Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Tryptophan--tRNA ligase

Gene

trpS

Organism
Pyrobaculum arsenaticum (strain DSM 13514 / JCM 11321)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligaseUniRule annotation (EC:6.1.1.2UniRule annotation)
Alternative name(s):
Tryptophanyl-tRNA synthetaseUniRule annotation
Short name:
TrpRSUniRule annotation
Gene namesi
Name:trpSUniRule annotation
Ordered Locus Names:Pars_1612
OrganismiPyrobaculum arsenaticum (strain DSM 13514 / JCM 11321)
Taxonomic identifieri340102 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaePyrobaculum
Proteomesi
  • UP000001567 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000189961 – 374Tryptophan--tRNA ligaseAdd BLAST374

Proteomic databases

PRIDEiA4WL99

Structurei

3D structure databases

ProteinModelPortaliA4WL99
SMRiA4WL99
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi81 – 89"HIGH" region9
Motifi258 – 262"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000224742
KOiK01867
OMAiADILHPQ
OrthoDBiPOG093Z034D

Family and domain databases

CDDicd00806 TrpRS_core, 1 hit
Gene3Di3.40.50.620, 1 hit
HAMAPiMF_00140_A Trp_tRNA_synth_A, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002305 aa-tRNA-synth_Ic
IPR014729 Rossmann-like_a/b/a_fold
IPR002306 Trp-tRNA-ligase
IPR020653 Tryptophan-tRNA-ligase_arc
PfamiView protein in Pfam
PF00579 tRNA-synt_1b, 1 hit
PRINTSiPR01039 TRNASYNTHTRP
TIGRFAMsiTIGR00233 trpS, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

A4WL99-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGEDFVVTPW EVRGKVDYEK LLRQFGAKPL TAEEVALLEK YAGDVHPLIK
60 70 80 90 100
RGFFYAHRDF DFILKWHGEG RPWALYTGRG PSGPVHIGHM VPWILLKWFS
110 120 130 140 150
DKFGVEVYFQ MTDDEKFFDD PEMKLEEATG WAYENALDVI ALGFGPDKLH
160 170 180 190 200
LIVDTKDIAP LYPIAVRVAK KLTWNTVKAT FGFTDSSNIG LIFYPSLQIA
210 220 230 240 250
VAFLPTELKK EPTPVLIPCA IDQDPYFRLA RDIADSLSYP KPTTLYSKFI
260 270 280 290 300
MALTGESKMS ASNPDSAIYT MDDDKTVKHK ILNAFTGGRP TAEEQRKYGG
310 320 330 340 350
NPDICPVFHY HMLFDPDDAS VEKIRQDCKS GALLCGECKL KLHEKISKFL
360 370
KEHRERREKA RGKVDEYRLS VKLK
Length:374
Mass (Da):42,636
Last modified:May 29, 2007 - v1
Checksum:i6720CBFF77A8635C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000660 Genomic DNA Translation: ABP51166.1

Genome annotation databases

EnsemblBacteriaiABP51166; ABP51166; Pars_1612
KEGGipas:Pars_1612

Similar proteinsi

Entry informationi

Entry nameiSYW_PYRAR
AccessioniPrimary (citable) accession number: A4WL99
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 29, 2007
Last modified: May 23, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health