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Protein

o-succinylbenzoate synthase

Gene

menC

Organism
Enterobacter sp. (strain 638)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB).UniRule annotation

Catalytic activityi

(1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate = 2-succinylbenzoate + H2O.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Pathwayi: 1,4-dihydroxy-2-naphthoate biosynthesis

This protein is involved in step 4 of the subpathway that synthesizes 1,4-dihydroxy-2-naphthoate from chorismate.UniRule annotation
Proteins known to be involved in the 7 steps of the subpathway in this organism are:
  1. Isochorismate synthase MenF (menF)
  2. 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase (menD)
  3. 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase (menH)
  4. o-succinylbenzoate synthase (menC)
  5. no protein annotated in this organism
  6. 1,4-dihydroxy-2-naphthoyl-CoA synthase (menB)
  7. 1,4-dihydroxy-2-naphthoyl-CoA hydrolase (menI)
This subpathway is part of the pathway 1,4-dihydroxy-2-naphthoate biosynthesis, which is itself part of Quinol/quinone metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 1,4-dihydroxy-2-naphthoate from chorismate, the pathway 1,4-dihydroxy-2-naphthoate biosynthesis and in Quinol/quinone metabolism.

Pathwayi: menaquinone biosynthesis

This protein is involved in the pathway menaquinone biosynthesis, which is part of Quinol/quinone metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway menaquinone biosynthesis and in Quinol/quinone metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei134Proton donorUniRule annotation1
Metal bindingi162MagnesiumUniRule annotation1
Metal bindingi191MagnesiumUniRule annotation1
Metal bindingi214MagnesiumUniRule annotation1
Active sitei236Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processMenaquinone biosynthesis
LigandMagnesium, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00079.
UPA01057; UER00165.

Names & Taxonomyi

Protein namesi
Recommended name:
o-succinylbenzoate synthaseUniRule annotation (EC:4.2.1.113UniRule annotation)
Short name:
OSB synthaseUniRule annotation
Short name:
OSBSUniRule annotation
Alternative name(s):
4-(2'-carboxyphenyl)-4-oxybutyric acid synthaseUniRule annotation
o-succinylbenzoic acid synthaseUniRule annotation
Gene namesi
Name:menCUniRule annotation
Ordered Locus Names:Ent638_2811
OrganismiEnterobacter sp. (strain 638)
Taxonomic identifieri399742 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEnterobacter
Proteomesi
  • UP000000230 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000603781 – 321o-succinylbenzoate synthaseAdd BLAST321

Interactioni

Protein-protein interaction databases

STRINGi399742.Ent638_2811.

Structurei

3D structure databases

ProteinModelPortaliA4WCP6.
SMRiA4WCP6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the mandelate racemase/muconate lactonizing enzyme family. MenC type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DNI. Bacteria.
COG1441. LUCA.
HOGENOMiHOG000271247.
KOiK02549.
OMAiYEANRDG.

Family and domain databases

Gene3Di3.20.20.120. 1 hit.
3.30.390.10. 1 hit.
HAMAPiMF_00470. MenC_1. 1 hit.
InterProiView protein in InterPro
IPR029065. Enolase_C-like.
IPR029017. Enolase_N-like.
IPR013342. Mandelate_racemase_C.
IPR010196. OSB_synthase_MenC1.
PfamiView protein in Pfam
PF13378. MR_MLE_C. 1 hit.
SMARTiView protein in SMART
SM00922. MR_MLE. 1 hit.
SUPFAMiSSF51604. SSF51604. 1 hit.
SSF54826. SSF54826. 1 hit.

Sequencei

Sequence statusi: Complete.

A4WCP6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRGAQVYRWQ IPMDAGVVLR DRRLKTRDGL FVHLQQDDRQ GWGEISPLPG
60 70 80 90 100
FSLESLAEAE AALLAWVNAW RIGESPALPA IPSAAFGISC ALAELDGTLP
110 120 130 140 150
EAADYRAAPL CSGDPDELFE SLAAMPGEKI AKVKVGLYEA VRDGMVVNLL
160 170 180 190 200
LEAIPDLRLR LDANRAWTPL KAQQFAKYVN PDYRDRIAFL EEPCKSRDDS
210 220 230 240 250
RAFAQETGIA IAWDESLREA GFEFVAEPGV TALVIKPTLT GSLDKVREQV
260 270 280 290 300
AAAHALGLTA VISSSIESSL GLTQLARIAA WLTPQTIPGL DTLNLMQSQL
310 320
VRRWPGNPLP YLDIEALEPL L
Length:321
Mass (Da):35,079
Last modified:May 29, 2007 - v1
Checksum:i96EDE5AC8A9DF148
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000653 Genomic DNA. Translation: ABP61476.1.
RefSeqiWP_015959809.1. NC_009436.1.

Genome annotation databases

EnsemblBacteriaiABP61476; ABP61476; Ent638_2811.
GeneIDi32441687.
KEGGient:Ent638_2811.

Similar proteinsi

Entry informationi

Entry nameiMENC_ENT38
AccessioniPrimary (citable) accession number: A4WCP6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 29, 2007
Last modified: July 5, 2017
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families