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Protein

HTH-type transcriptional regulator MalT

Gene

malT

Organism
Enterobacter sp. (strain 638)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto-oligosaccharides. Binds and recognizes a DNA motif (called the malT box): 5'-GGA[TG]GA-3'.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi39 – 46ATPUniRule annotation8
DNA bindingi853 – 872H-T-H motifUniRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Carbohydrate metabolism, Transcription, Transcription regulation

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator MalTUniRule annotation
Alternative name(s):
ATP-dependent transcriptional activator MalTUniRule annotation
Gene namesi
Name:malTUniRule annotation
Ordered Locus Names:Ent638_3831
OrganismiEnterobacter sp. (strain 638)
Taxonomic identifieri399742 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEnterobacter
Proteomesi
  • UP000000230 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000857711 – 901HTH-type transcriptional regulator MalTAdd BLAST901

Interactioni

Subunit structurei

Monomer in solution but oligomerizes to an active state in the presence of the positive effectors ATP and maltotriose.UniRule annotation

Protein-protein interaction databases

STRINGi399742.Ent638_3831.

Structurei

3D structure databases

ProteinModelPortaliA4WFK6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini829 – 894HTH luxR-typeUniRule annotationAdd BLAST66

Sequence similaritiesi

Contains 1 HTH luxR-type DNA-binding domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG41061ZR. Bacteria.
COG2909. LUCA.
HOGENOMiHOG000218261.
KOiK03556.
OMAiSDWVSNA.

Family and domain databases

CDDicd06170. LuxR_C_like. 1 hit.
Gene3Di1.10.10.10. 1 hit.
1.25.40.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_01247. HTH_type_MalT. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR016032. Sig_transdc_resp-reg_C-effctor.
IPR011990. TPR-like_helical_dom.
IPR023768. Tscrpt_reg_HTH_MalT.
IPR000792. Tscrpt_reg_LuxR_C.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00196. GerE. 1 hit.
[Graphical view]
PRINTSiPR00038. HTHLUXR.
SMARTiSM00421. HTH_LUXR. 1 hit.
[Graphical view]
SUPFAMiSSF46894. SSF46894. 1 hit.
SSF48452. SSF48452. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00622. HTH_LUXR_1. 1 hit.
PS50043. HTH_LUXR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4WFK6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLIPSKLSRP VRLDHTVVRE RLLAKLSGAN NFRLALITSP AGYGKTTLIS
60 70 80 90 100
QWASGKSDLG WYSLDEGDNQ TERFASYLIA AIQQATNGHC VTSEIMVQKR
110 120 130 140 150
QYASLSSLFA QLFIELAEWH RPLYLVIDDY HLITNPVIHE SMRFFLRHQP
160 170 180 190 200
ENLTLVVLSR NLPQLGIANL RVRDQLLEVG SQQLSFNHQE AKQFFDCRLS
210 220 230 240 250
SPIEAAESSR LCDDVAGWAT ALQLIALSAR QNNSPTHQSA RRLSGINASH
260 270 280 290 300
LSDYLVDEVL DSVDPATRQF LLKSSLLRSM NDALIVRVTG EDNGQMRLEE
310 320 330 340 350
IERQGLFLQR MDDSGEWFSF HPLFGSFLRQ RCQWELATEL PEVHRSAAES
360 370 380 390 400
WMAQGFPSEA IHHALAAGDA NMLRDILLNH AWGLFNHSEL TLLEESLRAL
410 420 430 440 450
PWESLLENPR LVLLQAWLMQ SQHRYSEVNM LLARAEQEMK GEMDPTLHGE
460 470 480 490 500
FNALRAQVAI NDGDPEEAER LAMIALDELP LANFYSRIVA TSVHGEVLHC
510 520 530 540 550
KGDLSRSLAL MQQTEQMARR HDIWHYALWS MIQQSEILFA QGFLQAAWET
560 570 580 590 600
QEKAFQLIHD QHLEQLPMHE FLLRIRAQLL WAWSRLDEAE SSARHGVEVL
610 620 630 640 650
SAFQPQQQLQ CLALLVQCSL ARGDLDNARN HLNRLENLLG NGQYHSDWVS
660 670 680 690 700
NADKVRVIYW QMIGDKKSAA NWLRQTPKPE FANNHFLQSQ WRNIARVQIL
710 720 730 740 750
LGDFDPAEIV LEELNENARS LRLMSDLNRN LLLLNQLYWQ AGRKNDAQRV
760 770 780 790 800
LLEALQLANR TGFISHFVIE GEVMAQQLRQ LIQLNTLPEL DQHRAQRILR
810 820 830 840 850
EINQHHRHKF AHFDENFVER LLTHPEVPEL IRTSPLTQRE WQVLGLIYSG
860 870 880 890 900
YSNEQIAGEL AVAATTIKTH IRNLYQKLGV AHRQDAVQHA QQLLKMMGYG

V
Length:901
Mass (Da):103,261
Last modified:May 29, 2007 - v1
Checksum:iF9DEB83E3F1C1370
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000653 Genomic DNA. Translation: ABP62486.1.
RefSeqiWP_015960791.1. NC_009436.1.

Genome annotation databases

EnsemblBacteriaiABP62486; ABP62486; Ent638_3831.
KEGGient:Ent638_3831.
PATRICi20417409. VBIEntSp101211_3993.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000653 Genomic DNA. Translation: ABP62486.1.
RefSeqiWP_015960791.1. NC_009436.1.

3D structure databases

ProteinModelPortaliA4WFK6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi399742.Ent638_3831.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABP62486; ABP62486; Ent638_3831.
KEGGient:Ent638_3831.
PATRICi20417409. VBIEntSp101211_3993.

Phylogenomic databases

eggNOGiENOG41061ZR. Bacteria.
COG2909. LUCA.
HOGENOMiHOG000218261.
KOiK03556.
OMAiSDWVSNA.

Family and domain databases

CDDicd06170. LuxR_C_like. 1 hit.
Gene3Di1.10.10.10. 1 hit.
1.25.40.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_01247. HTH_type_MalT. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR016032. Sig_transdc_resp-reg_C-effctor.
IPR011990. TPR-like_helical_dom.
IPR023768. Tscrpt_reg_HTH_MalT.
IPR000792. Tscrpt_reg_LuxR_C.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00196. GerE. 1 hit.
[Graphical view]
PRINTSiPR00038. HTHLUXR.
SMARTiSM00421. HTH_LUXR. 1 hit.
[Graphical view]
SUPFAMiSSF46894. SSF46894. 1 hit.
SSF48452. SSF48452. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00622. HTH_LUXR_1. 1 hit.
PS50043. HTH_LUXR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMALT_ENT38
AccessioniPrimary (citable) accession number: A4WFK6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 29, 2007
Last modified: November 2, 2016
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.