Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

1,4-dihydroxy-2-naphthoyl-CoA synthase

Gene

menB

Organism
Enterobacter sp. (strain 638)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA).UniRule annotation

Catalytic activityi

4-(2-carboxyphenyl)-4-oxobutanoyl-CoA = 1,4-dihydroxy-2-naphthoyl-CoA + H2O.UniRule annotation

Cofactori

hydrogencarbonateUniRule annotation

Pathwayi: 1,4-dihydroxy-2-naphthoate biosynthesis

This protein is involved in step 6 of the subpathway that synthesizes 1,4-dihydroxy-2-naphthoate from chorismate.UniRule annotation
Proteins known to be involved in the 7 steps of the subpathway in this organism are:
  1. Isochorismate synthase MenF (menF)
  2. 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase (menD)
  3. 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase (menH)
  4. o-succinylbenzoate synthase (menC)
  5. no protein annotated in this organism
  6. 1,4-dihydroxy-2-naphthoyl-CoA synthase (menB)
  7. 1,4-dihydroxy-2-naphthoyl-CoA hydrolase (menI)
This subpathway is part of the pathway 1,4-dihydroxy-2-naphthoate biosynthesis, which is itself part of Quinol/quinone metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 1,4-dihydroxy-2-naphthoate from chorismate, the pathway 1,4-dihydroxy-2-naphthoate biosynthesis and in Quinol/quinone metabolism.

Pathwayi: menaquinone biosynthesis

This protein is involved in the pathway menaquinone biosynthesis, which is part of Quinol/quinone metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway menaquinone biosynthesis and in Quinol/quinone metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei45SubstrateUniRule annotation1
Binding sitei97SubstrateUniRule annotation1
Sitei97Important for catalysisUniRule annotation1
Binding sitei155SubstrateUniRule annotation1
Binding sitei161SubstrateUniRule annotation1
Binding sitei258Substrate; shared with neighboring subunitUniRule annotation1
Sitei258Important for catalysisUniRule annotation1
Binding sitei273Substrate; shared with neighboring subunitUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyaseUniRule annotationImported
Biological processMenaquinone biosynthesisUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00079.
UPA01057; UER00167.

Names & Taxonomyi

Protein namesi
Recommended name:
1,4-dihydroxy-2-naphthoyl-CoA synthaseUniRule annotation (EC:4.1.3.36UniRule annotation)
Short name:
DHNA-CoA synthaseUniRule annotation
Gene namesi
Name:menBUniRule annotation
Ordered Locus Names:Ent638_2812Imported
OrganismiEnterobacter sp. (strain 638)Imported
Taxonomic identifieri399742 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEnterobacter
Proteomesi
  • UP000000230 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi399742.Ent638_2812.

Structurei

3D structure databases

ProteinModelPortaliA4WCP7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni84 – 88Substrate bindingUniRule annotation5
Regioni129 – 133Substrate bindingUniRule annotation5
Regioni154 – 156Hydrogencarbonate bindingUniRule annotation3

Sequence similaritiesi

Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108IPT. Bacteria.
COG0447. LUCA.
HOGENOMiHOG000027942.
KOiK01661.
OMAiIFKQTDA.

Family and domain databases

Gene3Di1.10.12.10. 1 hit.
HAMAPiMF_01934. MenB. 1 hit.
InterProiView protein in InterPro
IPR029045. ClpP/crotonase-like_dom.
IPR014748. Crontonase_C.
IPR001753. Crotonase_core_superfam.
IPR010198. DHNA-CoA_synthase_MenB.
IPR018376. Enoyl-CoA_hyd/isom_CS.
PANTHERiPTHR43113. PTHR43113. 1 hit.
PfamiView protein in Pfam
PF00378. ECH_1. 1 hit.
SUPFAMiSSF52096. SSF52096. 1 hit.
TIGRFAMsiTIGR01929. menB. 1 hit.
PROSITEiView protein in PROSITE
PS00166. ENOYL_COA_HYDRATASE. 1 hit.

Sequencei

Sequence statusi: Complete.

A4WCP7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIYPDEQMLY APVEWQDCSE GYTDIRYHKS ADGIAKITIN RPQVRNAFRP
60 70 80 90 100
LTVKEMIQAM ADARYDDNIG VIVLTGEGDK AFCAGGDQKV RGDYGGYQDD
110 120 130 140 150
SGTHHLNVLD FQRQIRTCPK PVVAMVAGFS IGGGHVLHMM CDLTIAAENA
160 170 180 190 200
VFGQTGPKVG SFDGGWGASY MARIVGQKKA REIWFLCRQY NAQEALDMGL
210 220 230 240 250
VNTVVPIADL EKETVRWCRE MLQNSPMALR CLKAALNADC DGQAGLQELA
260 270 280
GNATMLFYMT EEGQEGRNAF NEKRQPDFSK YKRNP
Length:285
Mass (Da):31,696
Last modified:May 29, 2007 - v1
Checksum:iF11BC9FB557389C4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000653 Genomic DNA. Translation: ABP61477.1.
RefSeqiWP_015959810.1. NC_009436.1.

Genome annotation databases

EnsemblBacteriaiABP61477; ABP61477; Ent638_2812.
GeneIDi32444389.
KEGGient:Ent638_2812.

Similar proteinsi

Entry informationi

Entry nameiA4WCP7_ENT38
AccessioniPrimary (citable) accession number: A4WCP7
Entry historyiIntegrated into UniProtKB/TrEMBL: May 29, 2007
Last sequence update: May 29, 2007
Last modified: September 27, 2017
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteomeImported