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Protein

Nicotinamide-nucleotide adenylyltransferase

Gene

Pars_0405

Organism
Pyrobaculum arsenaticum (strain DSM 13514 / JCM 11321)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + nicotinamide ribonucleotide = diphosphate + NAD+.UniRule annotation

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes NAD(+) from nicotinamide D-ribonucleotide.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Nicotinamide-nucleotide adenylyltransferase (Pars_0405), Nicotinamide-nucleotide adenylyltransferase (Pars_1824)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes NAD(+) from nicotinamide D-ribonucleotide, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, Transferase
Biological processPyridine nucleotide biosynthesis
LigandATP-binding, NAD, Nucleotide-binding

Enzyme and pathway databases

BioCyciPARS340102:GHGQ-392-MONOMER
UniPathwayiUPA00253; UER00600

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinamide-nucleotide adenylyltransferaseUniRule annotation (EC:2.7.7.1UniRule annotation)
Alternative name(s):
NAD(+) diphosphorylaseUniRule annotation
NAD(+) pyrophosphorylaseUniRule annotation
NMN adenylyltransferaseUniRule annotation
Gene namesi
Ordered Locus Names:Pars_0405
OrganismiPyrobaculum arsenaticum (strain DSM 13514 / JCM 11321)
Taxonomic identifieri340102 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaePyrobaculum
Proteomesi
  • UP000001567 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000057421 – 178Nicotinamide-nucleotide adenylyltransferaseAdd BLAST178

Structurei

3D structure databases

ProteinModelPortaliA4WHY9
SMRiA4WHY9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the archaeal NMN adenylyltransferase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000108858
KOiK00952
OMAiNSVWVSH
OrthoDBiPOG093Z0BGQ

Family and domain databases

Gene3Di3.40.50.620, 1 hit
HAMAPiMF_00243 NMN_adenylyltr, 1 hit
InterProiView protein in InterPro
IPR004821 Cyt_trans-like
IPR006418 NMN_Atrans_arc
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF01467 CTP_transf_like, 1 hit
TIGRFAMsiTIGR01527 arch_NMN_Atrans, 1 hit
TIGR00125 cyt_tran_rel, 1 hit

Sequencei

Sequence statusi: Complete.

A4WHY9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVRGLFPGRF QPPHWGHIYA VKEILKEVDE VIIAMGSAQF NYLLKDPFTA
60 70 80 90 100
GERIWMLREG LREGGVDLSR VVIIPIPNVE NNLEWLGRVK SYTPPFDVIY
110 120 130 140 150
TGNPFVALLF REAGYEVRQQ PMFQRERYSS TRVRELLLRG DPSWEELVPK
160 170
SVAEIIKKLR GAERIKTAAS GEAEPHKW
Length:178
Mass (Da):20,506
Last modified:May 29, 2007 - v1
Checksum:iC7D5DBD55F0392C3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000660 Genomic DNA Translation: ABP50006.1

Genome annotation databases

EnsemblBacteriaiABP50006; ABP50006; Pars_0405
KEGGipas:Pars_0405

Similar proteinsi

Entry informationi

Entry nameiNADM_PYRAR
AccessioniPrimary (citable) accession number: A4WHY9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 29, 2007
Last modified: June 20, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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