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A4WER8 (RLMG_ENT38) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ribosomal RNA large subunit methyltransferase G
EC=2.1.1.174
Alternative name(s):
23S rRNA m2G1835 methyltransferase
rRNA (guanine-N(2)-)-methyltransferase RlmG
Gene names
Name:rlmG
Ordered Locus Names:Ent638_3540
OrganismEnterobacter sp. (strain 638) [Complete proteome] [HAMAP]
Taxonomic identifier399742 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Enterobacter

Protein attributes

Sequence length378 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Specifically methylates the guanosine in position 1835 (m2G1835) of 23S rRNA By similarity. HAMAP MF_01859

Catalytic activity

S-adenosyl-L-methionine + guanosine(1835) in 23S rRNA = S-adenosyl-L-homocysteine + N(2)-methylguanosine(1835) in 23S rRNA. HAMAP MF_01859

Subcellular location

Cytoplasm Potential HAMAP MF_01859.

Sequence similarities

Belongs to the methyltransferase superfamily. RlmG family.

Ontologies

Keywords
   Biological processrRNA processing
   Cellular componentCytoplasm
   LigandS-adenosyl-L-methionine
   Molecular functionMethyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionnucleic acid binding

Inferred from electronic annotation. Source: InterPro

rRNA (guanine-N2-)-methyltransferase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 378378Ribosomal RNA large subunit methyltransferase G HAMAP MF_01859
PRO_0000366452

Sequences

Sequence LengthMass (Da)Tools
A4WER8 [UniParc].

Last modified May 29, 2007. Version 1.
Checksum: AD9150609122FA13

FASTA37842,231
        10         20         30         40         50         60 
MSHLDNGFRS LNLKRFPETD DVNPLQAWEA ADEYLLQQLD DTEISGPVLV LNDVFGALAC 

        70         80         90        100        110        120 
ALAEHTPYSI GDSYLSELAT RENLRHNEIA ESSVKFLDST AEYPQAPGVV LIKIPKTLAL 

       130        140        150        160        170        180 
LEQQLRALRL VVTPQTRIIA GAKARDIHNS TLELFEKILG TTTTTLAWKK ARLINCTFTE 

       190        200        210        220        230        240 
PALVDAQQML SWKLEGTDWT IHNHANVFSR TGLDIGARFF LEHLPGNLEG EIVDLGCGNG 

       250        260        270        280        290        300 
VVGLTLLEKN PEASVLFTDE SPMAVASSRL NVETNMPEAL DRCEFMINNA LSGVEPFRFN 

       310        320        330        340        350        360 
AVLCNPPFHQ QHALTDNVAW EMFHHARRCL KINGELYIVA NRHLDYFHKL KKIFGNCTTI 

       370 
ATNNKFVVLK AVKLGRTR

« Hide

References

[1]"Complete sequence of chromosome of Enterobacter sp. 638."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Detter J.C., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Kim E., Taghavi S., Newman L., Vangronsveld J., van der Lelie D., Richardson P.
Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 638.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000653 Genomic DNA. Translation: ABP62198.1.
RefSeqYP_001178249.1. NC_009436.1.

3D structure databases

ProteinModelPortalA4WER8.
ModBaseSearch...

Protein-protein interaction databases

STRINGA4WER8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5112771.
GenomeReviewsGene locus Ent638_3540 in contig CP000653_GR.
KEGGent:Ent638_3540.
NMPDRfig|399742.4.peg.3360.
PATRIC20416805. VBIEntSp101211_3699.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2813.
HOGENOMHBG321931.
OMANRHLGYH.
PhylomeDBA4WER8.
ProtClustDBPRK15001.

Enzyme and pathway databases

BioCycESP42895:ENT638_3540-MONOMER.

Family and domain databases

HAMAPMF_01859. 23SrRNA_methyltr_G.
[Tree]
InterProIPR002052. DNA_methylase_N6_adenine_CS.
IPR017237. rRNA_m2G-MeTrfase_RsmD.
IPR007848. Small_mtfrase.
[Graphical view]
KOK11391.
PfamPF05175. MTS. 1 hit.
[Graphical view]
PIRSFPIRSF037565. RRNA_m2G_Mtase_RsmD_prd. 1 hit.
ProtoNetSearch...

Entry information

Entry nameRLMG_ENT38
AccessionPrimary (citable) accession number: A4WER8
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: May 29, 2007
Last modified: January 25, 2012
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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