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Protein

Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferase

Gene

arnT

Organism
Enterobacter sp. (strain 638)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.UniRule annotation

Catalytic activityi

4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + lipid IV(A) = lipid II(A) + di-trans,octa-cis-undecaprenyl phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. mannosyltransferase activity Source: InterPro
  2. transferase activity, transferring pentosyl groups Source: InterPro

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-HAMAP
  2. lipopolysaccharide biosynthetic process Source: UniProtKB-KW
  3. protein O-linked glycosylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism, Lipopolysaccharide biosynthesis

Enzyme and pathway databases

BioCyciESP399742:GJ0E-2121-MONOMER.
UniPathwayiUPA00037.

Protein family/group databases

CAZyiGT83. Glycosyltransferase Family 83.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferaseUniRule annotation (EC:2.4.2.43UniRule annotation)
Alternative name(s):
4-amino-4-deoxy-L-arabinose lipid A transferaseUniRule annotation
Lipid IV(A) 4-amino-4-deoxy-L-arabinosyltransferaseUniRule annotation
Undecaprenyl phosphate-alpha-L-Ara4N transferaseUniRule annotation
Gene namesi
Name:arnTUniRule annotation
Ordered Locus Names:Ent638_2075
OrganismiEnterobacter sp. (strain 638)
Taxonomic identifieri399742 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEnterobacter
ProteomesiUP000000230: Chromosome

Subcellular locationi

Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei8 – 2821HelicalUniRule annotationAdd
BLAST
Transmembranei83 – 10321HelicalUniRule annotationAdd
BLAST
Transmembranei111 – 13121HelicalUniRule annotationAdd
BLAST
Transmembranei132 – 15221HelicalUniRule annotationAdd
BLAST
Transmembranei176 – 19621HelicalUniRule annotationAdd
BLAST
Transmembranei204 – 22421HelicalUniRule annotationAdd
BLAST
Transmembranei255 – 27521HelicalUniRule annotationAdd
BLAST
Transmembranei288 – 30821HelicalUniRule annotationAdd
BLAST
Transmembranei317 – 33721HelicalUniRule annotationAdd
BLAST
Transmembranei350 – 37021HelicalUniRule annotationAdd
BLAST
Transmembranei380 – 40021HelicalUniRule annotationAdd
BLAST
Transmembranei407 – 42721HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 553553Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferasePRO_1000065665Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi399742.Ent638_2075.

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 83 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1807.
HOGENOMiHOG000273002.
KOiK07264.
OMAiWLAAAMC.
OrthoDBiEOG6NKQWN.

Family and domain databases

HAMAPiMF_01165. ArnT_transfer.
InterProiIPR022839. ArnT_tfrase.
IPR003342. Glyco_trans_39.
[Graphical view]
PfamiPF02366. PMT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4WAM1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKSAQYSLVL LLGFTLLYLL PLEFRALWQP DETRYAEISR EMLSAGNWIV
60 70 80 90 100
PHFLDVRYFE KPVAGYWINN LSQMIFGHNN FSVRFGAVFS TTLSALMVAW
110 120 130 140 150
LAFRLWRDKT VAVLSGVIFL TCLLVYGVGT YAVLDPMITL WLVAAMCSFW
160 170 180 190 200
LGANAQTRAG KAGGYILLGL ACGMGVMTKG FLALAVPVLG VLPWVIAQKR
210 220 230 240 250
WKEVLLFGPL AIISATLITL PWALAIAKAE PTFWHYFFWV EHIQRFAEND
260 270 280 290 300
AQHKAPFWYY IPFLIAGCLP WVALLPGALK RSWNERHIES GTLYLLGWVV
310 320 330 340 350
MPLLFFSIAK GKLPTYILPC FAPLAILLAR HATQLVATPR TLKVNGWINT
360 370 380 390 400
VFGAVCALIV LLVLAPWGIA KHPIYASHEV LKVIQASIAF LVWALVGYLT
410 420 430 440 450
TRNNARLWQW AALCPLGIAL LVGGMIPDKV VYSKHPQAFV DLVRPELESS
460 470 480 490 500
RYILADSVGV GAGIAWEMKR SDITLYAKPG ELDYGLTTFA DAKDNFVSRD
510 520 530 540 550
DFASWLALHR KEGNVSLVKL LSKDSVLEDS DVPAPDKVYH KGRFLLFFYE

KTP
Length:553
Mass (Da):61,876
Last modified:May 29, 2007 - v1
Checksum:i7DE7980845DCE26C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000653 Genomic DNA. Translation: ABP60751.1.
RefSeqiWP_012017466.1. NC_009436.1.
YP_001176802.1. NC_009436.1.

Genome annotation databases

EnsemblBacteriaiABP60751; ABP60751; Ent638_2075.
GeneIDi5112196.
KEGGient:Ent638_2075.
PATRICi20413793. VBIEntSp101211_2226.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000653 Genomic DNA. Translation: ABP60751.1.
RefSeqiWP_012017466.1. NC_009436.1.
YP_001176802.1. NC_009436.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi399742.Ent638_2075.

Protein family/group databases

CAZyiGT83. Glycosyltransferase Family 83.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABP60751; ABP60751; Ent638_2075.
GeneIDi5112196.
KEGGient:Ent638_2075.
PATRICi20413793. VBIEntSp101211_2226.

Phylogenomic databases

eggNOGiCOG1807.
HOGENOMiHOG000273002.
KOiK07264.
OMAiWLAAAMC.
OrthoDBiEOG6NKQWN.

Enzyme and pathway databases

UniPathwayiUPA00037.
BioCyciESP399742:GJ0E-2121-MONOMER.

Family and domain databases

HAMAPiMF_01165. ArnT_transfer.
InterProiIPR022839. ArnT_tfrase.
IPR003342. Glyco_trans_39.
[Graphical view]
PfamiPF02366. PMT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the plant growth promoting endophytic bacterium Enterobacter sp. 638."
    Taghavi S., van der Lelie D., Hoffman A., Zhang Y.B., Walla M.D., Vangronsveld J., Newman L., Monchy S.
    PLoS Genet. 6:E1000943-E1000943(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 638.

Entry informationi

Entry nameiARNT_ENT38
AccessioniPrimary (citable) accession number: A4WAM1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 29, 2007
Last modified: January 7, 2015
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.