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Protein

Thymidine kinase

Gene

tdk

Organism
Pyrobaculum arsenaticum (strain DSM 13514 / JCM 11321)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei84Proton acceptorUniRule annotation1
Metal bindingi139ZincUniRule annotation1
Metal bindingi142ZincUniRule annotation1
Metal bindingi177ZincUniRule annotation1
Metal bindingi180ZincUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi7 – 14ATPUniRule annotation8
Nucleotide bindingi83 – 86ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationImported, Transferase
Biological processDNA synthesisUniRule annotation
LigandATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
Ordered Locus Names:Pars_1427Imported
OrganismiPyrobaculum arsenaticum (strain DSM 13514 / JCM 11321)Imported
Taxonomic identifieri340102 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaePyrobaculum
Proteomesi
  • UP000001567 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA4WKR8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000076390
KOiK00857
OMAiKEQFGWI
OrthoDBiPOG093Z0AT6

Family and domain databases

HAMAPiMF_00124 Thymidine_kinase, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR001267 Thymidine_kinase
IPR020633 Thymidine_kinase_CS
PANTHERiPTHR11441 PTHR11441, 1 hit
PfamiView protein in Pfam
PF00265 TK, 1 hit
PIRSFiPIRSF035805 TK_cell, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00603 TK_CELLULAR_TYPE, 1 hit

Sequencei

Sequence statusi: Complete.

A4WKR8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLIVIVGPMF AGKTTELIRR VERYVIAGKR AIVFKPSIDA RYDSSKVAAH
60 70 80 90 100
NGLKFGAYVV PPDEAGVEAI GKLGLDYDVV AVDEIQFFPP SLADVLNGLA
110 120 130 140 150
DGRVVIAAGL NLDFRGEPFE TTMRTMAFAD RVISLTAVCK VCGRPATRTQ
160 170 180
RLINGLPAPR DSPRILVGGG DSYEARCRRH YVRPA
Length:185
Mass (Da):20,089
Last modified:May 29, 2007 - v1
Checksum:i16D4EE89694AC7C1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000660 Genomic DNA Translation: ABP50985.1

Genome annotation databases

EnsemblBacteriaiABP50985; ABP50985; Pars_1427
KEGGipas:Pars_1427

Similar proteinsi

Entry informationi

Entry nameiA4WKR8_PYRAR
AccessioniPrimary (citable) accession number: A4WKR8
Entry historyiIntegrated into UniProtKB/TrEMBL: May 29, 2007
Last sequence update: May 29, 2007
Last modified: May 23, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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