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A4WL99

- SYW_PYRAR

UniProt

A4WL99 - SYW_PYRAR

Protein

Tryptophan--tRNA ligase

Gene

trpS

Organism
Pyrobaculum arsenaticum (strain DSM 13514 / JCM 11321)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (29 May 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. tryptophan-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. tryptophanyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciPARS340102:GHGQ-1630-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tryptophan--tRNA ligaseUniRule annotation (EC:6.1.1.2UniRule annotation)
    Alternative name(s):
    Tryptophanyl-tRNA synthetaseUniRule annotation
    Short name:
    TrpRSUniRule annotation
    Gene namesi
    Name:trpSUniRule annotation
    Ordered Locus Names:Pars_1612
    OrganismiPyrobaculum arsenaticum (strain DSM 13514 / JCM 11321)
    Taxonomic identifieri340102 [NCBI]
    Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaePyrobaculum
    ProteomesiUP000001567: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 374374Tryptophan--tRNA ligasePRO_1000018996Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi340102.Pars_1612.

    Structurei

    3D structure databases

    ProteinModelPortaliA4WL99.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi81 – 899"HIGH" region
    Motifi258 – 2625"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0180.
    HOGENOMiHOG000224742.
    KOiK01867.
    OMAiKTFIFNN.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    HAMAPiMF_00140_A. Trp_tRNA_synth_A.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002305. aa-tRNA-synth_Ic.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR002306. Trp-tRNA-ligase.
    IPR020653. Tryptophan-tRNA-ligase_arc.
    [Graphical view]
    PANTHERiPTHR10055. PTHR10055. 1 hit.
    PfamiPF00579. tRNA-synt_1b. 1 hit.
    [Graphical view]
    PRINTSiPR01039. TRNASYNTHTRP.
    TIGRFAMsiTIGR00233. trpS. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A4WL99-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGEDFVVTPW EVRGKVDYEK LLRQFGAKPL TAEEVALLEK YAGDVHPLIK    50
    RGFFYAHRDF DFILKWHGEG RPWALYTGRG PSGPVHIGHM VPWILLKWFS 100
    DKFGVEVYFQ MTDDEKFFDD PEMKLEEATG WAYENALDVI ALGFGPDKLH 150
    LIVDTKDIAP LYPIAVRVAK KLTWNTVKAT FGFTDSSNIG LIFYPSLQIA 200
    VAFLPTELKK EPTPVLIPCA IDQDPYFRLA RDIADSLSYP KPTTLYSKFI 250
    MALTGESKMS ASNPDSAIYT MDDDKTVKHK ILNAFTGGRP TAEEQRKYGG 300
    NPDICPVFHY HMLFDPDDAS VEKIRQDCKS GALLCGECKL KLHEKISKFL 350
    KEHRERREKA RGKVDEYRLS VKLK 374
    Length:374
    Mass (Da):42,636
    Last modified:May 29, 2007 - v1
    Checksum:i6720CBFF77A8635C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000660 Genomic DNA. Translation: ABP51166.1.
    RefSeqiWP_011901073.1. NC_009376.1.
    YP_001153818.1. NC_009376.1.

    Genome annotation databases

    EnsemblBacteriaiABP51166; ABP51166; Pars_1612.
    GeneIDi5056275.
    KEGGipas:Pars_1612.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000660 Genomic DNA. Translation: ABP51166.1 .
    RefSeqi WP_011901073.1. NC_009376.1.
    YP_001153818.1. NC_009376.1.

    3D structure databases

    ProteinModelPortali A4WL99.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 340102.Pars_1612.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABP51166 ; ABP51166 ; Pars_1612 .
    GeneIDi 5056275.
    KEGGi pas:Pars_1612.

    Phylogenomic databases

    eggNOGi COG0180.
    HOGENOMi HOG000224742.
    KOi K01867.
    OMAi KTFIFNN.

    Enzyme and pathway databases

    BioCyci PARS340102:GHGQ-1630-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    HAMAPi MF_00140_A. Trp_tRNA_synth_A.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002305. aa-tRNA-synth_Ic.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR002306. Trp-tRNA-ligase.
    IPR020653. Tryptophan-tRNA-ligase_arc.
    [Graphical view ]
    PANTHERi PTHR10055. PTHR10055. 1 hit.
    Pfami PF00579. tRNA-synt_1b. 1 hit.
    [Graphical view ]
    PRINTSi PR01039. TRNASYNTHTRP.
    TIGRFAMsi TIGR00233. trpS. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 13514 / JCM 11321.

    Entry informationi

    Entry nameiSYW_PYRAR
    AccessioniPrimary (citable) accession number: A4WL99
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: May 29, 2007
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3