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A4WMA6

- TF2B_PYRAR

UniProt

A4WMA6 - TF2B_PYRAR

Protein

Transcription initiation factor IIB

Gene

tfb

Organism
Pyrobaculum arsenaticum (strain DSM 13514 / JCM 11321)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (29 May 2007)
      Previous versions | rss
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    Functioni

    Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).UniRule annotation

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi37 – 371ZincUniRule annotation
    Metal bindingi40 – 401ZincUniRule annotation
    Metal bindingi56 – 561ZincUniRule annotation
    Metal bindingi59 – 591ZincUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri33 – 6432TFIIB-typeUniRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding transcription factor activity Source: UniProtKB-HAMAP
    2. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. DNA-templated transcription, initiation Source: UniProtKB-HAMAP

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciPARS340102:GHGQ-2005-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription initiation factor IIBUniRule annotation
    Short name:
    TFIIBUniRule annotation
    Gene namesi
    Name:tfbUniRule annotation
    Ordered Locus Names:Pars_1976
    OrganismiPyrobaculum arsenaticum (strain DSM 13514 / JCM 11321)
    Taxonomic identifieri340102 [NCBI]
    Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaePyrobaculum
    ProteomesiUP000001567: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 333333Transcription initiation factor IIBPRO_1000080115Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi340102.Pars_1976.

    Structurei

    3D structure databases

    ProteinModelPortaliA4WMA6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati149 – 232841Add
    BLAST
    Repeati243 – 324822Add
    BLAST

    Sequence similaritiesi

    Belongs to the TFIIB family.UniRule annotation
    Contains 1 TFIIB-type zinc finger.UniRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri33 – 6432TFIIB-typeUniRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG1405.
    HOGENOMiHOG000108633.
    KOiK03124.
    OMAiCDSQNIS.

    Family and domain databases

    Gene3Di1.10.472.10. 2 hits.
    HAMAPiMF_00383. TF2B_arch.
    InterProiIPR013763. Cyclin-like.
    IPR000812. TFIIB.
    IPR023484. TFIIB_arc.
    IPR023486. TFIIB_CS.
    IPR013150. TFIIB_cyclin.
    IPR013137. Znf_TFIIB.
    [Graphical view]
    PANTHERiPTHR11618. PTHR11618. 1 hit.
    PfamiPF08271. TF_Zn_Ribbon. 1 hit.
    PF00382. TFIIB. 2 hits.
    [Graphical view]
    PRINTSiPR00685. TIFACTORIIB.
    SMARTiSM00385. CYCLIN. 2 hits.
    [Graphical view]
    SUPFAMiSSF47954. SSF47954. 2 hits.
    PROSITEiPS00782. TFIIB. 2 hits.
    PS51134. ZF_TFIIB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A4WMA6-1 [UniParc]FASTAAdd to Basket

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    MSSTSLPSSG KPLKLRINRD SEGYLSLVTE SGEIYRCPIC GNDRFVYNYE    50
    RGEVVCIVCG AVVQEQLLDL GPEWRAFTSE EKGQRARTGA PLTRLISEAL 100
    TTVIDWRDKD VSGRELDIKR KLEVIRLRKW QTRARVQTSY ERNFIQAAQE 150
    LERLKSSMGV PRPCVEQALE IYRQALEKEL VRGRSVEAMA AAALYMACRM 200
    MRMPRPLDEL VRYTKASRRE VARCYRLLLR ELNVKVPISD PVLYISRIAE 250
    QLKLSGEVVK AAIDILQRAK KAGITAGKDP AGLAAAAVYI ASLMHGDNRT 300
    QKDFAVAAGV TEVTVRNRYK ELAKALNIKV PVK 333
    Length:333
    Mass (Da):37,473
    Last modified:May 29, 2007 - v1
    Checksum:i9D31DB6955D05AE7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000660 Genomic DNA. Translation: ABP51523.1.
    RefSeqiWP_011901428.1. NC_009376.1.
    YP_001154175.1. NC_009376.1.

    Genome annotation databases

    EnsemblBacteriaiABP51523; ABP51523; Pars_1976.
    GeneIDi5054452.
    KEGGipas:Pars_1976.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000660 Genomic DNA. Translation: ABP51523.1 .
    RefSeqi WP_011901428.1. NC_009376.1.
    YP_001154175.1. NC_009376.1.

    3D structure databases

    ProteinModelPortali A4WMA6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 340102.Pars_1976.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABP51523 ; ABP51523 ; Pars_1976 .
    GeneIDi 5054452.
    KEGGi pas:Pars_1976.

    Phylogenomic databases

    eggNOGi COG1405.
    HOGENOMi HOG000108633.
    KOi K03124.
    OMAi CDSQNIS.

    Enzyme and pathway databases

    BioCyci PARS340102:GHGQ-2005-MONOMER.

    Family and domain databases

    Gene3Di 1.10.472.10. 2 hits.
    HAMAPi MF_00383. TF2B_arch.
    InterProi IPR013763. Cyclin-like.
    IPR000812. TFIIB.
    IPR023484. TFIIB_arc.
    IPR023486. TFIIB_CS.
    IPR013150. TFIIB_cyclin.
    IPR013137. Znf_TFIIB.
    [Graphical view ]
    PANTHERi PTHR11618. PTHR11618. 1 hit.
    Pfami PF08271. TF_Zn_Ribbon. 1 hit.
    PF00382. TFIIB. 2 hits.
    [Graphical view ]
    PRINTSi PR00685. TIFACTORIIB.
    SMARTi SM00385. CYCLIN. 2 hits.
    [Graphical view ]
    SUPFAMi SSF47954. SSF47954. 2 hits.
    PROSITEi PS00782. TFIIB. 2 hits.
    PS51134. ZF_TFIIB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 13514 / JCM 11321.

    Entry informationi

    Entry nameiTF2B_PYRAR
    AccessioniPrimary (citable) accession number: A4WMA6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: May 29, 2007
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3