Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Pyrobaculum arsenaticum (strain DSM 13514 / JCM 11321)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei641ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Pars_0260
OrganismiPyrobaculum arsenaticum (strain DSM 13514 / JCM 11321)
Taxonomic identifieri340102 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaePyrobaculum
Proteomesi
  • UP000001567 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000094031 – 945Leucine--tRNA ligaseAdd BLAST945

Structurei

3D structure databases

ProteinModelPortaliA4WHK6
SMRiA4WHK6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi43 – 53"HIGH" regionAdd BLAST11
Motifi638 – 642"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000216620
KOiK01869
OMAiHVTGTPI
OrthoDBiPOG093Z006D

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_A Leu_tRNA_synth_A, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR020791 Leu-tRNA-lgase_arc
IPR004493 Leu-tRNA-synth_Ia_arc/euk
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR11946:SF51 PTHR11946:SF51, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 1 hit
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 2 hits
TIGRFAMsiTIGR00395 leuS_arch, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

A4WHK6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSELARFFIE LGEKWQKRWA EARVYEPAPT LGVPKFFITA AYPYPNGAIH
60 70 80 90 100
IGHGRTYLIA DVLARFHRHL GRAVLFPMAF HYTGTPILTI AEAIAAGDET
110 120 130 140 150
VVEEYMAIYG VPEEEMRKMG DPLYLARYFH EQSKRAMQKF GLSIDWTREF
160 170 180 190 200
TTIDPEYQRF IQWQFEKLRK KGLIVRGRHP VGWCPRHSMP VGAHDTKDDK
210 220 230 240 250
EPDIGEWTLI YFADRDGLIF PAATLRPETV LGVTNMWINP EGEYVVAEYD
260 270 280 290 300
GRKMVLSRDA AYRLSFQGSV KVLREAKGRE FVGREVQNPV TGEWVPIYGA
310 320 330 340 350
KFVDPKVGTG VVMSVPAHAP YDYAALRDIG AIRLIPLIKV EGYGEYPAKD
360 370 380 390 400
VVERMEIKSQ TDPALEEATK EVYSAEYARG VMREDVVELV GRHLPEPARS
410 420 430 440 450
MVMAVFKMYF AGRPVREARE FISKWLAEAG LGGVMYDIMN KPVYCRCGTE
460 470 480 490 500
IVVKVLEDQW FINYGEPRWK ELAKKLVEEM TIVPPEAKAQ FFATIDWLDK
510 520 530 540 550
RACARTRGLG TPLPWSHGWV IESLSDSTIY MAYYAVIKGI RRHNLRPEQL
560 570 580 590 600
TEEFWDYVFL GVGTPEEVSA KTGIPAEALR AIREEFEFWY PLDSRNSGKD
610 620 630 640 650
LIPNHLTFFI FNHVAIFPRE KWPRQIVANG WVLREGEKMS KSKRNVLPLD
660 670 680 690 700
KAVEMYGPDP LRATLAISAE VEQDLDFRHA EAVRNAQQLM SIYTLAQRLA
710 720 730 740 750
QSAEDREPTW LDRWLLSEVA LALERVRDAY EKVRVRQAAV ELLYNIKNIF
760 770 780 790 800
DSYMTAVERP SRLAVEVAKA WAVALEPIAP HLAEEVWSLL GGEGFVTSAK
810 820 830 840 850
WPQLKPDPAA LLARRYVDMV VEDVKKIPAY GEGVRRVVLY INPNFTWVKA
860 870 880 890 900
ALNNDVKSAI AAGTPPQLAK RLVELVRTLG DEVRSLIAAV ENFDEREALL
910 920 930 940
SYKNYVEKAL GAPVEVYTAE DPAAPDLGGK KKAALPLKPG IFIER
Length:945
Mass (Da):107,394
Last modified:May 29, 2007 - v1
Checksum:iFBF96F309DE85956
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000660 Genomic DNA Translation: ABP49873.1

Genome annotation databases

EnsemblBacteriaiABP49873; ABP49873; Pars_0260
KEGGipas:Pars_0260

Similar proteinsi

Entry informationi

Entry nameiSYL_PYRAR
AccessioniPrimary (citable) accession number: A4WHK6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 29, 2007
Last modified: May 23, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health