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A4W9Z4

- FOLM_ENT38

UniProt

A4W9Z4 - FOLM_ENT38

Protein

Dihydrofolate reductase FolM

Gene

folM

Organism
Enterobacter sp. (strain 638)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (29 May 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the reduction of dihydrofolate to tetrahydrofolate.By similarity

    Catalytic activityi

    5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei152 – 1521Proton acceptorPROSITE-ProRule annotation

    GO - Molecular functioni

    1. dihydrofolate reductase activity Source: UniProtKB-EC

    GO - Biological processi

    1. one-carbon metabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    BioCyciESP399742:GJ0E-1892-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dihydrofolate reductase FolM (EC:1.5.1.3)
    Short name:
    DHFR
    Gene namesi
    Name:folM
    Ordered Locus Names:Ent638_1846
    OrganismiEnterobacter sp. (strain 638)
    Taxonomic identifieri399742 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEnterobacter
    ProteomesiUP000000230: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 240240Dihydrofolate reductase FolMPRO_0000339389Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi399742.Ent638_1846.

    Structurei

    3D structure databases

    ProteinModelPortaliA4W9Z4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1028.
    KOiK13938.
    OMAiMKIAPGE.
    OrthoDBiEOG6WDSG3.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    InterProiIPR002198. DH_sc/Rdtase_SDR.
    IPR002347. Glc/ribitol_DH.
    IPR016040. NAD(P)-bd_dom.
    IPR020904. Sc_DH/Rdtase_CS.
    [Graphical view]
    PfamiPF00106. adh_short. 1 hit.
    [Graphical view]
    PRINTSiPR00081. GDHRDH.
    PROSITEiPS00061. ADH_SHORT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A4W9Z4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGNAPQRPIL ITGGGRRIGL ALAHHFLTLR QPVIVSYRNE YPSIEGLRQA    50
    GATCIQADFS TDEGILRFAE TVKSNTRGLR AIIHNASAWQ AEKPGTPLSE 100
    TLACMMQIHV HAPYLLNHAL EELLRGHGHA AGDIIHFTDY VVERGSDKHI 150
    AYAASKAALD NMTRSFARKL APEVKVNAIA PSLILFNEED DAEYRQKALN 200
    KSLMKIVPGE KEVIDLIDYL LTSCYVTGRS FGVDGGRPLN 240
    Length:240
    Mass (Da):26,370
    Last modified:May 29, 2007 - v1
    Checksum:i4548F2A04F03AF87
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000653 Genomic DNA. Translation: ABP60524.1.
    RefSeqiWP_012017239.1. NC_009436.1.
    YP_001176575.1. NC_009436.1.

    Genome annotation databases

    EnsemblBacteriaiABP60524; ABP60524; Ent638_1846.
    GeneIDi5113369.
    KEGGient:Ent638_1846.
    PATRICi20413325. VBIEntSp101211_1992.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000653 Genomic DNA. Translation: ABP60524.1 .
    RefSeqi WP_012017239.1. NC_009436.1.
    YP_001176575.1. NC_009436.1.

    3D structure databases

    ProteinModelPortali A4W9Z4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 399742.Ent638_1846.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABP60524 ; ABP60524 ; Ent638_1846 .
    GeneIDi 5113369.
    KEGGi ent:Ent638_1846.
    PATRICi 20413325. VBIEntSp101211_1992.

    Phylogenomic databases

    eggNOGi COG1028.
    KOi K13938.
    OMAi MKIAPGE.
    OrthoDBi EOG6WDSG3.

    Enzyme and pathway databases

    BioCyci ESP399742:GJ0E-1892-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    InterProi IPR002198. DH_sc/Rdtase_SDR.
    IPR002347. Glc/ribitol_DH.
    IPR016040. NAD(P)-bd_dom.
    IPR020904. Sc_DH/Rdtase_CS.
    [Graphical view ]
    Pfami PF00106. adh_short. 1 hit.
    [Graphical view ]
    PRINTSi PR00081. GDHRDH.
    PROSITEi PS00061. ADH_SHORT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the plant growth promoting endophytic bacterium Enterobacter sp. 638."
      Taghavi S., van der Lelie D., Hoffman A., Zhang Y.B., Walla M.D., Vangronsveld J., Newman L., Monchy S.
      PLoS Genet. 6:E1000943-E1000943(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 638.

    Entry informationi

    Entry nameiFOLM_ENT38
    AccessioniPrimary (citable) accession number: A4W9Z4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 10, 2008
    Last sequence update: May 29, 2007
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3