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A4WHK6

- SYL_PYRAR

UniProt

A4WHK6 - SYL_PYRAR

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Protein
Leucine--tRNA ligase
Gene
leuS, Pars_0260
Organism
Pyrobaculum arsenaticum (strain DSM 13514 / JCM 11321)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei641 – 6411ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPARS340102:GHGQ-262-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:Pars_0260
OrganismiPyrobaculum arsenaticum (strain DSM 13514 / JCM 11321)
Taxonomic identifieri340102 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaePyrobaculum
ProteomesiUP000001567: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 945945Leucine--tRNA ligaseUniRule annotation
PRO_1000009403Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi340102.Pars_0260.

Structurei

3D structure databases

ProteinModelPortaliA4WHK6.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi43 – 5311"HIGH" regionUniRule annotation
Add
BLAST
Motifi638 – 6425"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000216620.
KOiK01869.
OMAiIDKWLLH.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_A. Leu_tRNA_synth_A.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR020791. Leu-tRNA-lgase_arc.
IPR004493. Leu-tRNA-synth_Ia_arc/euk.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 2 hits.
TIGRFAMsiTIGR00395. leuS_arch. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4WHK6-1 [UniParc]FASTAAdd to Basket

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MSELARFFIE LGEKWQKRWA EARVYEPAPT LGVPKFFITA AYPYPNGAIH    50
IGHGRTYLIA DVLARFHRHL GRAVLFPMAF HYTGTPILTI AEAIAAGDET 100
VVEEYMAIYG VPEEEMRKMG DPLYLARYFH EQSKRAMQKF GLSIDWTREF 150
TTIDPEYQRF IQWQFEKLRK KGLIVRGRHP VGWCPRHSMP VGAHDTKDDK 200
EPDIGEWTLI YFADRDGLIF PAATLRPETV LGVTNMWINP EGEYVVAEYD 250
GRKMVLSRDA AYRLSFQGSV KVLREAKGRE FVGREVQNPV TGEWVPIYGA 300
KFVDPKVGTG VVMSVPAHAP YDYAALRDIG AIRLIPLIKV EGYGEYPAKD 350
VVERMEIKSQ TDPALEEATK EVYSAEYARG VMREDVVELV GRHLPEPARS 400
MVMAVFKMYF AGRPVREARE FISKWLAEAG LGGVMYDIMN KPVYCRCGTE 450
IVVKVLEDQW FINYGEPRWK ELAKKLVEEM TIVPPEAKAQ FFATIDWLDK 500
RACARTRGLG TPLPWSHGWV IESLSDSTIY MAYYAVIKGI RRHNLRPEQL 550
TEEFWDYVFL GVGTPEEVSA KTGIPAEALR AIREEFEFWY PLDSRNSGKD 600
LIPNHLTFFI FNHVAIFPRE KWPRQIVANG WVLREGEKMS KSKRNVLPLD 650
KAVEMYGPDP LRATLAISAE VEQDLDFRHA EAVRNAQQLM SIYTLAQRLA 700
QSAEDREPTW LDRWLLSEVA LALERVRDAY EKVRVRQAAV ELLYNIKNIF 750
DSYMTAVERP SRLAVEVAKA WAVALEPIAP HLAEEVWSLL GGEGFVTSAK 800
WPQLKPDPAA LLARRYVDMV VEDVKKIPAY GEGVRRVVLY INPNFTWVKA 850
ALNNDVKSAI AAGTPPQLAK RLVELVRTLG DEVRSLIAAV ENFDEREALL 900
SYKNYVEKAL GAPVEVYTAE DPAAPDLGGK KKAALPLKPG IFIER 945
Length:945
Mass (Da):107,394
Last modified:May 29, 2007 - v1
Checksum:iFBF96F309DE85956
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000660 Genomic DNA. Translation: ABP49873.1.
RefSeqiYP_001152525.1. NC_009376.1.

Genome annotation databases

EnsemblBacteriaiABP49873; ABP49873; Pars_0260.
GeneIDi5054166.
KEGGipas:Pars_0260.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000660 Genomic DNA. Translation: ABP49873.1 .
RefSeqi YP_001152525.1. NC_009376.1.

3D structure databases

ProteinModelPortali A4WHK6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 340102.Pars_0260.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABP49873 ; ABP49873 ; Pars_0260 .
GeneIDi 5054166.
KEGGi pas:Pars_0260.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000216620.
KOi K01869.
OMAi IDKWLLH.

Enzyme and pathway databases

BioCyci PARS340102:GHGQ-262-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_A. Leu_tRNA_synth_A.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR020791. Leu-tRNA-lgase_arc.
IPR004493. Leu-tRNA-synth_Ia_arc/euk.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 2 hits.
TIGRFAMsi TIGR00395. leuS_arch. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 13514 / JCM 11321.

Entry informationi

Entry nameiSYL_PYRAR
AccessioniPrimary (citable) accession number: A4WHK6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 29, 2007
Last modified: May 14, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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