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Protein

Argininosuccinate lyase

Gene

argH

Organism
Enterobacter sp. (strain 638)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

2-(N(omega)-L-arginino)succinate = fumarate + L-arginine.UniRule annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Ornithine carbamoyltransferase (argI), Ornithine carbamoyltransferase (argI)
  2. Argininosuccinate synthase (argG)
  3. Argininosuccinate lyase (argH)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processAmino-acid biosynthesis, Arginine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00068; UER00114.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate lyaseUniRule annotation (EC:4.3.2.1UniRule annotation)
Short name:
ASALUniRule annotation
Alternative name(s):
ArginosuccinaseUniRule annotation
Gene namesi
Name:argHUniRule annotation
Ordered Locus Names:Ent638_4026
OrganismiEnterobacter sp. (strain 638)
Taxonomic identifieri399742 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEnterobacter
Proteomesi
  • UP000000230 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000570501 – 457Argininosuccinate lyaseAdd BLAST457

Proteomic databases

PRIDEiA4WG51.

Interactioni

Protein-protein interaction databases

STRINGi399742.Ent638_4026.

Structurei

3D structure databases

ProteinModelPortaliA4WG51.
SMRiA4WG51.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CH7. Bacteria.
COG0165. LUCA.
HOGENOMiHOG000242744.
KOiK01755.
OMAiSIMPHKK.

Family and domain databases

CDDicd01359. Argininosuccinate_lyase. 1 hit.
Gene3Di1.10.275.10. 1 hit.
HAMAPiMF_00006. Arg_succ_lyase. 1 hit.
InterProiView protein in InterPro
IPR029419. Arg_succ_lyase_C.
IPR009049. Argininosuccinate_lyase.
IPR024083. Fumarase/histidase_N.
IPR020557. Fumarate_lyase_CS.
IPR000362. Fumarate_lyase_fam.
IPR022761. Fumarate_lyase_N.
IPR008948. L-Aspartase-like.
PANTHERiPTHR43814. PTHR43814. 1 hit.
PfamiView protein in Pfam
PF14698. ASL_C2. 1 hit.
PF00206. Lyase_1. 1 hit.
PRINTSiPR00149. FUMRATELYASE.
SUPFAMiSSF48557. SSF48557. 1 hit.
TIGRFAMsiTIGR00838. argH. 1 hit.
PROSITEiView protein in PROSITE
PS00163. FUMARATE_LYASES. 1 hit.

Sequencei

Sequence statusi: Complete.

A4WG51-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALWGGRFTQ AADQRFKQFN DSLRFDYRLA EQDIVGSVAW SKALVTVGVL
60 70 80 90 100
SADEQVQLEE ALNNLLEEVR LNPQQILESD AEDIHSWVEG KLIDKVGQLG
110 120 130 140 150
KKLHTGRSRN DQVATDLKLW CKDTIVELLS ANRQLQNALV ETAQNNQDAV
160 170 180 190 200
MPGYTHLQRA QPVTFAHWSL AYVEMLARDE SRLQDTLKRL DVSPLGSGAL
210 220 230 240 250
AGTAYEIDRE QLAGWLGFAS ATRNSLDSVS DRDHVLELLS NASIGMVHLS
260 270 280 290 300
RFAEDLIFFN SGEAGFVELS DRVTSGSSLM PQKKNPDALE LIRGKCGRVQ
310 320 330 340 350
GALTGMMMTL KGLPLAYNKD MQEDKEGLFD ALDTWLDCLH MGALVLDGIQ
360 370 380 390 400
VKRPRCQEAA QQGYANSTEL ADYLVAKGVP FREAHHIVGE AVVEAIRQGK
410 420 430 440 450
PLEDLTLADL QKFSAVIGDD VYPILSLQSC LDKRAAKGGV SPKQVAQAIA

DAKSRLV
Length:457
Mass (Da):50,302
Last modified:May 29, 2007 - v1
Checksum:iFF9A617F8CA468FD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000653 Genomic DNA. Translation: ABP62681.1.
RefSeqiWP_015960985.1. NC_009436.1.

Genome annotation databases

EnsemblBacteriaiABP62681; ABP62681; Ent638_4026.
GeneIDi32441743.
KEGGient:Ent638_4026.

Similar proteinsi

Entry informationi

Entry nameiARLY_ENT38
AccessioniPrimary (citable) accession number: A4WG51
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 29, 2007
Last modified: October 25, 2017
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome