Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

A4WAM1 (ARNT_ENT38) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferase

EC=2.4.2.43
Alternative name(s):
4-amino-4-deoxy-L-arabinose lipid A transferase
Lipid IV(A) 4-amino-4-deoxy-L-arabinosyltransferase
Undecaprenyl phosphate-alpha-L-Ara4N transferase
Gene names
Name:arnT
Ordered Locus Names:Ent638_2075
OrganismEnterobacter sp. (strain 638) [Complete proteome] [HAMAP]
Taxonomic identifier399742 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEnterobacter

Protein attributes

Sequence length553 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides By similarity. HAMAP-Rule MF_01165

Catalytic activity

4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + lipid IV(A) = lipid II(A) + di-trans,octa-cis-undecaprenyl phosphate. HAMAP-Rule MF_01165

Pathway

Lipopolysaccharide metabolism; 4-amino-4-deoxy-beta-L-arabinose-lipid A biosynthesis. HAMAP-Rule MF_01165

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01165.

Sequence similarities

Belongs to the glycosyltransferase 83 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 553553Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferase HAMAP-Rule MF_01165
PRO_1000065665

Regions

Transmembrane8 – 2821Helical; Potential
Transmembrane83 – 10321Helical; Potential
Transmembrane111 – 13121Helical; Potential
Transmembrane132 – 15221Helical; Potential
Transmembrane176 – 19621Helical; Potential
Transmembrane204 – 22421Helical; Potential
Transmembrane255 – 27521Helical; Potential
Transmembrane288 – 30821Helical; Potential
Transmembrane317 – 33721Helical; Potential
Transmembrane350 – 37021Helical; Potential
Transmembrane380 – 40021Helical; Potential
Transmembrane407 – 42721Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
A4WAM1 [UniParc].

Last modified May 29, 2007. Version 1.
Checksum: 7DE7980845DCE26C

FASTA55361,876
        10         20         30         40         50         60 
MKSAQYSLVL LLGFTLLYLL PLEFRALWQP DETRYAEISR EMLSAGNWIV PHFLDVRYFE 

        70         80         90        100        110        120 
KPVAGYWINN LSQMIFGHNN FSVRFGAVFS TTLSALMVAW LAFRLWRDKT VAVLSGVIFL 

       130        140        150        160        170        180 
TCLLVYGVGT YAVLDPMITL WLVAAMCSFW LGANAQTRAG KAGGYILLGL ACGMGVMTKG 

       190        200        210        220        230        240 
FLALAVPVLG VLPWVIAQKR WKEVLLFGPL AIISATLITL PWALAIAKAE PTFWHYFFWV 

       250        260        270        280        290        300 
EHIQRFAEND AQHKAPFWYY IPFLIAGCLP WVALLPGALK RSWNERHIES GTLYLLGWVV 

       310        320        330        340        350        360 
MPLLFFSIAK GKLPTYILPC FAPLAILLAR HATQLVATPR TLKVNGWINT VFGAVCALIV 

       370        380        390        400        410        420 
LLVLAPWGIA KHPIYASHEV LKVIQASIAF LVWALVGYLT TRNNARLWQW AALCPLGIAL 

       430        440        450        460        470        480 
LVGGMIPDKV VYSKHPQAFV DLVRPELESS RYILADSVGV GAGIAWEMKR SDITLYAKPG 

       490        500        510        520        530        540 
ELDYGLTTFA DAKDNFVSRD DFASWLALHR KEGNVSLVKL LSKDSVLEDS DVPAPDKVYH 

       550 
KGRFLLFFYE KTP 

« Hide

References

[1]"Genome sequence of the plant growth promoting endophytic bacterium Enterobacter sp. 638."
Taghavi S., van der Lelie D., Hoffman A., Zhang Y.B., Walla M.D., Vangronsveld J., Newman L., Monchy S.
PLoS Genet. 6:E1000943-E1000943(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 638.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000653 Genomic DNA. Translation: ABP60751.1.
RefSeqYP_001176802.1. NC_009436.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING399742.Ent638_2075.

Protein family/group databases

CAZyGT83. Glycosyltransferase Family 83.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABP60751; ABP60751; Ent638_2075.
GeneID5112196.
KEGGent:Ent638_2075.
PATRIC20413793. VBIEntSp101211_2226.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1807.
HOGENOMHOG000273002.
KOK07264.
OMAYLATEYR.
OrthoDBEOG6NKQWN.

Enzyme and pathway databases

BioCycESP399742:GJ0E-2121-MONOMER.
UniPathwayUPA00037.

Family and domain databases

HAMAPMF_01165. ArnT_transfer.
InterProIPR022839. ArnT_tfrase.
IPR003342. Glyco_trans_39.
[Graphical view]
PfamPF02366. PMT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameARNT_ENT38
AccessionPrimary (citable) accession number: A4WAM1
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 29, 2007
Last modified: May 14, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways