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Protein

Transcription initiation factor IIB

Gene

tfb

Organism
Pyrobaculum arsenaticum (strain DSM 13514 / JCM 11321)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi37 – 371ZincUniRule annotation
Metal bindingi40 – 401ZincUniRule annotation
Metal bindingi56 – 561ZincUniRule annotation
Metal bindingi59 – 591ZincUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri33 – 6432TFIIB-typeUniRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciPARS340102:GHGQ-2005-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription initiation factor IIBUniRule annotation
Short name:
TFIIBUniRule annotation
Gene namesi
Name:tfbUniRule annotation
Ordered Locus Names:Pars_1976
OrganismiPyrobaculum arsenaticum (strain DSM 13514 / JCM 11321)
Taxonomic identifieri340102 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaePyrobaculum
ProteomesiUP000001567 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 333333Transcription initiation factor IIBPRO_1000080115Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliA4WMA6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati149 – 232841Add
BLAST
Repeati243 – 324822Add
BLAST

Sequence similaritiesi

Belongs to the TFIIB family.UniRule annotation
Contains 1 TFIIB-type zinc finger.UniRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri33 – 6432TFIIB-typeUniRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG1405.
HOGENOMiHOG000108633.
KOiK03124.
OMAiWRAFDHD.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
HAMAPiMF_00383. TF2B_arch.
InterProiIPR013763. Cyclin-like.
IPR000812. TFIIB.
IPR023484. TFIIB_arc.
IPR023486. TFIIB_CS.
IPR013150. TFIIB_cyclin.
IPR013137. Znf_TFIIB.
[Graphical view]
PANTHERiPTHR11618. PTHR11618. 1 hit.
PfamiPF08271. TF_Zn_Ribbon. 1 hit.
PF00382. TFIIB. 2 hits.
[Graphical view]
PRINTSiPR00685. TIFACTORIIB.
SMARTiSM00385. CYCLIN. 2 hits.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
PROSITEiPS00782. TFIIB. 2 hits.
PS51134. ZF_TFIIB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4WMA6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSTSLPSSG KPLKLRINRD SEGYLSLVTE SGEIYRCPIC GNDRFVYNYE
60 70 80 90 100
RGEVVCIVCG AVVQEQLLDL GPEWRAFTSE EKGQRARTGA PLTRLISEAL
110 120 130 140 150
TTVIDWRDKD VSGRELDIKR KLEVIRLRKW QTRARVQTSY ERNFIQAAQE
160 170 180 190 200
LERLKSSMGV PRPCVEQALE IYRQALEKEL VRGRSVEAMA AAALYMACRM
210 220 230 240 250
MRMPRPLDEL VRYTKASRRE VARCYRLLLR ELNVKVPISD PVLYISRIAE
260 270 280 290 300
QLKLSGEVVK AAIDILQRAK KAGITAGKDP AGLAAAAVYI ASLMHGDNRT
310 320 330
QKDFAVAAGV TEVTVRNRYK ELAKALNIKV PVK
Length:333
Mass (Da):37,473
Last modified:May 29, 2007 - v1
Checksum:i9D31DB6955D05AE7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000660 Genomic DNA. Translation: ABP51523.1.
RefSeqiWP_011901428.1. NC_009376.1.
YP_001154175.1. NC_009376.1.

Genome annotation databases

EnsemblBacteriaiABP51523; ABP51523; Pars_1976.
GeneIDi5054452.
KEGGipas:Pars_1976.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000660 Genomic DNA. Translation: ABP51523.1.
RefSeqiWP_011901428.1. NC_009376.1.
YP_001154175.1. NC_009376.1.

3D structure databases

ProteinModelPortaliA4WMA6.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABP51523; ABP51523; Pars_1976.
GeneIDi5054452.
KEGGipas:Pars_1976.

Phylogenomic databases

eggNOGiCOG1405.
HOGENOMiHOG000108633.
KOiK03124.
OMAiWRAFDHD.

Enzyme and pathway databases

BioCyciPARS340102:GHGQ-2005-MONOMER.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
HAMAPiMF_00383. TF2B_arch.
InterProiIPR013763. Cyclin-like.
IPR000812. TFIIB.
IPR023484. TFIIB_arc.
IPR023486. TFIIB_CS.
IPR013150. TFIIB_cyclin.
IPR013137. Znf_TFIIB.
[Graphical view]
PANTHERiPTHR11618. PTHR11618. 1 hit.
PfamiPF08271. TF_Zn_Ribbon. 1 hit.
PF00382. TFIIB. 2 hits.
[Graphical view]
PRINTSiPR00685. TIFACTORIIB.
SMARTiSM00385. CYCLIN. 2 hits.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
PROSITEiPS00782. TFIIB. 2 hits.
PS51134. ZF_TFIIB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 13514 / JCM 11321.

Entry informationi

Entry nameiTF2B_PYRAR
AccessioniPrimary (citable) accession number: A4WMA6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 29, 2007
Last modified: July 22, 2015
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.