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A4WG31

- GPPA_ENT38

UniProt

A4WG31 - GPPA_ENT38

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Protein

Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase

Gene

gppA

Organism
Enterobacter sp. (strain 638)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities.UniRule annotation

Catalytic activityi

Guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. guanosine pentaphosphate catabolic process Source: InterPro
  2. guanosine tetraphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciESP399742:GJ0E-4103-MONOMER.
UniPathwayiUPA00908; UER00884.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanosine-5'-triphosphate,3'-diphosphate pyrophosphataseUniRule annotation (EC:3.6.1.40UniRule annotation)
Alternative name(s):
Guanosine pentaphosphate phosphohydrolaseUniRule annotation
pppGpp-5'-phosphohydrolaseUniRule annotation
Gene namesi
Name:gppAUniRule annotation
Ordered Locus Names:Ent638_4006
OrganismiEnterobacter sp. (strain 638)
Taxonomic identifieri399742 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEnterobacter
ProteomesiUP000000230: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 495495Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatasePRO_0000318615Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi399742.Ent638_4006.

Structurei

3D structure databases

ProteinModelPortaliA4WG31.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GppA/Ppx family. GppA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0248.
HOGENOMiHOG000258672.
KOiK01524.
OMAiSYVHWAL.
OrthoDBiEOG6M6JN6.

Family and domain databases

HAMAPiMF_01550. GppA.
InterProiIPR023709. Guo-5TP_3DP_PyrP.
IPR003695. Ppx_GppA.
[Graphical view]
PfamiPF02541. Ppx-GppA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4WG31 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMITGSSLYA AIDLGSNSFH MLVVREVAGS IQTLTRIKRK VRLAAGLSQD
60 70 80 90 100
NHLSPEAMER GWQCLRLFAE RLQDIPHNQI RVVATATLRL AVNSVDFIAK
110 120 130 140 150
AQEILGCPVQ VISGEEEARL IYQGVAHTTG GDDRRLVVDI GGASTELVTG
160 170 180 190 200
TGAQATSLFS LSMGCVTWLE RYFTDRNLAQ ENFDEAENAA REVLRPVMDK
210 220 230 240 250
LRYHGWKVCV GASGTVQALQ EIMMAQGMDE RITLAKLQQL KQRAIQCGRL
260 270 280 290 300
EELEIEGLTL ERALVFPSGL AILIAIFSEL DIHCMTLAGG ALREGLVYGM
310 320 330 340 350
LHLAVEQDIR SRTLRNVQRR FIVDTEQAQR VAQLASSFAN QLKTTWALEP
360 370 380 390 400
LSQDLLISAC ALHEMGLSID FKQAPIHAAY LVRNLDLPGF TPAQKKLLAT
410 420 430 440 450
LLLNQTNTVD LSSLHQQNAV PPRVAEHLCR LLRLAILFAS RRRDDLLPAI
460 470 480 490
KLEAEGENLT LTLPEDWLDN HPLGAEMIEQ EYQWQSYVHW ALEVK
Length:495
Mass (Da):55,115
Last modified:May 29, 2007 - v1
Checksum:i4E0CD34925F89C73
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000653 Genomic DNA. Translation: ABP62661.1.
RefSeqiWP_015960965.1. NC_009436.1.
YP_001178712.1. NC_009436.1.

Genome annotation databases

EnsemblBacteriaiABP62661; ABP62661; Ent638_4006.
GeneIDi5110471.
KEGGient:Ent638_4006.
PATRICi20417781. VBIEntSp101211_4170.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000653 Genomic DNA. Translation: ABP62661.1 .
RefSeqi WP_015960965.1. NC_009436.1.
YP_001178712.1. NC_009436.1.

3D structure databases

ProteinModelPortali A4WG31.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 399742.Ent638_4006.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABP62661 ; ABP62661 ; Ent638_4006 .
GeneIDi 5110471.
KEGGi ent:Ent638_4006.
PATRICi 20417781. VBIEntSp101211_4170.

Phylogenomic databases

eggNOGi COG0248.
HOGENOMi HOG000258672.
KOi K01524.
OMAi SYVHWAL.
OrthoDBi EOG6M6JN6.

Enzyme and pathway databases

UniPathwayi UPA00908 ; UER00884 .
BioCyci ESP399742:GJ0E-4103-MONOMER.

Family and domain databases

HAMAPi MF_01550. GppA.
InterProi IPR023709. Guo-5TP_3DP_PyrP.
IPR003695. Ppx_GppA.
[Graphical view ]
Pfami PF02541. Ppx-GppA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the plant growth promoting endophytic bacterium Enterobacter sp. 638."
    Taghavi S., van der Lelie D., Hoffman A., Zhang Y.B., Walla M.D., Vangronsveld J., Newman L., Monchy S.
    PLoS Genet. 6:E1000943-E1000943(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 638.

Entry informationi

Entry nameiGPPA_ENT38
AccessioniPrimary (citable) accession number: A4WG31
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: May 29, 2007
Last modified: October 1, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3