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A4WE55

- GCSP_ENT38

UniProt

A4WE55 - GCSP_ENT38

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Protein

Glycine dehydrogenase (decarboxylating)

Gene
gcvP, Ent638_3322
Organism
Enterobacter sp. (strain 638)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciESP399742:GJ0E-3400-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
Ordered Locus Names:Ent638_3322
OrganismiEnterobacter sp. (strain 638)
Taxonomic identifieri399742 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEnterobacter
ProteomesiUP000000230: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 957957Glycine dehydrogenase (decarboxylating)UniRule annotationPRO_1000062076Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei708 – 7081N6-(pyridoxal phosphate)lysine By similarity

Proteomic databases

PRIDEiA4WE55.

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi399742.Ent638_3322.

Structurei

3D structure databases

ProteinModelPortaliA4WE55.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiFDSRPYS.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

A4WE55-1 [UniParc]FASTAAdd to Basket

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MTQTLSQLEN RGAFIERHIG PDAQQQQEML KTVGADSLNA LIGQIVPKDI    50
QLATPPQVGE ATTEFAALAE LKAIAGLNKR FKSYIGMGYT PVQLPPVILR 100
NMLENPGWYT AYTPYQPEVS QGRLEALLNF QQVTLDLTGL DIASASLLDE 150
ATAAAEAMAM AKRVSKLKNA NRFFVAADVH PQTLDVVRTR AETFGFDVIV 200
DDADKVLDHQ DVFGVLLQQV GTTGEVHDYS ALISELKSRK IIVSVAADFM 250
ALVLLTAPGK QGADIVFGSA QRFGVPMGYG GPHAAFFAGK DEFKRSMPGR 300
IIGVSKDAAG NTALRMAMQT REQHIRREKA NSNICTSQVL LANIASLYAV 350
FHGPVGLKRI ATRIHRFADI LATGLQQKGL KLRHAHYFDT LCVEVADKAG 400
VLARAEAAEI NLRSDILNAV GITLDETTTR EDVQNLFNVL LGDAHGLDVD 450
ALDKEVAHDS RSIQESMLRD DAILSHPVFN RHHSETEMMR YMHSLERKDL 500
ALNQAMIPLG SCTMKLNAAA EMIPITWPEF SELHPFCPAD QAEGYHQMIN 550
QLSDWLVKLT GYDALCMQPN SGAQGEYAGL LAIRHYHESR NEGHRDICLI 600
PSSAHGTNPA SAQMAGMEVV VVACDKNGNI DLTDLRAKAE HAGEKLSCIM 650
VTYPSTHGVY EETIREVCEI VHQFGGQVYL DGANMNAQVG ITSPGFIGAD 700
VSHLNLHKTF CIPHGGGGPG MGPIGVKAHL APFVPGHSVV QIEGMLTRQG 750
AVSAAPFGSA SILPISWMYI RMMGAEGLKQ ASQVAILNAN YIATRLKDAY 800
PVLYTGRDGR VAHECILDIR PLKDDTGISE LDIAKRLIDY GFHAPTMSFP 850
VAGTLMVEPT ESESKVELDR FIEAMLAIRH EITRVKQGEW TLEDNPLVNA 900
PHTQNELVAE WHHGYTREVA VFPAGMANKY WPTVKRLDDV YGDRNLFCSC 950
VPMSEYQ 957
Length:957
Mass (Da):104,745
Last modified:May 29, 2007 - v1
Checksum:i3F6EAAD4B561D2B5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000653 Genomic DNA. Translation: ABP61985.1.
RefSeqiWP_015960313.1. NC_009436.1.
YP_001178036.1. NC_009436.1.

Genome annotation databases

EnsemblBacteriaiABP61985; ABP61985; Ent638_3322.
GeneIDi5111836.
KEGGient:Ent638_3322.
PATRICi20416369. VBIEntSp101211_3483.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000653 Genomic DNA. Translation: ABP61985.1 .
RefSeqi WP_015960313.1. NC_009436.1.
YP_001178036.1. NC_009436.1.

3D structure databases

ProteinModelPortali A4WE55.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 399742.Ent638_3322.

Proteomic databases

PRIDEi A4WE55.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABP61985 ; ABP61985 ; Ent638_3322 .
GeneIDi 5111836.
KEGGi ent:Ent638_3322.
PATRICi 20416369. VBIEntSp101211_3483.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi FDSRPYS.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci ESP399742:GJ0E-3400-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the plant growth promoting endophytic bacterium Enterobacter sp. 638."
    Taghavi S., van der Lelie D., Hoffman A., Zhang Y.B., Walla M.D., Vangronsveld J., Newman L., Monchy S.
    PLoS Genet. 6:E1000943-E1000943(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 638.

Entry informationi

Entry nameiGCSP_ENT38
AccessioniPrimary (citable) accession number: A4WE55
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 29, 2007
Last modified: September 3, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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