Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

A4W9Z4

- FOLM_ENT38

UniProt

A4W9Z4 - FOLM_ENT38

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Dihydrofolate reductase FolM

Gene

folM

Organism
Enterobacter sp. (strain 638)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the reduction of dihydrofolate to tetrahydrofolate.By similarity

Catalytic activityi

5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei152 – 1521Proton acceptorPROSITE-ProRule annotation

GO - Molecular functioni

  1. dihydrofolate reductase activity Source: UniProtKB-EC

GO - Biological processi

  1. one-carbon metabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciESP399742:GJ0E-1892-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydrofolate reductase FolM (EC:1.5.1.3)
Short name:
DHFR
Gene namesi
Name:folM
Ordered Locus Names:Ent638_1846
OrganismiEnterobacter sp. (strain 638)
Taxonomic identifieri399742 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEnterobacter
ProteomesiUP000000230: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 240240Dihydrofolate reductase FolMPRO_0000339389Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi399742.Ent638_1846.

Structurei

3D structure databases

ProteinModelPortaliA4W9Z4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1028.
KOiK13938.
OMAiMKIAPGE.
OrthoDBiEOG6WDSG3.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4W9Z4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGNAPQRPIL ITGGGRRIGL ALAHHFLTLR QPVIVSYRNE YPSIEGLRQA
60 70 80 90 100
GATCIQADFS TDEGILRFAE TVKSNTRGLR AIIHNASAWQ AEKPGTPLSE
110 120 130 140 150
TLACMMQIHV HAPYLLNHAL EELLRGHGHA AGDIIHFTDY VVERGSDKHI
160 170 180 190 200
AYAASKAALD NMTRSFARKL APEVKVNAIA PSLILFNEED DAEYRQKALN
210 220 230 240
KSLMKIVPGE KEVIDLIDYL LTSCYVTGRS FGVDGGRPLN
Length:240
Mass (Da):26,370
Last modified:May 29, 2007 - v1
Checksum:i4548F2A04F03AF87
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000653 Genomic DNA. Translation: ABP60524.1.
RefSeqiWP_012017239.1. NC_009436.1.
YP_001176575.1. NC_009436.1.

Genome annotation databases

EnsemblBacteriaiABP60524; ABP60524; Ent638_1846.
GeneIDi5113369.
KEGGient:Ent638_1846.
PATRICi20413325. VBIEntSp101211_1992.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000653 Genomic DNA. Translation: ABP60524.1 .
RefSeqi WP_012017239.1. NC_009436.1.
YP_001176575.1. NC_009436.1.

3D structure databases

ProteinModelPortali A4W9Z4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 399742.Ent638_1846.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABP60524 ; ABP60524 ; Ent638_1846 .
GeneIDi 5113369.
KEGGi ent:Ent638_1846.
PATRICi 20413325. VBIEntSp101211_1992.

Phylogenomic databases

eggNOGi COG1028.
KOi K13938.
OMAi MKIAPGE.
OrthoDBi EOG6WDSG3.

Enzyme and pathway databases

BioCyci ESP399742:GJ0E-1892-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view ]
Pfami PF00106. adh_short. 1 hit.
[Graphical view ]
PRINTSi PR00081. GDHRDH.
PROSITEi PS00061. ADH_SHORT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the plant growth promoting endophytic bacterium Enterobacter sp. 638."
    Taghavi S., van der Lelie D., Hoffman A., Zhang Y.B., Walla M.D., Vangronsveld J., Newman L., Monchy S.
    PLoS Genet. 6:E1000943-E1000943(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 638.

Entry informationi

Entry nameiFOLM_ENT38
AccessioniPrimary (citable) accession number: A4W9Z4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: May 29, 2007
Last modified: October 1, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3