A4WJI4 (ARLY_PYRAR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Argininosuccinate lyase
Short name=ASAL
EC=4.3.2.1

Alternative name(s):
Arginosuccinase

Gene names

Name:	argH
Ordered Locus Names:	Pars_0971

Organism

Pyrobaculum arsenaticum (strain DSM 13514 / JCM 11321) [Complete proteome] [HAMAP]

Taxonomic identifier

340102 [NCBI]

Taxonomic lineage

Archaea › Crenarchaeota › Thermoprotei › Thermoproteales › Thermoproteaceae › Pyrobaculum

Protein attributes

Sequence length	429 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	2-(N(omega)-L-arginino)succinate = fumarate + L-arginine. HAMAP MF_00006
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. HAMAP MF_00006
Subcellular location	Cytoplasm By similarity HAMAP MF_00006.
Sequence similarities	Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process via ornithine Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	argininosuccinate lyase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 429	429	Argininosuccinate lyase HAMAP MF_00006		PRO_1000089104

Sequences

	Sequence		Length	Mass (Da)
	A4WJI4 [UniParc]. Last modified May 29, 2007. Version 1. Checksum: 6605B6CB087660CF	FASTA	429	47,299
	10 20 30 40 50 60 MSFYRSWIGG RGDLVQRYTS SIRDDAEIAE EVVKVMKAHV THLAEIGALR KEVADKIVAA 70 80 90 100 110 120 LEEVDPTELL RGEFEDIHEA LEKWLIDKLG EDVGGWVGLA RSRNDHVAAA IRLAALKKVG 130 140 150 160 170 180 ALREAAMRLR CALAARALEY ADCPMPSFTH FQPAQVVTFG HYLLAVDELV AEFLHVLAAA 190 200 210 220 230 240 EDLAKRSPLG AGPAGGVRTP VDRRRLAELA GFKDVVENTL YASGGRFFAL ALASAVTSFL 250 260 270 280 290 300 VELSRAVDDF IRWNNPLLGY VEAPPEHVST SSIMPHKRNL VTLEVLRARS EEAVGHYAAL 310 320 330 340 350 360 SGVVAKVGLG YSLDLQEATR HLWDILNIAI EGVEVLADFV EKIKFNCEKG RRDAELYYAT 370 380 390 400 410 420 SSDTAEERAL RGVPFRKAYF ELASEIREGK ARLLTVDEAL KRPVLGSANP EEVRKSASRR LALCRPKSF

References

[1]

"Complete sequence of Pyrobaculum arsenaticum DSM 13514." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N. , Cozen A.E., Fitz-Gibbon S.T., House C.H., Saltikov C., Lowe T.M., Richardson P. Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 13514 / JCM 11321.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000660 Genomic DNA. Translation: ABP50551.1.
RefSeq	YP_001153203.1. NC_009376.1.
3D structure databases
ProteinModelPortal	A4WJI4.
ModBase	Search...
Protein-protein interaction databases
STRING	A4WJI4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5054410.
GenomeReviews	Gene locus Pars_0971 in contig CP000660_GR.
KEGG	pas:Pars_0971.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	arNOG04975.
HOGENOM	HBG539632.
OMA	EDIHTVI.
ProtClustDB	PRK00855.
Enzyme and pathway databases
BioCyc	PARS340102:PARS_0971-MONOMER.
Family and domain databases
HAMAP	MF_00006. Arg_succ_lyase. [Tree]
InterPro	IPR009049. Argininosuccinate_lyase. IPR003031. D_crystallin. IPR000362. Fumarate_lyase. IPR008948. L-Aspartase-like. IPR022761. Lyase1_N. [Graphical view]
KO	K01755.
PANTHER	PTHR11444:SF3. argH. 1 hit.
Pfam	PF00206. Lyase_1. 1 hit. [Graphical view]
PRINTS	PR00145. ARGSUCLYASE. PR00149. FUMRATELYASE.
SUPFAM	SSF48557. L-Aspartase-like. 1 hit.
PROSITE	PS00163. FUMARATE_LYASES. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARLY_PYRAR

Accession

Primary (citable) accession number: A4WJI4

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	May 29, 2007
Last modified:	January 25, 2012
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program