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A4WH24 (DNLI_PYRAR) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
DNA ligase

EC=6.5.1.1
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]
Gene names
Name:lig
Ordered Locus Names:Pars_0076
OrganismPyrobaculum arsenaticum (strain DSM 13514 / JCM 11321) [Complete proteome] [HAMAP]
Taxonomic identifier340102 [NCBI]
Taxonomic lineageArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaePyrobaculum

Protein attributes

Sequence length584 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity. HAMAP-Rule MF_00407

Catalytic activity

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m). HAMAP-Rule MF_00407

Cofactor

Divalent metal cations By similarity. HAMAP-Rule MF_00407

Sequence similarities

Belongs to the ATP-dependent DNA ligase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 584584DNA ligase HAMAP-Rule MF_00407
PRO_1000049875

Sites

Active site2511N6-AMP-lysine intermediate By similarity
Binding site2491ATP By similarity
Binding site2561ATP By similarity
Binding site2711ATP By similarity
Binding site3011ATP By similarity
Binding site3411ATP By similarity
Binding site4161ATP By similarity
Binding site4221ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
A4WH24 [UniParc].

Last modified May 29, 2007. Version 1.
Checksum: D65376C5A129E101

FASTA58464,746
        10         20         30         40         50         60 
MQFGELVKAL AAVESTTQRS VMVKLLASLF KKALPEEIDK VIYLILGDLR PPWEGLELGV 

        70         80         90        100        110        120 
GEKLCLRALA KATGTSQAEL ESMYKKTGDI GEAARRALAS SKRPGLLAFG SQKPLEVSEV 

       130        140        150        160        170        180 
YDALIKVARA TGEGAQDMKI ALLSSLFARS SPEEGKYIAR FVVGKLRLGV ADMTIIEALA 

       190        200        210        220        230        240 
DAYGVRKEDL ERAYHVYPDL GHLAKLVASG KPLDEVKVTP GVPVLPMLAQ RLSSSSEILA 

       250        260        270        280        290        300 
KLGGAAICEY KYDGERAQIH ISQSGVRIFS RRLEDITHAY PDVVKAVREA VSAREAILEG 

       310        320        330        340        350        360 
EIVAVDPDTG EMLPFQELMH RKRKHEVAAA MEMYPTVLYL FDIVYVDGED LTNEPLIYRR 

       370        380        390        400        410        420 
VKLSEIVHES DKVQIAKWQM FDDPDTVDVF FHEAVSVGTE GLICKSPTSE YEMGARGWNW 

       430        440        450        460        470        480 
IKYKRDYKSE MIDTVDLVVV GAFYGRGKRA GLYGAFLLAA YDPSSDMFYT VCKVGSGFTD 

       490        500        510        520        530        540 
ADLKKMYEIL QPLKIPHRHP RVSSKMEADV WFVPQVVIEV IGAEITLSPL HTCCLGAVRP 

       550        560        570        580 
GVGLAVRFPR FTGRYRTDKG PEQATTVAEM LELYKRQKKV AQPE 

« Hide

References

[1]"Complete sequence of Pyrobaculum arsenaticum DSM 13514."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N. expand/collapse author list , Cozen A.E., Fitz-Gibbon S.T., House C.H., Saltikov C., Lowe T.M., Richardson P.
Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 13514 / JCM 11321.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000660 Genomic DNA. Translation: ABP49691.1.
RefSeqYP_001152343.1. NC_009376.1.

3D structure databases

ProteinModelPortalA4WH24.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING340102.Pars_0076.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABP49691; ABP49691; Pars_0076.
GeneID5054375.
KEGGpas:Pars_0076.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1793.
HOGENOMHOG000036008.
KOK10747.
OMAYIARFVV.
ProtClustDBPRK01109.

Enzyme and pathway databases

BioCycPARS340102:GHGQ-76-MONOMER.

Family and domain databases

Gene3D1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPMF_00407. DNA_ligase.
InterProIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsTIGR00574. dnl1. 1 hit.
PROSITEPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDNLI_PYRAR
AccessionPrimary (citable) accession number: A4WH24
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 29, 2007
Last modified: February 19, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families