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A4WE55

- GCSP_ENT38

UniProt

A4WE55 - GCSP_ENT38

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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Enterobacter sp. (strain 638)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciESP399742:GJ0E-3400-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:Ent638_3322
OrganismiEnterobacter sp. (strain 638)
Taxonomic identifieri399742 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEnterobacter
ProteomesiUP000000230: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 957957Glycine dehydrogenase (decarboxylating)PRO_1000062076Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei708 – 7081N6-(pyridoxal phosphate)lysineUniRule annotation

Proteomic databases

PRIDEiA4WE55.

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi399742.Ent638_3322.

Structurei

3D structure databases

ProteinModelPortaliA4WE55.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiFDSRPYS.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

A4WE55-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTQTLSQLEN RGAFIERHIG PDAQQQQEML KTVGADSLNA LIGQIVPKDI
60 70 80 90 100
QLATPPQVGE ATTEFAALAE LKAIAGLNKR FKSYIGMGYT PVQLPPVILR
110 120 130 140 150
NMLENPGWYT AYTPYQPEVS QGRLEALLNF QQVTLDLTGL DIASASLLDE
160 170 180 190 200
ATAAAEAMAM AKRVSKLKNA NRFFVAADVH PQTLDVVRTR AETFGFDVIV
210 220 230 240 250
DDADKVLDHQ DVFGVLLQQV GTTGEVHDYS ALISELKSRK IIVSVAADFM
260 270 280 290 300
ALVLLTAPGK QGADIVFGSA QRFGVPMGYG GPHAAFFAGK DEFKRSMPGR
310 320 330 340 350
IIGVSKDAAG NTALRMAMQT REQHIRREKA NSNICTSQVL LANIASLYAV
360 370 380 390 400
FHGPVGLKRI ATRIHRFADI LATGLQQKGL KLRHAHYFDT LCVEVADKAG
410 420 430 440 450
VLARAEAAEI NLRSDILNAV GITLDETTTR EDVQNLFNVL LGDAHGLDVD
460 470 480 490 500
ALDKEVAHDS RSIQESMLRD DAILSHPVFN RHHSETEMMR YMHSLERKDL
510 520 530 540 550
ALNQAMIPLG SCTMKLNAAA EMIPITWPEF SELHPFCPAD QAEGYHQMIN
560 570 580 590 600
QLSDWLVKLT GYDALCMQPN SGAQGEYAGL LAIRHYHESR NEGHRDICLI
610 620 630 640 650
PSSAHGTNPA SAQMAGMEVV VVACDKNGNI DLTDLRAKAE HAGEKLSCIM
660 670 680 690 700
VTYPSTHGVY EETIREVCEI VHQFGGQVYL DGANMNAQVG ITSPGFIGAD
710 720 730 740 750
VSHLNLHKTF CIPHGGGGPG MGPIGVKAHL APFVPGHSVV QIEGMLTRQG
760 770 780 790 800
AVSAAPFGSA SILPISWMYI RMMGAEGLKQ ASQVAILNAN YIATRLKDAY
810 820 830 840 850
PVLYTGRDGR VAHECILDIR PLKDDTGISE LDIAKRLIDY GFHAPTMSFP
860 870 880 890 900
VAGTLMVEPT ESESKVELDR FIEAMLAIRH EITRVKQGEW TLEDNPLVNA
910 920 930 940 950
PHTQNELVAE WHHGYTREVA VFPAGMANKY WPTVKRLDDV YGDRNLFCSC

VPMSEYQ
Length:957
Mass (Da):104,745
Last modified:May 29, 2007 - v1
Checksum:i3F6EAAD4B561D2B5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000653 Genomic DNA. Translation: ABP61985.1.
RefSeqiWP_015960313.1. NC_009436.1.
YP_001178036.1. NC_009436.1.

Genome annotation databases

EnsemblBacteriaiABP61985; ABP61985; Ent638_3322.
GeneIDi5111836.
KEGGient:Ent638_3322.
PATRICi20416369. VBIEntSp101211_3483.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000653 Genomic DNA. Translation: ABP61985.1 .
RefSeqi WP_015960313.1. NC_009436.1.
YP_001178036.1. NC_009436.1.

3D structure databases

ProteinModelPortali A4WE55.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 399742.Ent638_3322.

Proteomic databases

PRIDEi A4WE55.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABP61985 ; ABP61985 ; Ent638_3322 .
GeneIDi 5111836.
KEGGi ent:Ent638_3322.
PATRICi 20416369. VBIEntSp101211_3483.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi FDSRPYS.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci ESP399742:GJ0E-3400-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the plant growth promoting endophytic bacterium Enterobacter sp. 638."
    Taghavi S., van der Lelie D., Hoffman A., Zhang Y.B., Walla M.D., Vangronsveld J., Newman L., Monchy S.
    PLoS Genet. 6:E1000943-E1000943(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 638.

Entry informationi

Entry nameiGCSP_ENT38
AccessioniPrimary (citable) accession number: A4WE55
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 29, 2007
Last modified: November 26, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3