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A4WG54 (ARGE_ENT38) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Acetylornithine deacetylase

Short name=AO
Short name=Acetylornithinase
EC=3.5.1.16
Alternative name(s):
N-acetylornithinase
Short name=NAO
Gene names
Name:argE
Ordered Locus Names:Ent638_4029
OrganismEnterobacter sp. (strain 638) [Complete proteome] [HAMAP]
Taxonomic identifier399742 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEnterobacter

Protein attributes

Sequence length383 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

N(2)-acetyl-L-ornithine + H2O = acetate + L-ornithine. HAMAP-Rule MF_01108

Cofactor

Binds 2 zinc or cobalt ions per subunit By similarity.

Glutathione By similarity.

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; L-ornithine from N(2)-acetyl-L-ornithine (linear): step 1/1. HAMAP-Rule MF_01108

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the peptidase M20A family. ArgE subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 383383Acetylornithine deacetylase HAMAP-Rule MF_01108
PRO_1000065057

Sites

Active site821 By similarity
Active site1441 By similarity
Metal binding801Cobalt or zinc 1 By similarity
Metal binding1121Cobalt or zinc 1 By similarity
Metal binding1121Cobalt or zinc 2 By similarity
Metal binding1451Cobalt or zinc 2 By similarity
Metal binding1691Cobalt or zinc 1 By similarity
Metal binding3551Cobalt or zinc 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
A4WG54 [UniParc].

Last modified May 29, 2007. Version 1.
Checksum: 87663F3ED5F2BBE6

FASTA38342,203
        10         20         30         40         50         60 
MKMNLPPFIE IYRALIATPS ISATEEALDQ SNESLINMLA GWFSDLGFKV EVQPVPGTRH 

        70         80         90        100        110        120 
KFNLLASAGQ GAGGLLLAGH TDTVPFDDGR WTRDPFTLTE HDGKLYGLGT ADMKGFFAFI 

       130        140        150        160        170        180 
LDALRDVDVK TLKKPLYILA TADEETSMAG ARYFSENTAI RPDCAIIGEP TSLQPIRAHK 

       190        200        210        220        230        240 
GHISTAVRVL GQSGHSSDPA RGVNAIELMH DAIGRIMVLR DSLKERFHHD SFTVPYPTLN 

       250        260        270        280        290        300 
LGSLHGGDAS NRICACCELH MDIRPLPGMT LDDLNGLLSE ALAPVSERWP GRLTIFDLHP 

       310        320        330        340        350        360 
PIPGYECPPD HQLVQVVEKL LGEKTDVVNY CTEAPFIQTL CPTLVLGPGS INQAHQPDEY 

       370        380 
LETRFIKPTR ELITQVVHHF CWH 

« Hide

References

[1]"Complete sequence of chromosome of Enterobacter sp. 638."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Detter J.C., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Kim E., Taghavi S., Newman L., Vangronsveld J., van der Lelie D., Richardson P.
Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 638.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000653 Genomic DNA. Translation: ABP62684.1.
RefSeqYP_001178735.1. NC_009436.1.

3D structure databases

ProteinModelPortalA4WG54.
ModBaseSearch...

Protein-protein interaction databases

STRING399742.Ent638_4029.

Protein family/group databases

MEROPSM20.974.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABP62684; ABP62684; Ent638_4029.
GeneID5110783.
KEGGent:Ent638_4029.
PATRIC20417843. VBIEntSp101211_4194.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0624.
HOGENOMHOG000243769.
KOK01438.
OMARICKSCE.
ProtClustDBPRK05111.

Enzyme and pathway databases

BioCycESP399742:GJ0E-4133-MONOMER.
UniPathwayUPA00068; UER00110.

Family and domain databases

HAMAPMF_01108. ArgE.
InterProIPR010169. AcOrn-deacetyl.
IPR001261. ArgE/DapE_CS.
IPR002933. Peptidase_M20.
IPR011650. Peptidase_M20_dimer.
[Graphical view]
PfamPF07687. M20_dimer. 1 hit.
PF01546. Peptidase_M20. 1 hit.
[Graphical view]
SUPFAMSSF55031. Peptidase_M20_dimer. 1 hit.
TIGRFAMsTIGR01892. AcOrn-deacetyl. 1 hit.
PROSITEPS00758. ARGE_DAPE_CPG2_1. 1 hit.
PS00759. ARGE_DAPE_CPG2_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameARGE_ENT38
AccessionPrimary (citable) accession number: A4WG54
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 29, 2007
Last modified: May 1, 2013
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Peptidase families

Classification of peptidase families and list of entries

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families