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A4W9T2

- MDTK_ENT38

UniProt

A4W9T2 - MDTK_ENT38

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Protein

Multidrug resistance protein MdtK

Gene
mdtK, Ent638_1783
Organism
Enterobacter sp. (strain 638)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Multidrug efflux pump that functions probably as a Na+/drug antiporter By similarity.UniRule annotation

GO - Molecular functioni

  1. antiporter activity Source: UniProtKB-HAMAP
  2. drug transmembrane transporter activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. sodium ion transport Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Biological processi

Antiport, Ion transport, Sodium transport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

BioCyciESP399742:GJ0E-1829-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug resistance protein MdtK
Alternative name(s):
Multidrug-efflux transporter
Gene namesi
Name:mdtK
Ordered Locus Names:Ent638_1783
OrganismiEnterobacter sp. (strain 638)
Taxonomic identifieri399742 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEnterobacter
ProteomesiUP000000230: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei11 – 3121Helical; Reviewed predictionAdd
BLAST
Transmembranei53 – 7321Helical; Reviewed predictionAdd
BLAST
Transmembranei93 – 11321Helical; Reviewed predictionAdd
BLAST
Transmembranei127 – 14721Helical; Reviewed predictionAdd
BLAST
Transmembranei160 – 18021Helical; Reviewed predictionAdd
BLAST
Transmembranei189 – 20921Helical; Reviewed predictionAdd
BLAST
Transmembranei243 – 26321Helical; Reviewed predictionAdd
BLAST
Transmembranei276 – 29621Helical; Reviewed predictionAdd
BLAST
Transmembranei314 – 33421Helical; Reviewed predictionAdd
BLAST
Transmembranei357 – 37721Helical; Reviewed predictionAdd
BLAST
Transmembranei387 – 40721Helical; Reviewed predictionAdd
BLAST
Transmembranei418 – 43821Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 457457Multidrug resistance protein MdtKUniRule annotationPRO_1000060797Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi399742.Ent638_1783.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0534.
HOGENOMiHOG000038538.
KOiK03327.
OMAiGGVGCGW.
OrthoDBiEOG6423C5.

Family and domain databases

HAMAPiMF_00400. MdtK.
InterProiIPR002528. MATE.
IPR022913. Multidrug-R_MdtK.
[Graphical view]
PfamiPF01554. MatE. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00797. matE. 1 hit.

Sequencei

Sequence statusi: Complete.

A4W9T2-1 [UniParc]FASTAAdd to Basket

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MQKYMLEARQ LLALAIPVII AQVAQTSMGF VDTVMAGGYS ATDMAAVAIG    50
TSIWLPAILF GHGLLLALTP VIAQLNGSGR RERIAHQVRQ GFWLAGFVSI 100
LIMVVLWNAG YIIRSMDNID PALADKAVGY LRALLWGAPG YLFFQVARNQ 150
CEGLAKTKPG MVMGFIGLLV NIPVNYIFIY GHFGMPELGG VGCGVATAAV 200
YWVMFFSMIS YVKRARSMRD IRNEQRFSKP DMDVLKRLAQ LGLPIALALF 250
FEVTLFAVVA LLVSPLGIVD VAGHQIALNF SSLMFVLPMS LAAAVTIRVG 300
YRLGQGSTLD AQTAARTGLG VGVCMAFCTA LFTVTLREQI ALLYNDNPEV 350
ITLASQLMLL AAIYQLSDSI QVIGSGILRG YKDTRSIFFI TFTAYWVLGL 400
PTGYILALTD LVVDRMGPAG FWMGFIIGLT SAAILMMLRM RFLQRQPSSV 450
ILQRAAR 457
Length:457
Mass (Da):49,778
Last modified:May 29, 2007 - v1
Checksum:i8B840778F77B424E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000653 Genomic DNA. Translation: ABP60462.1.
RefSeqiWP_012017177.1. NC_009436.1.
YP_001176513.1. NC_009436.1.

Genome annotation databases

EnsemblBacteriaiABP60462; ABP60462; Ent638_1783.
GeneIDi5113306.
KEGGient:Ent638_1783.
PATRICi20413197. VBIEntSp101211_1928.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000653 Genomic DNA. Translation: ABP60462.1 .
RefSeqi WP_012017177.1. NC_009436.1.
YP_001176513.1. NC_009436.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 399742.Ent638_1783.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABP60462 ; ABP60462 ; Ent638_1783 .
GeneIDi 5113306.
KEGGi ent:Ent638_1783.
PATRICi 20413197. VBIEntSp101211_1928.

Phylogenomic databases

eggNOGi COG0534.
HOGENOMi HOG000038538.
KOi K03327.
OMAi GGVGCGW.
OrthoDBi EOG6423C5.

Enzyme and pathway databases

BioCyci ESP399742:GJ0E-1829-MONOMER.

Family and domain databases

HAMAPi MF_00400. MdtK.
InterProi IPR002528. MATE.
IPR022913. Multidrug-R_MdtK.
[Graphical view ]
Pfami PF01554. MatE. 2 hits.
[Graphical view ]
TIGRFAMsi TIGR00797. matE. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the plant growth promoting endophytic bacterium Enterobacter sp. 638."
    Taghavi S., van der Lelie D., Hoffman A., Zhang Y.B., Walla M.D., Vangronsveld J., Newman L., Monchy S.
    PLoS Genet. 6:E1000943-E1000943(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 638.

Entry informationi

Entry nameiMDTK_ENT38
AccessioniPrimary (citable) accession number: A4W9T2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 29, 2007
Last modified: September 3, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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