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Protein

Putrescine aminotransferase

Gene

patA

Organism
Enterobacter sp. (strain 638)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the aminotransferase reaction from putrescine to 2-oxoglutarate, leading to glutamate and 4-aminobutanal, which spontaneously cyclizes to form 1-pyrroline. Is also able to transaminate cadaverine and, in lower extent, spermidine, but not ornithine.UniRule annotation

Catalytic activityi

Putrescine + 2-oxoglutarate = L-glutamate + 1-pyrroline + H2O.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: putrescine degradation

This protein is involved in step 1 of the subpathway that synthesizes 4-aminobutanal from putrescine (transaminase route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Putrescine aminotransferase (patA)
This subpathway is part of the pathway putrescine degradation, which is itself part of Amine and polyamine degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 4-aminobutanal from putrescine (transaminase route), the pathway putrescine degradation and in Amine and polyamine degradation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase
LigandPyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00188; UER00290

Names & Taxonomyi

Protein namesi
Recommended name:
Putrescine aminotransferaseUniRule annotation (EC:2.6.1.82UniRule annotation)
Alternative name(s):
Putrescine--2-oxoglutaric acid transaminaseUniRule annotation
Short name:
PATUniRule annotation
Short name:
PATaseUniRule annotation
Gene namesi
Name:patAUniRule annotation
Ordered Locus Names:Ent638_3528
OrganismiEnterobacter sp. (strain 638)
Taxonomic identifieri399742 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEnterobacter
Proteomesi
  • UP000000230 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000673971 – 459Putrescine aminotransferaseAdd BLAST459

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei300N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Protein-protein interaction databases

STRINGi399742.Ent638_3528

Structurei

3D structure databases

ProteinModelPortaliA4WEQ6
SMRiA4WEQ6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. Putrescine aminotransferase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8Y Bacteria
COG4992 LUCA
HOGENOMiHOG000020206
KOiK09251
OMAiLIHGQYT

Family and domain databases

CDDicd00610 OAT_like, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_01276 Putres_aminotrans_3, 1 hit
InterProiView protein in InterPro
IPR005814 Aminotrans_3
IPR017747 Putrescine_aminotransferase
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00202 Aminotran_3, 1 hit
PIRSFiPIRSF000521 Transaminase_4ab_Lys_Orn, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR03372 putres_am_tran, 1 hit
PROSITEiView protein in PROSITE
PS00600 AA_TRANSFER_CLASS_3, 1 hit

Sequencei

Sequence statusi: Complete.

A4WEQ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNRLPSSASA LACTAHALNL IEKRTLDHEE MKQLNREVID YFKEHVNPGF
60 70 80 90 100
LEYRKSVTAG GDYGAVEWQA GSLNTLVDTQ GQEFIDCLGG FGIFNVGHRN
110 120 130 140 150
PVVVSAVQNQ LAKQPLHSQE LLDPLRAMLA KTLAALTPGK LKYSFFSNSG
160 170 180 190 200
TESVEAALKL AKAYQSPRGK FTFIATSGAF HGKSLGALSA TAKSTFRKPF
210 220 230 240 250
MPLLPGFRHV PFGDINAMRT MLTECRKTGD DVAAVILEPI QGEGGVILPP
260 270 280 290 300
LGYLPAVRKL CDEFDALLIL DEVQTGMGRT GKMFACEHEN VQPDILCLAK
310 320 330 340 350
ALGGGVMPIG ATVATEEVFS VLFDNPFLHT TTFGGNPLSC AAALATINVL
360 370 380 390 400
LEQNLPAQAE QKGDMLLDGF LQLGREYPDL VQDARGKGML IAIEFVDNEI
410 420 430 440 450
GYSFASEMFR QRILVAGTLN NSKTIRIEPP LTLTIEQCEQ VLKATRTALA

ALRVSVEEA
Length:459
Mass (Da):49,731
Last modified:May 29, 2007 - v1
Checksum:iE5034C8B7173783B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000653 Genomic DNA Translation: ABP62186.1

Genome annotation databases

EnsemblBacteriaiABP62186; ABP62186; Ent638_3528
KEGGient:Ent638_3528

Similar proteinsi

Entry informationi

Entry nameiPAT_ENT38
AccessioniPrimary (citable) accession number: A4WEQ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 29, 2007
Last modified: February 28, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health