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Protein

Arginine--tRNA ligase

Gene

argS

Organism
Pyrobaculum arsenaticum (strain DSM 13514 / JCM 11321)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPARS340102:GHGQ-1778-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine--tRNA ligaseUniRule annotation (EC:6.1.1.19UniRule annotation)
Alternative name(s):
Arginyl-tRNA synthetaseUniRule annotation
Short name:
ArgRSUniRule annotation
Gene namesi
Name:argSUniRule annotation
Ordered Locus Names:Pars_1756
OrganismiPyrobaculum arsenaticum (strain DSM 13514 / JCM 11321)
Taxonomic identifieri340102 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaePyrobaculum
ProteomesiUP000001567 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 630630Arginine--tRNA ligasePRO_1000018097Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliA4WLP0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi120 – 13011"HIGH" regionAdd
BLAST

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0018.
HOGENOMiHOG000247213.
KOiK01887.
OMAiEQTHEQA.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
HAMAPiMF_00123. Arg_tRNA_synth.
InterProiIPR001278. Arg-tRNA-ligase.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERiPTHR11956. PTHR11956. 1 hit.
PfamiPF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 2 hits.
[Graphical view]
PRINTSiPR01038. TRNASYNTHARG.
SMARTiSM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
TIGRFAMsiTIGR00456. argS. 1 hit.

Sequencei

Sequence statusi: Complete.

A4WLP0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPLKLPKQE FADALGKISS RLGLAEVPEI EKTRRYGYFS ARFHKYKIDP
60 70 80 90 100
TRLRDAVEEL SNAGFQYISG LSAEGLYVNA DLNAKRLGEL VFEAVAKMGK
110 120 130 140 150
KYGFTEECQL GSFLVEHTSA NPIHPLHIGH GRNAILGDSL ARLLRFCDNR
160 170 180 190 200
VEVHFYVDDC GVQVMYATIG YNAVRDEARE WIERAKPDLV VGHIYSATNA
210 220 230 240 250
VAEIGRLKKE AERAQDDEHK RSLIGEIDEW VAVLKRLMES EGDLVAKVVE
260 270 280 290 300
RLGQRDVAGE AVELNRRYEA GDPEAKRVVR EVVDLVLRGQ RETLARLGIE
310 320 330 340 350
IDRWDYESEL AVWSGEASRI VEELQRRWPQ YVEYKGGAVV FRADKFVDDF
360 370 380 390 400
KLWDVLDLPK FIPPVTLTRS DGTTLYVTRD VAYALWQARQ GFDKVVRVIS
410 420 430 440 450
TEQTHEQAHV RIILYALGFE DVAKKIVHYA YEMVNLPGMK MSARRGRYIS
460 470 480 490 500
LDEILDEAAE RSASLVKEKS PEIAGVIAEK VGVGSVRYAF LSTSPRKPIE
510 520 530 540 550
FRWEVVLNLR QNSGTFLQYT YVRAYSILEK APDVERASVP EQMLEEEKEL
560 570 580 590 600
LVKIAEWPSV VREAVRALRP DYVAEYLDGL ALLFNSYYEK APVLKAVEGV
610 620 630
RKFRIALVNA VKTVLEAGFY ILGIPTLTKM
Length:630
Mass (Da):71,544
Last modified:May 29, 2007 - v1
Checksum:iDC8A880FD4D58C43
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000660 Genomic DNA. Translation: ABP51307.1.
RefSeqiWP_011901212.1. NC_009376.1.
YP_001153959.1. NC_009376.1.

Genome annotation databases

EnsemblBacteriaiABP51307; ABP51307; Pars_1756.
GeneIDi5055232.
KEGGipas:Pars_1756.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000660 Genomic DNA. Translation: ABP51307.1.
RefSeqiWP_011901212.1. NC_009376.1.
YP_001153959.1. NC_009376.1.

3D structure databases

ProteinModelPortaliA4WLP0.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABP51307; ABP51307; Pars_1756.
GeneIDi5055232.
KEGGipas:Pars_1756.

Phylogenomic databases

eggNOGiCOG0018.
HOGENOMiHOG000247213.
KOiK01887.
OMAiEQTHEQA.

Enzyme and pathway databases

BioCyciPARS340102:GHGQ-1778-MONOMER.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
HAMAPiMF_00123. Arg_tRNA_synth.
InterProiIPR001278. Arg-tRNA-ligase.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERiPTHR11956. PTHR11956. 1 hit.
PfamiPF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 2 hits.
[Graphical view]
PRINTSiPR01038. TRNASYNTHARG.
SMARTiSM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
TIGRFAMsiTIGR00456. argS. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 13514 / JCM 11321.

Entry informationi

Entry nameiSYR_PYRAR
AccessioniPrimary (citable) accession number: A4WLP0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 29, 2007
Last modified: July 22, 2015
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.