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A4WMA6 (TF2B_PYRAR) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transcription initiation factor IIB

Short name=TFIIB
Gene names
Name:tfb
Ordered Locus Names:Pars_1976
OrganismPyrobaculum arsenaticum (strain DSM 13514 / JCM 11321) [Complete proteome] [HAMAP]
Taxonomic identifier340102 [NCBI]
Taxonomic lineageArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaePyrobaculum

Protein attributes

Sequence length333 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB) By similarity. HAMAP-Rule MF_00383

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP-Rule MF_00383

Sequence similarities

Belongs to the TFIIB family.

Contains 1 TFIIB-type zinc finger.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 333333Transcription initiation factor IIB HAMAP-Rule MF_00383
PRO_1000080115

Regions

Repeat149 – 232841 HAMAP-Rule MF_00383
Repeat243 – 324822 HAMAP-Rule MF_00383
Zinc finger33 – 6432TFIIB-type HAMAP-Rule MF_00383

Sites

Metal binding371Zinc By similarity
Metal binding401Zinc By similarity
Metal binding561Zinc By similarity
Metal binding591Zinc By similarity

Sequences

Sequence LengthMass (Da)Tools
A4WMA6 [UniParc].

Last modified May 29, 2007. Version 1.
Checksum: 9D31DB6955D05AE7

FASTA33337,473
        10         20         30         40         50         60 
MSSTSLPSSG KPLKLRINRD SEGYLSLVTE SGEIYRCPIC GNDRFVYNYE RGEVVCIVCG 

        70         80         90        100        110        120 
AVVQEQLLDL GPEWRAFTSE EKGQRARTGA PLTRLISEAL TTVIDWRDKD VSGRELDIKR 

       130        140        150        160        170        180 
KLEVIRLRKW QTRARVQTSY ERNFIQAAQE LERLKSSMGV PRPCVEQALE IYRQALEKEL 

       190        200        210        220        230        240 
VRGRSVEAMA AAALYMACRM MRMPRPLDEL VRYTKASRRE VARCYRLLLR ELNVKVPISD 

       250        260        270        280        290        300 
PVLYISRIAE QLKLSGEVVK AAIDILQRAK KAGITAGKDP AGLAAAAVYI ASLMHGDNRT 

       310        320        330 
QKDFAVAAGV TEVTVRNRYK ELAKALNIKV PVK 

« Hide

References

[1]"Complete sequence of Pyrobaculum arsenaticum DSM 13514."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N. expand/collapse author list , Cozen A.E., Fitz-Gibbon S.T., House C.H., Saltikov C., Lowe T.M., Richardson P.
Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 13514 / JCM 11321.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000660 Genomic DNA. Translation: ABP51523.1.
RefSeqYP_001154175.1. NC_009376.1.

3D structure databases

ProteinModelPortalA4WMA6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING340102.Pars_1976.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABP51523; ABP51523; Pars_1976.
GeneID5054452.
KEGGpas:Pars_1976.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1405.
HOGENOMHOG000108633.
KOK03124.
OMAVLRWRKW.
ProtClustDBPRK00423.

Enzyme and pathway databases

BioCycPARS340102:GHGQ-2005-MONOMER.

Family and domain databases

Gene3D1.10.472.10. 2 hits.
HAMAPMF_00383. TF2B_arch.
InterProIPR013763. Cyclin-like.
IPR000812. TFIIB.
IPR023484. TFIIB_arc.
IPR023486. TFIIB_CS.
IPR013150. TFIIB_cyclin.
IPR013137. Znf_TFIIB.
[Graphical view]
PANTHERPTHR11618. PTHR11618. 1 hit.
PfamPF08271. TF_Zn_Ribbon. 1 hit.
PF00382. TFIIB. 2 hits.
[Graphical view]
PRINTSPR00685. TIFACTORIIB.
SMARTSM00385. CYCLIN. 2 hits.
[Graphical view]
SUPFAMSSF47954. SSF47954. 2 hits.
PROSITEPS00782. TFIIB. 2 hits.
PS51134. ZF_TFIIB. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTF2B_PYRAR
AccessionPrimary (citable) accession number: A4WMA6
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 29, 2007
Last modified: February 19, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families