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Protein

Putrescine aminotransferase

Gene

patA

Organism
Enterobacter sp. (strain 638)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the aminotransferase reaction from putrescine to 2-oxoglutarate, leading to glutamate and 4-aminobutanal, which spontaneously cyclizes to form 1-pyrroline. Is also able to transaminate cadaverine and, in lower extent, spermidine, but not ornithine.UniRule annotation

Catalytic activityi

Putrescine + 2-oxoglutarate = L-glutamate + 1-pyrroline + H2O.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: putrescine degradation

This protein is involved in step 1 of the subpathway that synthesizes 4-aminobutanal from putrescine (transaminase route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Putrescine aminotransferase (patA)
This subpathway is part of the pathway putrescine degradation, which is itself part of Amine and polyamine degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 4-aminobutanal from putrescine (transaminase route), the pathway putrescine degradation and in Amine and polyamine degradation.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00188; UER00290.

Names & Taxonomyi

Protein namesi
Recommended name:
Putrescine aminotransferaseUniRule annotation (EC:2.6.1.82UniRule annotation)
Alternative name(s):
Putrescine--2-oxoglutaric acid transaminaseUniRule annotation
Short name:
PATUniRule annotation
Short name:
PATaseUniRule annotation
Gene namesi
Name:patAUniRule annotation
Ordered Locus Names:Ent638_3528
OrganismiEnterobacter sp. (strain 638)
Taxonomic identifieri399742 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEnterobacter
Proteomesi
  • UP000000230 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000673971 – 459Putrescine aminotransferaseAdd BLAST459

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei300N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Protein-protein interaction databases

STRINGi399742.Ent638_3528.

Structurei

3D structure databases

ProteinModelPortaliA4WEQ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. Putrescine aminotransferase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8Y. Bacteria.
COG4992. LUCA.
HOGENOMiHOG000020206.
KOiK09251.
OMAiTHDHTIR.

Family and domain databases

CDDicd00610. OAT_like. 1 hit.
Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01276. Putres_aminotrans_3. 1 hit.
InterProiIPR005814. Aminotrans_3.
IPR017747. Putrescine_aminotransferase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR03372. putres_am_tran. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4WEQ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNRLPSSASA LACTAHALNL IEKRTLDHEE MKQLNREVID YFKEHVNPGF
60 70 80 90 100
LEYRKSVTAG GDYGAVEWQA GSLNTLVDTQ GQEFIDCLGG FGIFNVGHRN
110 120 130 140 150
PVVVSAVQNQ LAKQPLHSQE LLDPLRAMLA KTLAALTPGK LKYSFFSNSG
160 170 180 190 200
TESVEAALKL AKAYQSPRGK FTFIATSGAF HGKSLGALSA TAKSTFRKPF
210 220 230 240 250
MPLLPGFRHV PFGDINAMRT MLTECRKTGD DVAAVILEPI QGEGGVILPP
260 270 280 290 300
LGYLPAVRKL CDEFDALLIL DEVQTGMGRT GKMFACEHEN VQPDILCLAK
310 320 330 340 350
ALGGGVMPIG ATVATEEVFS VLFDNPFLHT TTFGGNPLSC AAALATINVL
360 370 380 390 400
LEQNLPAQAE QKGDMLLDGF LQLGREYPDL VQDARGKGML IAIEFVDNEI
410 420 430 440 450
GYSFASEMFR QRILVAGTLN NSKTIRIEPP LTLTIEQCEQ VLKATRTALA

ALRVSVEEA
Length:459
Mass (Da):49,731
Last modified:May 29, 2007 - v1
Checksum:iE5034C8B7173783B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000653 Genomic DNA. Translation: ABP62186.1.

Genome annotation databases

EnsemblBacteriaiABP62186; ABP62186; Ent638_3528.
KEGGient:Ent638_3528.
PATRICi20416781. VBIEntSp101211_3687.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000653 Genomic DNA. Translation: ABP62186.1.

3D structure databases

ProteinModelPortaliA4WEQ6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi399742.Ent638_3528.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABP62186; ABP62186; Ent638_3528.
KEGGient:Ent638_3528.
PATRICi20416781. VBIEntSp101211_3687.

Phylogenomic databases

eggNOGiENOG4105C8Y. Bacteria.
COG4992. LUCA.
HOGENOMiHOG000020206.
KOiK09251.
OMAiTHDHTIR.

Enzyme and pathway databases

UniPathwayiUPA00188; UER00290.

Family and domain databases

CDDicd00610. OAT_like. 1 hit.
Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01276. Putres_aminotrans_3. 1 hit.
InterProiIPR005814. Aminotrans_3.
IPR017747. Putrescine_aminotransferase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR03372. putres_am_tran. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPAT_ENT38
AccessioniPrimary (citable) accession number: A4WEQ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 29, 2007
Last modified: November 2, 2016
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.