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A4WLP0 (SYR_PYRAR) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Arginine--tRNA ligase

EC=6.1.1.19
Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS
Gene names
Name:argS
Ordered Locus Names:Pars_1756
OrganismPyrobaculum arsenaticum (strain DSM 13514 / JCM 11321) [Complete proteome] [HAMAP]
Taxonomic identifier340102 [NCBI]
Taxonomic lineageArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaePyrobaculum

Protein attributes

Sequence length630 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP-Rule MF_00123

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00123.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processarginyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

arginine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 630630Arginine--tRNA ligase HAMAP-Rule MF_00123
PRO_1000018097

Regions

Motif120 – 13011"HIGH" region HAMAP-Rule MF_00123

Sequences

Sequence LengthMass (Da)Tools
A4WLP0 [UniParc].

Last modified May 29, 2007. Version 1.
Checksum: DC8A880FD4D58C43

FASTA63071,544
        10         20         30         40         50         60 
MDPLKLPKQE FADALGKISS RLGLAEVPEI EKTRRYGYFS ARFHKYKIDP TRLRDAVEEL 

        70         80         90        100        110        120 
SNAGFQYISG LSAEGLYVNA DLNAKRLGEL VFEAVAKMGK KYGFTEECQL GSFLVEHTSA 

       130        140        150        160        170        180 
NPIHPLHIGH GRNAILGDSL ARLLRFCDNR VEVHFYVDDC GVQVMYATIG YNAVRDEARE 

       190        200        210        220        230        240 
WIERAKPDLV VGHIYSATNA VAEIGRLKKE AERAQDDEHK RSLIGEIDEW VAVLKRLMES 

       250        260        270        280        290        300 
EGDLVAKVVE RLGQRDVAGE AVELNRRYEA GDPEAKRVVR EVVDLVLRGQ RETLARLGIE 

       310        320        330        340        350        360 
IDRWDYESEL AVWSGEASRI VEELQRRWPQ YVEYKGGAVV FRADKFVDDF KLWDVLDLPK 

       370        380        390        400        410        420 
FIPPVTLTRS DGTTLYVTRD VAYALWQARQ GFDKVVRVIS TEQTHEQAHV RIILYALGFE 

       430        440        450        460        470        480 
DVAKKIVHYA YEMVNLPGMK MSARRGRYIS LDEILDEAAE RSASLVKEKS PEIAGVIAEK 

       490        500        510        520        530        540 
VGVGSVRYAF LSTSPRKPIE FRWEVVLNLR QNSGTFLQYT YVRAYSILEK APDVERASVP 

       550        560        570        580        590        600 
EQMLEEEKEL LVKIAEWPSV VREAVRALRP DYVAEYLDGL ALLFNSYYEK APVLKAVEGV 

       610        620        630 
RKFRIALVNA VKTVLEAGFY ILGIPTLTKM 

« Hide

References

[1]"Complete sequence of Pyrobaculum arsenaticum DSM 13514."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N. expand/collapse author list , Cozen A.E., Fitz-Gibbon S.T., House C.H., Saltikov C., Lowe T.M., Richardson P.
Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 13514 / JCM 11321.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000660 Genomic DNA. Translation: ABP51307.1.
RefSeqYP_001153959.1. NC_009376.1.

3D structure databases

ProteinModelPortalA4WLP0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING340102.Pars_1756.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABP51307; ABP51307; Pars_1756.
GeneID5055232.
KEGGpas:Pars_1756.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0018.
HOGENOMHOG000247213.
KOK01887.
OMALCNVLAK.

Enzyme and pathway databases

BioCycPARS340102:GHGQ-1778-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
HAMAPMF_00123. Arg_tRNA_synth.
InterProIPR001278. Arg-tRNA-ligase.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERPTHR11956. PTHR11956. 1 hit.
PfamPF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 2 hits.
[Graphical view]
PRINTSPR01038. TRNASYNTHARG.
SMARTSM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMSSF47323. SSF47323. 1 hit.
TIGRFAMsTIGR00456. argS. 1 hit.
ProtoNetSearch...

Entry information

Entry nameSYR_PYRAR
AccessionPrimary (citable) accession number: A4WLP0
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 29, 2007
Last modified: May 14, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries