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A4WG31

- GPPA_ENT38

UniProt

A4WG31 - GPPA_ENT38

Protein

Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase

Gene

gppA

Organism
Enterobacter sp. (strain 638)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (29 May 2007)
      Previous versions | rss
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    Functioni

    Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities.UniRule annotation

    Catalytic activityi

    Guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    1. guanosine pentaphosphate catabolic process Source: InterPro
    2. guanosine tetraphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciESP399742:GJ0E-4103-MONOMER.
    UniPathwayiUPA00908; UER00884.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Guanosine-5'-triphosphate,3'-diphosphate pyrophosphataseUniRule annotation (EC:3.6.1.40UniRule annotation)
    Alternative name(s):
    Guanosine pentaphosphate phosphohydrolaseUniRule annotation
    pppGpp-5'-phosphohydrolaseUniRule annotation
    Gene namesi
    Name:gppAUniRule annotation
    Ordered Locus Names:Ent638_4006
    OrganismiEnterobacter sp. (strain 638)
    Taxonomic identifieri399742 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEnterobacter
    ProteomesiUP000000230: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 495495Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatasePRO_0000318615Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi399742.Ent638_4006.

    Structurei

    3D structure databases

    ProteinModelPortaliA4WG31.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GppA/Ppx family. GppA subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0248.
    HOGENOMiHOG000258672.
    KOiK01524.
    OMAiSYVHWAL.
    OrthoDBiEOG6M6JN6.

    Family and domain databases

    HAMAPiMF_01550. GppA.
    InterProiIPR023709. Guo-5TP_3DP_PyrP.
    IPR003695. Ppx_GppA.
    [Graphical view]
    PfamiPF02541. Ppx-GppA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A4WG31-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMITGSSLYA AIDLGSNSFH MLVVREVAGS IQTLTRIKRK VRLAAGLSQD    50
    NHLSPEAMER GWQCLRLFAE RLQDIPHNQI RVVATATLRL AVNSVDFIAK 100
    AQEILGCPVQ VISGEEEARL IYQGVAHTTG GDDRRLVVDI GGASTELVTG 150
    TGAQATSLFS LSMGCVTWLE RYFTDRNLAQ ENFDEAENAA REVLRPVMDK 200
    LRYHGWKVCV GASGTVQALQ EIMMAQGMDE RITLAKLQQL KQRAIQCGRL 250
    EELEIEGLTL ERALVFPSGL AILIAIFSEL DIHCMTLAGG ALREGLVYGM 300
    LHLAVEQDIR SRTLRNVQRR FIVDTEQAQR VAQLASSFAN QLKTTWALEP 350
    LSQDLLISAC ALHEMGLSID FKQAPIHAAY LVRNLDLPGF TPAQKKLLAT 400
    LLLNQTNTVD LSSLHQQNAV PPRVAEHLCR LLRLAILFAS RRRDDLLPAI 450
    KLEAEGENLT LTLPEDWLDN HPLGAEMIEQ EYQWQSYVHW ALEVK 495
    Length:495
    Mass (Da):55,115
    Last modified:May 29, 2007 - v1
    Checksum:i4E0CD34925F89C73
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000653 Genomic DNA. Translation: ABP62661.1.
    RefSeqiWP_015960965.1. NC_009436.1.
    YP_001178712.1. NC_009436.1.

    Genome annotation databases

    EnsemblBacteriaiABP62661; ABP62661; Ent638_4006.
    GeneIDi5110471.
    KEGGient:Ent638_4006.
    PATRICi20417781. VBIEntSp101211_4170.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000653 Genomic DNA. Translation: ABP62661.1 .
    RefSeqi WP_015960965.1. NC_009436.1.
    YP_001178712.1. NC_009436.1.

    3D structure databases

    ProteinModelPortali A4WG31.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 399742.Ent638_4006.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABP62661 ; ABP62661 ; Ent638_4006 .
    GeneIDi 5110471.
    KEGGi ent:Ent638_4006.
    PATRICi 20417781. VBIEntSp101211_4170.

    Phylogenomic databases

    eggNOGi COG0248.
    HOGENOMi HOG000258672.
    KOi K01524.
    OMAi SYVHWAL.
    OrthoDBi EOG6M6JN6.

    Enzyme and pathway databases

    UniPathwayi UPA00908 ; UER00884 .
    BioCyci ESP399742:GJ0E-4103-MONOMER.

    Family and domain databases

    HAMAPi MF_01550. GppA.
    InterProi IPR023709. Guo-5TP_3DP_PyrP.
    IPR003695. Ppx_GppA.
    [Graphical view ]
    Pfami PF02541. Ppx-GppA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the plant growth promoting endophytic bacterium Enterobacter sp. 638."
      Taghavi S., van der Lelie D., Hoffman A., Zhang Y.B., Walla M.D., Vangronsveld J., Newman L., Monchy S.
      PLoS Genet. 6:E1000943-E1000943(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 638.

    Entry informationi

    Entry nameiGPPA_ENT38
    AccessioniPrimary (citable) accession number: A4WG31
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: May 29, 2007
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3