIPR013763. Cyclin-like.
IPR000812. TFIIB.
IPR023484. TFIIB_arc.
IPR023486. TFIIB_CS.
IPR013150. TFIIB_cyclin.
IPR013137. Znf_TFIIB.
[Graphical view]
PANTHERiPTHR11618. PTHR11618. 1 hit.
PfamiPF08271. TF_Zn_Ribbon. 1 hit.
PF00382. TFIIB. 2 hits.
[Graphical view]
PRINTSiPR00685. TIFACTORIIB.
SMARTiSM00385. CYCLIN. 2 hits.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
PROSITEiPS00782. TFIIB. 2 hits.
PS51134. ZF_TFIIB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4WMA6-1 [UniParc]FASTAAdd to Basket

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MSSTSLPSSG KPLKLRINRD SEGYLSLVTE SGEIYRCPIC GNDRFVYNYE    50
RGEVVCIVCG AVVQEQLLDL GPEWRAFTSE EKGQRARTGA PLTRLISEAL 100
TTVIDWRDKD VSGRELDIKR KLEVIRLRKW QTRARVQTSY ERNFIQAAQE 150
LERLKSSMGV PRPCVEQALE IYRQALEKEL VRGRSVEAMA AAALYMACRM 200
MRMPRPLDEL VRYTKASRRE VARCYRLLLR ELNVKVPISD PVLYISRIAE 250
QLKLSGEVVK AAIDILQRAK KAGITAGKDP AGLAAAAVYI ASLMHGDNRT 300
QKDFAVAAGV TEVTVRNRYK ELAKALNIKV PVK 333
Length:333
Mass (Da):37,473
Last modified:May 29, 2007 - v1
Checksum:i9D31DB6955D05AE7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000660 Genomic DNA. Translation: ABP51523.1.
RefSeqiWP_011901428.1. NC_009376.1.
YP_001154175.1. NC_009376.1.

Genome annotation databases

EnsemblBacteriaiABP51523; ABP51523; Pars_1976.
GeneIDi5054452.
KEGGipas:Pars_1976.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000660 Genomic DNA. Translation: ABP51523.1 .
RefSeqi WP_011901428.1. NC_009376.1.
YP_001154175.1. NC_009376.1.

3D structure databases

ProteinModelPortali A4WMA6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 340102.Pars_1976.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABP51523 ; ABP51523 ; Pars_1976 .
GeneIDi 5054452.
KEGGi pas:Pars_1976.

Phylogenomic databases

eggNOGi COG1405.
HOGENOMi HOG000108633.
KOi K03124.
OMAi CDSQNIS.

Enzyme and pathway databases

BioCyci PARS340102:GHGQ-2005-MONOMER.

Family and domain databases

Gene3Di 1.10.472.10. 2 hits.
HAMAPi MF_00383. TF2B_arch.
InterProi IPR013763. Cyclin-like.
IPR000812. TFIIB.
IPR023484. TFIIB_arc.
IPR023486. TFIIB_CS.
IPR013150. TFIIB_cyclin.
IPR013137. Znf_TFIIB.
[Graphical view ]
PANTHERi PTHR11618. PTHR11618. 1 hit.
Pfami PF08271. TF_Zn_Ribbon. 1 hit.
PF00382. TFIIB. 2 hits.
[Graphical view ]
PRINTSi PR00685. TIFACTORIIB.
SMARTi SM00385. CYCLIN. 2 hits.
[Graphical view ]
SUPFAMi SSF47954. SSF47954. 2 hits.
PROSITEi PS00782. TFIIB. 2 hits.
PS51134. ZF_TFIIB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 13514 / JCM 11321.

Entry informationi

Entry nameiTF2B_PYRAR
AccessioniPrimary (citable) accession number: A4WMA6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 29, 2007
Last modified: September 3, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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