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A4WG31 (GPPA_ENT38) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase

EC=3.6.1.40
Alternative name(s):
Guanosine pentaphosphate phosphohydrolase
pppGpp-5'-phosphohydrolase
Gene names
Name:gppA
Ordered Locus Names:Ent638_4006
OrganismEnterobacter sp. (strain 638) [Complete proteome] [HAMAP]
Taxonomic identifier399742 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEnterobacter

Protein attributes

Sequence length495 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities By similarity. HAMAP-Rule MF_01550

Catalytic activity

Guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate. HAMAP-Rule MF_01550

Pathway

Purine metabolism; ppGpp biosynthesis; ppGpp from GTP: step 1/2. HAMAP-Rule MF_01550

Sequence similarities

Belongs to the GppA/Ppx family. GppA subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 495495Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase HAMAP-Rule MF_01550
PRO_0000318615

Sequences

Sequence LengthMass (Da)Tools
A4WG31 [UniParc].

Last modified May 29, 2007. Version 1.
Checksum: 4E0CD34925F89C73

FASTA49555,115
        10         20         30         40         50         60 
MMITGSSLYA AIDLGSNSFH MLVVREVAGS IQTLTRIKRK VRLAAGLSQD NHLSPEAMER 

        70         80         90        100        110        120 
GWQCLRLFAE RLQDIPHNQI RVVATATLRL AVNSVDFIAK AQEILGCPVQ VISGEEEARL 

       130        140        150        160        170        180 
IYQGVAHTTG GDDRRLVVDI GGASTELVTG TGAQATSLFS LSMGCVTWLE RYFTDRNLAQ 

       190        200        210        220        230        240 
ENFDEAENAA REVLRPVMDK LRYHGWKVCV GASGTVQALQ EIMMAQGMDE RITLAKLQQL 

       250        260        270        280        290        300 
KQRAIQCGRL EELEIEGLTL ERALVFPSGL AILIAIFSEL DIHCMTLAGG ALREGLVYGM 

       310        320        330        340        350        360 
LHLAVEQDIR SRTLRNVQRR FIVDTEQAQR VAQLASSFAN QLKTTWALEP LSQDLLISAC 

       370        380        390        400        410        420 
ALHEMGLSID FKQAPIHAAY LVRNLDLPGF TPAQKKLLAT LLLNQTNTVD LSSLHQQNAV 

       430        440        450        460        470        480 
PPRVAEHLCR LLRLAILFAS RRRDDLLPAI KLEAEGENLT LTLPEDWLDN HPLGAEMIEQ 

       490 
EYQWQSYVHW ALEVK 

« Hide

References

[1]"Genome sequence of the plant growth promoting endophytic bacterium Enterobacter sp. 638."
Taghavi S., van der Lelie D., Hoffman A., Zhang Y.B., Walla M.D., Vangronsveld J., Newman L., Monchy S.
PLoS Genet. 6:E1000943-E1000943(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 638.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000653 Genomic DNA. Translation: ABP62661.1.
RefSeqYP_001178712.1. NC_009436.1.

3D structure databases

ProteinModelPortalA4WG31.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING399742.Ent638_4006.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABP62661; ABP62661; Ent638_4006.
GeneID5110471.
KEGGent:Ent638_4006.
PATRIC20417781. VBIEntSp101211_4170.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0248.
HOGENOMHOG000258672.
KOK01524.
OMASYVHWAL.
OrthoDBEOG6M6JN6.

Enzyme and pathway databases

BioCycESP399742:GJ0E-4103-MONOMER.
UniPathwayUPA00908; UER00884.

Family and domain databases

HAMAPMF_01550. GppA.
InterProIPR023709. Guo-5TP_3DP_PyrP.
IPR003695. Ppx_GppA.
[Graphical view]
PfamPF02541. Ppx-GppA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGPPA_ENT38
AccessionPrimary (citable) accession number: A4WG31
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: May 29, 2007
Last modified: May 14, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways