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A4W9X4 (ADD_ENT38) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Adenosine deaminase
EC=3.5.4.4
Alternative name(s):
Adenosine aminohydrolase
Gene names
Name:add
Ordered Locus Names:Ent638_1825
OrganismEnterobacter sp. (strain 638) [Complete proteome] [HAMAP]
Taxonomic identifier399742 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Enterobacter

Protein attributes

Sequence length332 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Adenosine + H2O = inosine + NH3. HAMAP MF_00540

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP MF_00540

Sequence similarities

Belongs to the adenosine and AMP deaminases family. Adenosine deaminase subfamily.

Ontologies

Keywords
   Biological processNucleotide metabolism
   LigandMetal-binding
Zinc
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processpurine ribonucleoside monophosphate biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Molecular functionadenosine deaminase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 332332Adenosine deaminase HAMAP MF_00540
PRO_1000061056

Sites

Active site2001Proton donor By similarity
Metal binding121Zinc; catalytic By similarity
Metal binding141Zinc; catalytic By similarity
Metal binding1971Zinc; catalytic By similarity
Metal binding2781Zinc; catalytic By similarity
Binding site141Substrate By similarity
Binding site161Substrate By similarity
Binding site1701Substrate; via amide nitrogen and carbonyl oxygen By similarity
Binding site2791Substrate By similarity
Site2211Important for catalytic activity By similarity

Sequences

Sequence LengthMass (Da)Tools
A4W9X4 [UniParc].

Last modified May 29, 2007. Version 1.
Checksum: B733A6B72CC70D53

FASTA33236,246
        10         20         30         40         50         60 
MIDTRLPLTD IHRHLDGNIR AQTILDLGRQ FNLSLPAATL ESLIPHVQVT ANEPDLVSFL 

        70         80         90        100        110        120 
SKLDWGVKVL ASLDACRRVA FENIEDAARN GLHYVELRFS PGYMAMTHNL PVEGVVEAVI 

       130        140        150        160        170        180 
EGVREGCKAF NVQARLIGIM SRTFGESACL QELEGLLAHR DHITAVDLAG DELGFPGSLF 

       190        200        210        220        230        240 
LSHFNRARDA GWHITVHAGE AAGPESIWQA IRELGAERIG HGVKAVEDRA LMDFLAEQRI 

       250        260        270        280        290        300 
GIESCLTSNI QTSTVASLVQ HPLKTFLEHG VLATLNTDDP AVQGVDIIHE YNVAAPQAGL 

       310        320        330 
SREQIRQAQI NGLEIAFLTP SEKQALRELV AG

« Hide

References

[1]"Complete sequence of chromosome of Enterobacter sp. 638."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Detter J.C., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Kim E., Taghavi S., Newman L., Vangronsveld J., van der Lelie D., Richardson P.
Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 638.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000653 Genomic DNA. Translation: ABP60504.1.
RefSeqYP_001176555.1. NC_009436.1.

3D structure databases

ProteinModelPortalA4W9X4.
ModBaseSearch...

Protein-protein interaction databases

STRINGA4W9X4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5113348.
GenomeReviewsGene locus Ent638_1825 in contig CP000653_GR.
KEGGent:Ent638_1825.
NMPDRfig|399742.4.peg.1796.
PATRIC20413285. VBIEntSp101211_1972.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1816.
HOGENOMHBG630382.
OMADIAYKEN.
PhylomeDBA4W9X4.
ProtClustDBPRK09358.

Enzyme and pathway databases

BioCycESP42895:ENT638_1825-MONOMER.

Family and domain databases

HAMAPMF_00540. A_deaminase.
[Tree]
InterProIPR001365. A/AMP_deaminase_dom.
IPR006330. A_deaminase.
[Graphical view]
KOK01488.
PfamPF00962. A_deaminase. 1 hit.
[Graphical view]
TIGRFAMsTIGR01430. Aden_deam. 1 hit.
PROSITEPS00485. A_DEAMINASE. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameADD_ENT38
AccessionPrimary (citable) accession number: A4W9X4
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 29, 2007
Last modified: January 25, 2012
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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