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Protein

Methionyl-tRNA formyltransferase

Gene

fmt

Organism
Enterobacter sp. (strain 638)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.UniRule annotation

Catalytic activityi

10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = tetrahydrofolate + N-formylmethionyl-tRNA(fMet).UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionTransferase
Biological processProtein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Methionyl-tRNA formyltransferaseUniRule annotation (EC:2.1.2.9UniRule annotation)
Gene namesi
Name:fmtUniRule annotation
Ordered Locus Names:Ent638_3719
OrganismiEnterobacter sp. (strain 638)
Taxonomic identifieri399742 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEnterobacter
Proteomesi
  • UP000000230 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000584021 – 315Methionyl-tRNA formyltransferaseAdd BLAST315

Proteomic databases

PRIDEiA4WF96

Interactioni

Protein-protein interaction databases

STRINGi399742.Ent638_3719

Structurei

3D structure databases

ProteinModelPortaliA4WF96
SMRiA4WF96
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni113 – 116Tetrahydrofolate (THF) bindingUniRule annotation4

Sequence similaritiesi

Belongs to the Fmt family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CAE Bacteria
COG0223 LUCA
HOGENOMiHOG000261177
KOiK00604
OMAiLRIVFMG

Family and domain databases

Gene3Di3.10.25.10, 1 hit
HAMAPiMF_00182 Formyl_trans, 1 hit
InterProiView protein in InterPro
IPR005794 Fmt
IPR005793 Formyl_trans_C
IPR037022 Formyl_trans_C_sf
IPR002376 Formyl_transf_N
IPR036477 Formyl_transf_N_sf
IPR011034 Formyl_transferase-like_C_sf
IPR001555 GART_AS
PfamiView protein in Pfam
PF02911 Formyl_trans_C, 1 hit
PF00551 Formyl_trans_N, 1 hit
SUPFAMiSSF50486 SSF50486, 1 hit
SSF53328 SSF53328, 1 hit
TIGRFAMsiTIGR00460 fmt, 1 hit
PROSITEiView protein in PROSITE
PS00373 GART, 1 hit

Sequencei

Sequence statusi: Complete.

A4WF96-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKKLRIIFA GTPDFAARHL DALLSSGHQI VGVFTQPDRP AGRGKKLMPG
60 70 80 90 100
PVKVLAEKHN LPVFQPVSLR PQENQQLVSD LNADVMVVVA YGLILPKAVL
110 120 130 140 150
DMPRLGCINV HGSLLPRWRG AAPIQRSLWA GDSETGVTIM RMDVGLDTGD
160 170 180 190 200
MLYKLACPIT AEDTSATLYD KLADLGPQGL IETLQQLADG KAQPEVQDEA
210 220 230 240 250
FVTYAEKLSK EEAQLDWSLS AAQLERCIRA FNPWPMSWMT IDEQPVKIWK
260 270 280 290 300
ASVINREAKA EPGTIIEATR EGIQVATADG ILNLESLQPA GKKAMSAQDL
310
LNSRREWFTP GTRLA
Length:315
Mass (Da):34,528
Last modified:May 29, 2007 - v1
Checksum:iB148D24ECA861596
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000653 Genomic DNA Translation: ABP62376.1
RefSeqiWP_015960697.1, NC_009436.1

Genome annotation databases

EnsemblBacteriaiABP62376; ABP62376; Ent638_3719
GeneIDi32444434
KEGGient:Ent638_3719

Similar proteinsi

Entry informationi

Entry nameiFMT_ENT38
AccessioniPrimary (citable) accession number: A4WF96
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 29, 2007
Last modified: March 28, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health