SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

A4WBR1

- OTSA_ENT38

UniProt

A4WBR1 - OTSA_ENT38

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Alpha,alpha-trehalose-phosphate synthase [UDP-forming]

Gene
otsA, Ent638_2472
Organism
Enterobacter sp. (strain 638)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the transfer of glucose from UDP-glucose to glucose-6-phosphate to form alpha,alpha-1,1 trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor By similarity.

Catalytic activityi

UDP-glucose + D-glucose 6-phosphate = UDP + alpha,alpha-trehalose 6-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei10 – 101Glucose-6-phosphate By similarity
Binding sitei77 – 771Glucose-6-phosphate By similarity
Sitei86 – 861Involved in alpha anomer selectivity By similarity
Binding sitei131 – 1311Glucose-6-phosphate By similarity
Sitei156 – 1561Involved in alpha anomer selectivity By similarity
Binding sitei263 – 2631UDP-glucose By similarity
Binding sitei268 – 2681UDP-glucose By similarity
Binding sitei301 – 3011Glucose-6-phosphate By similarity
Binding sitei340 – 3401UDP-glucose; via amide nitrogen and carbonyl oxygen By similarity

GO - Molecular functioni

  1. alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity Source: UniProtKB-EC

GO - Biological processi

  1. trehalose biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BioCyciESP399742:GJ0E-2520-MONOMER.
RETL1328306-WGS:GSTH-488-MONOMER.
UniPathwayiUPA00299.

Protein family/group databases

CAZyiGT20. Glycosyltransferase Family 20.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha,alpha-trehalose-phosphate synthase [UDP-forming] (EC:2.4.1.15)
Alternative name(s):
Osmoregulatory trehalose synthesis protein A
Trehalose-6-phosphate synthase
UDP-glucose-glucosephosphate glucosyltransferase
Gene namesi
Name:otsA
Ordered Locus Names:Ent638_2472
OrganismiEnterobacter sp. (strain 638)
Taxonomic identifieri399742 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEnterobacter
ProteomesiUP000000230: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 474474Alpha,alpha-trehalose-phosphate synthase [UDP-forming]PRO_0000348892Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.

Protein-protein interaction databases

STRINGi399742.Ent638_2472.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni22 – 232UDP-glucose binding By similarity
Regioni366 – 3705UDP-glucose binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0380.
HOGENOMiHOG000191478.
KOiK00697.
OMAiWGESFVK.
OrthoDBiEOG6CCH1M.

Family and domain databases

InterProiIPR001830. Glyco_trans_20.
IPR012766. Trehalose_OtsA.
[Graphical view]
PfamiPF00982. Glyco_transf_20. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02400. trehalose_OtsA. 1 hit.

Sequencei

Sequence statusi: Complete.

A4WBR1-1 [UniParc]FASTAAdd to Basket

« Hide

MGRLVVVSNR IAPPDDKKSS AGGLAVGILG ALKTAGGLWF GWSGEVGNED    50
KPLQKVTRGN ITWASFNLSE QDHEEYYSQF SNAVLWPAFH YRLDLVKFQR 100
DSWEGYTRVN ALLADKLLPL IEEDDILWIH DYHLLPFASE LRKRGVNNRI 150
GFFLHIPFPT PEIFTAIPPH EELLEGLCDY DLLGFQTEND RQAFLESVAG 200
KTRLTTHNGK SHQAWGKTFD TEVYPIGIEP DEIAADASGP LPPKLAQLKN 250
ELKNVKNIFS VERLDYSKGL PERFQAYERL LEKYPQHHGK IRYTQIAPTS 300
RGEVQAYQDI RHQLETEAGR INGRYGQLGW TPLYYLNQHF ERKVLMKVFR 350
YAEVGLVTPL RDGMNLVAKE YVAAQDPKDP GVLVLSQFAG AANELTSALL 400
VNPYDSDDVA NALDRALKMP LTERISRHAE MMKVIRENDI NHWQETFIRD 450
LKRTTPRSVE SNLQKKIATF PKLA 474
Length:474
Mass (Da):53,911
Last modified:May 29, 2007 - v1
Checksum:i58A0FA8BED879316
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000653 Genomic DNA. Translation: ABP61141.1.
RefSeqiWP_015959474.1. NC_009436.1.
YP_001177192.1. NC_009436.1.

Genome annotation databases

EnsemblBacteriaiABP61141; ABP61141; Ent638_2472.
GeneIDi5111632.
KEGGient:Ent638_2472.
PATRICi20414581. VBIEntSp101211_2618.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000653 Genomic DNA. Translation: ABP61141.1 .
RefSeqi WP_015959474.1. NC_009436.1.
YP_001177192.1. NC_009436.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 399742.Ent638_2472.

Protein family/group databases

CAZyi GT20. Glycosyltransferase Family 20.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABP61141 ; ABP61141 ; Ent638_2472 .
GeneIDi 5111632.
KEGGi ent:Ent638_2472.
PATRICi 20414581. VBIEntSp101211_2618.

Phylogenomic databases

eggNOGi COG0380.
HOGENOMi HOG000191478.
KOi K00697.
OMAi WGESFVK.
OrthoDBi EOG6CCH1M.

Enzyme and pathway databases

UniPathwayi UPA00299 .
BioCyci ESP399742:GJ0E-2520-MONOMER.
RETL1328306-WGS:GSTH-488-MONOMER.

Family and domain databases

InterProi IPR001830. Glyco_trans_20.
IPR012766. Trehalose_OtsA.
[Graphical view ]
Pfami PF00982. Glyco_transf_20. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR02400. trehalose_OtsA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the plant growth promoting endophytic bacterium Enterobacter sp. 638."
    Taghavi S., van der Lelie D., Hoffman A., Zhang Y.B., Walla M.D., Vangronsveld J., Newman L., Monchy S.
    PLoS Genet. 6:E1000943-E1000943(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 638.

Entry informationi

Entry nameiOTSA_ENT38
AccessioniPrimary (citable) accession number: A4WBR1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: May 29, 2007
Last modified: September 3, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi