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A4WAM1

- ARNT_ENT38

UniProt

A4WAM1 - ARNT_ENT38

Protein

Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferase

Gene

arnT

Organism
Enterobacter sp. (strain 638)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (29 May 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.UniRule annotation

    Catalytic activityi

    4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + lipid IV(A) = lipid II(A) + di-trans,octa-cis-undecaprenyl phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. mannosyltransferase activity Source: InterPro
    2. transferase activity, transferring pentosyl groups Source: InterPro

    GO - Biological processi

    1. lipid A biosynthetic process Source: UniProtKB-HAMAP
    2. lipopolysaccharide biosynthetic process Source: UniProtKB-KW
    3. protein O-linked glycosylation Source: InterPro

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism, Lipopolysaccharide biosynthesis

    Enzyme and pathway databases

    BioCyciESP399742:GJ0E-2121-MONOMER.
    UniPathwayiUPA00037.

    Protein family/group databases

    CAZyiGT83. Glycosyltransferase Family 83.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferaseUniRule annotation (EC:2.4.2.43UniRule annotation)
    Alternative name(s):
    4-amino-4-deoxy-L-arabinose lipid A transferaseUniRule annotation
    Lipid IV(A) 4-amino-4-deoxy-L-arabinosyltransferaseUniRule annotation
    Undecaprenyl phosphate-alpha-L-Ara4N transferaseUniRule annotation
    Gene namesi
    Name:arnTUniRule annotation
    Ordered Locus Names:Ent638_2075
    OrganismiEnterobacter sp. (strain 638)
    Taxonomic identifieri399742 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEnterobacter
    ProteomesiUP000000230: Chromosome

    Subcellular locationi

    Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 553553Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferasePRO_1000065665Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi399742.Ent638_2075.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei8 – 2821HelicalUniRule annotationAdd
    BLAST
    Transmembranei83 – 10321HelicalUniRule annotationAdd
    BLAST
    Transmembranei111 – 13121HelicalUniRule annotationAdd
    BLAST
    Transmembranei132 – 15221HelicalUniRule annotationAdd
    BLAST
    Transmembranei176 – 19621HelicalUniRule annotationAdd
    BLAST
    Transmembranei204 – 22421HelicalUniRule annotationAdd
    BLAST
    Transmembranei255 – 27521HelicalUniRule annotationAdd
    BLAST
    Transmembranei288 – 30821HelicalUniRule annotationAdd
    BLAST
    Transmembranei317 – 33721HelicalUniRule annotationAdd
    BLAST
    Transmembranei350 – 37021HelicalUniRule annotationAdd
    BLAST
    Transmembranei380 – 40021HelicalUniRule annotationAdd
    BLAST
    Transmembranei407 – 42721HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyltransferase 83 family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1807.
    HOGENOMiHOG000273002.
    KOiK07264.
    OMAiYLATEYR.
    OrthoDBiEOG6NKQWN.

    Family and domain databases

    HAMAPiMF_01165. ArnT_transfer.
    InterProiIPR022839. ArnT_tfrase.
    IPR003342. Glyco_trans_39.
    [Graphical view]
    PfamiPF02366. PMT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A4WAM1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKSAQYSLVL LLGFTLLYLL PLEFRALWQP DETRYAEISR EMLSAGNWIV    50
    PHFLDVRYFE KPVAGYWINN LSQMIFGHNN FSVRFGAVFS TTLSALMVAW 100
    LAFRLWRDKT VAVLSGVIFL TCLLVYGVGT YAVLDPMITL WLVAAMCSFW 150
    LGANAQTRAG KAGGYILLGL ACGMGVMTKG FLALAVPVLG VLPWVIAQKR 200
    WKEVLLFGPL AIISATLITL PWALAIAKAE PTFWHYFFWV EHIQRFAEND 250
    AQHKAPFWYY IPFLIAGCLP WVALLPGALK RSWNERHIES GTLYLLGWVV 300
    MPLLFFSIAK GKLPTYILPC FAPLAILLAR HATQLVATPR TLKVNGWINT 350
    VFGAVCALIV LLVLAPWGIA KHPIYASHEV LKVIQASIAF LVWALVGYLT 400
    TRNNARLWQW AALCPLGIAL LVGGMIPDKV VYSKHPQAFV DLVRPELESS 450
    RYILADSVGV GAGIAWEMKR SDITLYAKPG ELDYGLTTFA DAKDNFVSRD 500
    DFASWLALHR KEGNVSLVKL LSKDSVLEDS DVPAPDKVYH KGRFLLFFYE 550
    KTP 553
    Length:553
    Mass (Da):61,876
    Last modified:May 29, 2007 - v1
    Checksum:i7DE7980845DCE26C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000653 Genomic DNA. Translation: ABP60751.1.
    RefSeqiWP_012017466.1. NC_009436.1.
    YP_001176802.1. NC_009436.1.

    Genome annotation databases

    EnsemblBacteriaiABP60751; ABP60751; Ent638_2075.
    GeneIDi5112196.
    KEGGient:Ent638_2075.
    PATRICi20413793. VBIEntSp101211_2226.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000653 Genomic DNA. Translation: ABP60751.1 .
    RefSeqi WP_012017466.1. NC_009436.1.
    YP_001176802.1. NC_009436.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 399742.Ent638_2075.

    Protein family/group databases

    CAZyi GT83. Glycosyltransferase Family 83.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABP60751 ; ABP60751 ; Ent638_2075 .
    GeneIDi 5112196.
    KEGGi ent:Ent638_2075.
    PATRICi 20413793. VBIEntSp101211_2226.

    Phylogenomic databases

    eggNOGi COG1807.
    HOGENOMi HOG000273002.
    KOi K07264.
    OMAi YLATEYR.
    OrthoDBi EOG6NKQWN.

    Enzyme and pathway databases

    UniPathwayi UPA00037 .
    BioCyci ESP399742:GJ0E-2121-MONOMER.

    Family and domain databases

    HAMAPi MF_01165. ArnT_transfer.
    InterProi IPR022839. ArnT_tfrase.
    IPR003342. Glyco_trans_39.
    [Graphical view ]
    Pfami PF02366. PMT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the plant growth promoting endophytic bacterium Enterobacter sp. 638."
      Taghavi S., van der Lelie D., Hoffman A., Zhang Y.B., Walla M.D., Vangronsveld J., Newman L., Monchy S.
      PLoS Genet. 6:E1000943-E1000943(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 638.

    Entry informationi

    Entry nameiARNT_ENT38
    AccessioniPrimary (citable) accession number: A4WAM1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: May 29, 2007
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3