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Protein

Geranylgeranylglyceryl phosphate synthase

Gene

Pars_1793

Organism
Pyrobaculum arsenaticum (strain DSM 13514 / JCM 11321)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.UniRule annotation

Catalytic activityi

Geranylgeranyl diphosphate + sn-glycerol 1-phosphate = diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Pathwayi: glycerophospholipid metabolism

This protein is involved in the pathway glycerophospholipid metabolism, which is part of Membrane lipid metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway glycerophospholipid metabolism and in Membrane lipid metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi18 – 181MagnesiumUniRule annotation
Metal bindingi45 – 451MagnesiumUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciPARS340102:GHGQ-1817-MONOMER.
UniPathwayiUPA00940.

Names & Taxonomyi

Protein namesi
Recommended name:
Geranylgeranylglyceryl phosphate synthaseUniRule annotation (EC:2.5.1.41UniRule annotation)
Short name:
GGGP synthaseUniRule annotation
Short name:
GGGPSUniRule annotation
Alternative name(s):
(S)-3-O-geranylgeranylglyceryl phosphate synthaseUniRule annotation
Phosphoglycerol geranylgeranyltransferaseUniRule annotation
Gene namesi
Ordered Locus Names:Pars_1793
OrganismiPyrobaculum arsenaticum (strain DSM 13514 / JCM 11321)
Taxonomic identifieri340102 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaePyrobaculum
Proteomesi
  • UP000001567 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 239239Geranylgeranylglyceryl phosphate synthasePRO_0000304186Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliA4WLS7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni166 – 1727Glycerol-1-phosphate bindingUniRule annotation
Regioni197 – 1982Glycerol-1-phosphate bindingUniRule annotation
Regioni219 – 2202Glycerol-1-phosphate bindingUniRule annotation

Sequence similaritiesi

Belongs to the GGGP/HepGP synthase family. Group II subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000034117.
KOiK17104.
OMAiEPIPMAY.

Family and domain databases

Gene3Di3.20.20.390. 1 hit.
HAMAPiMF_00112. GGGP_HepGP_synthase. 1 hit.
InterProiIPR008205. GGGP_HepGP_synthase.
IPR010946. GGGP_synth.
[Graphical view]
PfamiPF01884. PcrB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01769. GGGP. 1 hit.
TIGR01768. GGGP-family. 1 hit.

Sequencei

Sequence statusi: Complete.

A4WLS7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLYEYLSQG IKHFTLIDPD KSVDYLRIAR YALEAGTDGI LVGGSLGITA
60 70 80 90 100
SQMEKVVKDI KSVANVPVVL FPGSLSQLTD AADGVLFLSV LNSLDPYFII
110 120 130 140 150
GAQVHGAVLI AKHYPRLEVI STAYVIVGDG GAAGFVSMSK PIPYTRPDIA
160 170 180 190 200
TAYALAAGYI GFKALYLEAG SGAPQPVPPD MVRAVRKAFP RVLIVGGGIR
210 220 230
SSEVARSIAR EGPNVIVTGT LAEESPEKLG EIVRAIKQR
Length:239
Mass (Da):25,341
Last modified:May 29, 2007 - v1
Checksum:iE1D1C6A0C21F36F3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000660 Genomic DNA. Translation: ABP51344.1.

Genome annotation databases

EnsemblBacteriaiABP51344; ABP51344; Pars_1793.
KEGGipas:Pars_1793.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000660 Genomic DNA. Translation: ABP51344.1.

3D structure databases

ProteinModelPortaliA4WLS7.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABP51344; ABP51344; Pars_1793.
KEGGipas:Pars_1793.

Phylogenomic databases

HOGENOMiHOG000034117.
KOiK17104.
OMAiEPIPMAY.

Enzyme and pathway databases

UniPathwayiUPA00940.
BioCyciPARS340102:GHGQ-1817-MONOMER.

Family and domain databases

Gene3Di3.20.20.390. 1 hit.
HAMAPiMF_00112. GGGP_HepGP_synthase. 1 hit.
InterProiIPR008205. GGGP_HepGP_synthase.
IPR010946. GGGP_synth.
[Graphical view]
PfamiPF01884. PcrB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01769. GGGP. 1 hit.
TIGR01768. GGGP-family. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGGGPS_PYRAR
AccessioniPrimary (citable) accession number: A4WLS7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: May 29, 2007
Last modified: July 6, 2016
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.