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A4WDZ5 (ARGA_ENT38) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Amino-acid acetyltransferase
EC=2.3.1.1
Alternative name(s):
N-acetylglutamate synthase
Short name=AGS
Short name=NAGS
Gene names
Name:argA
Ordered Locus Names:Ent638_3261
OrganismEnterobacter sp. (strain 638) [Complete proteome] [HAMAP]
Taxonomic identifier399742 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Enterobacter

Protein attributes

Sequence length443 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Acetyl-CoA + L-glutamate = CoA + N-acetyl-L-glutamate. HAMAP-Rule MF_01105

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 1/4. HAMAP-Rule MF_01105

Subunit structure

Homohexamer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the acetyltransferase family. ArgA subfamily.

Contains 1 N-acetyltransferase domain.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Arginine biosynthesis
   Cellular componentCytoplasm
   Molecular functionAcyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processarginine biosynthetic process

Inferred from electronic annotation. Source: HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionacetyl-CoA:L-glutamate N-acetyltransferase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 443443Amino-acid acetyltransferase HAMAP-Rule MF_01105
PRO_1000084811

Regions

Domain296 – 435140N-acetyltransferase

Sequences

Sequence LengthMass (Da)Tools
A4WDZ5 [UniParc].

Last modified May 29, 2007. Version 1.
Checksum: 35DC83652E8DF5A6

FASTA44349,372
        10         20         30         40         50         60 
MVKERRTELV QGFRHSVPYI NTHRGKTFVI MLGGEAIEHE NFSSIVNDIG LLHSLGIRLV 

        70         80         90        100        110        120 
VVYGARPQID ANLAAHHHEP IYHKHTRVTD AKTLELVKQA AGLLQLDITA RLSMSLNNTP 

       130        140        150        160        170        180 
LQGAHINVVS GNFIISQPLG VDDGVDYCHS GRIRRIDEEA IHRQLDSGAI VLMGPVAVSV 

       190        200        210        220        230        240 
TGESFNLTSE EVATQLAIKL KAEKMIGFCS SQGVFDEQGN IVSELFPNEA QARVETLEAE 

       250        260        270        280        290        300 
GDYHSGTVRF LRGAVKACRS GVRRSHLISY QEDGALLQEL FSRDGIGTQI VMESAEQIRR 

       310        320        330        340        350        360 
ATINDIGGIL ELIRPLEQQG ILVRRSREQL EMEIDKFTII QRDNLTIACA ALYPFPEEKI 

       370        380        390        400        410        420 
GEMACVAVHP DYRSSSRGEV LLERVAAQAR QIGLSKLFVL TTRSIHWFQE RGFTPVDIDS 

       430        440 
LPESKKEMYN YQRRSKVLMA DLG

« Hide

References

[1]"Complete sequence of chromosome of Enterobacter sp. 638."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Detter J.C., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Kim E., Taghavi S., Newman L., Vangronsveld J., van der Lelie D., Richardson P.
Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 638.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000653 Genomic DNA. Translation: ABP61925.1.
RefSeqYP_001177976.1. NC_009436.1.

3D structure databases

ProteinModelPortalA4WDZ5.
ModBaseSearch...

Protein-protein interaction databases

STRING399742.Ent638_3261.

Proteomic databases

PRIDEA4WDZ5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABP61925; ABP61925; Ent638_3261.
GeneID5112090.
KEGGent:Ent638_3261.
PATRIC20416241. VBIEntSp101211_3420.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0548.
HOGENOMHOG000262225.
KOK14682.
OMAPTGQAFN.
ProtClustDBPRK05279.

Enzyme and pathway databases

BioCycESP399742:GJ0E-3338-MONOMER.
UniPathwayUPA00068; UER00106.

Family and domain databases

Gene3D3.40.1160.10. 1 hit.
3.40.630.30. 1 hit.
HAMAPMF_01105. N-acetyl_glu_synth.
InterProIPR016181. Acyl_CoA_acyltransferase.
IPR001048. Asp/Glu/Uridylate_kinase.
IPR000182. GNAT_dom.
IPR010167. NH2A_AcTrfase_ArgA.
[Graphical view]
PfamPF00696. AA_kinase. 1 hit.
PF00583. Acetyltransf_1. 1 hit.
[Graphical view]
PIRSFPIRSF000423. ArgA. 1 hit.
SUPFAMSSF53633. Aa_kinase. 1 hit.
SSF55729. Acyl_CoA_acyltransferase. 1 hit.
TIGRFAMsTIGR01890. N-Ac-Glu-synth. 1 hit.
PROSITEPS51186. GNAT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameARGA_ENT38
AccessionPrimary (citable) accession number: A4WDZ5
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 29, 2007
Last modified: May 1, 2013
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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