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A4W9T2

- MDTK_ENT38

UniProt

A4W9T2 - MDTK_ENT38

Protein

Multidrug resistance protein MdtK

Gene

mdtK

Organism
Enterobacter sp. (strain 638)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (29 May 2007)
      Previous versions | rss
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    Functioni

    Multidrug efflux pump that functions probably as a Na+/drug antiporter.UniRule annotation

    GO - Molecular functioni

    1. antiporter activity Source: UniProtKB-HAMAP
    2. drug transmembrane transporter activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. sodium ion transport Source: UniProtKB-HAMAP

    Keywords - Biological processi

    Antiport, Ion transport, Sodium transport, Transport

    Keywords - Ligandi

    Sodium

    Enzyme and pathway databases

    BioCyciESP399742:GJ0E-1829-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Multidrug resistance protein MdtKUniRule annotation
    Alternative name(s):
    Multidrug-efflux transporterUniRule annotation
    Gene namesi
    Name:mdtKUniRule annotation
    Ordered Locus Names:Ent638_1783
    OrganismiEnterobacter sp. (strain 638)
    Taxonomic identifieri399742 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEnterobacter
    ProteomesiUP000000230: Chromosome

    Subcellular locationi

    Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 457457Multidrug resistance protein MdtKPRO_1000060797Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi399742.Ent638_1783.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei11 – 3121HelicalUniRule annotationAdd
    BLAST
    Transmembranei53 – 7321HelicalUniRule annotationAdd
    BLAST
    Transmembranei93 – 11321HelicalUniRule annotationAdd
    BLAST
    Transmembranei127 – 14721HelicalUniRule annotationAdd
    BLAST
    Transmembranei160 – 18021HelicalUniRule annotationAdd
    BLAST
    Transmembranei189 – 20921HelicalUniRule annotationAdd
    BLAST
    Transmembranei243 – 26321HelicalUniRule annotationAdd
    BLAST
    Transmembranei276 – 29621HelicalUniRule annotationAdd
    BLAST
    Transmembranei314 – 33421HelicalUniRule annotationAdd
    BLAST
    Transmembranei357 – 37721HelicalUniRule annotationAdd
    BLAST
    Transmembranei387 – 40721HelicalUniRule annotationAdd
    BLAST
    Transmembranei418 – 43821HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MdtK subfamily. [View classification]UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0534.
    HOGENOMiHOG000038538.
    KOiK03327.
    OMAiGGVGCGW.
    OrthoDBiEOG6423C5.

    Family and domain databases

    HAMAPiMF_00400. MdtK.
    InterProiIPR002528. MATE.
    IPR022913. Multidrug-R_MdtK.
    [Graphical view]
    PfamiPF01554. MatE. 2 hits.
    [Graphical view]
    TIGRFAMsiTIGR00797. matE. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A4W9T2-1 [UniParc]FASTAAdd to Basket

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    MQKYMLEARQ LLALAIPVII AQVAQTSMGF VDTVMAGGYS ATDMAAVAIG    50
    TSIWLPAILF GHGLLLALTP VIAQLNGSGR RERIAHQVRQ GFWLAGFVSI 100
    LIMVVLWNAG YIIRSMDNID PALADKAVGY LRALLWGAPG YLFFQVARNQ 150
    CEGLAKTKPG MVMGFIGLLV NIPVNYIFIY GHFGMPELGG VGCGVATAAV 200
    YWVMFFSMIS YVKRARSMRD IRNEQRFSKP DMDVLKRLAQ LGLPIALALF 250
    FEVTLFAVVA LLVSPLGIVD VAGHQIALNF SSLMFVLPMS LAAAVTIRVG 300
    YRLGQGSTLD AQTAARTGLG VGVCMAFCTA LFTVTLREQI ALLYNDNPEV 350
    ITLASQLMLL AAIYQLSDSI QVIGSGILRG YKDTRSIFFI TFTAYWVLGL 400
    PTGYILALTD LVVDRMGPAG FWMGFIIGLT SAAILMMLRM RFLQRQPSSV 450
    ILQRAAR 457
    Length:457
    Mass (Da):49,778
    Last modified:May 29, 2007 - v1
    Checksum:i8B840778F77B424E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000653 Genomic DNA. Translation: ABP60462.1.
    RefSeqiWP_012017177.1. NC_009436.1.
    YP_001176513.1. NC_009436.1.

    Genome annotation databases

    EnsemblBacteriaiABP60462; ABP60462; Ent638_1783.
    GeneIDi5113306.
    KEGGient:Ent638_1783.
    PATRICi20413197. VBIEntSp101211_1928.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000653 Genomic DNA. Translation: ABP60462.1 .
    RefSeqi WP_012017177.1. NC_009436.1.
    YP_001176513.1. NC_009436.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 399742.Ent638_1783.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABP60462 ; ABP60462 ; Ent638_1783 .
    GeneIDi 5113306.
    KEGGi ent:Ent638_1783.
    PATRICi 20413197. VBIEntSp101211_1928.

    Phylogenomic databases

    eggNOGi COG0534.
    HOGENOMi HOG000038538.
    KOi K03327.
    OMAi GGVGCGW.
    OrthoDBi EOG6423C5.

    Enzyme and pathway databases

    BioCyci ESP399742:GJ0E-1829-MONOMER.

    Family and domain databases

    HAMAPi MF_00400. MdtK.
    InterProi IPR002528. MATE.
    IPR022913. Multidrug-R_MdtK.
    [Graphical view ]
    Pfami PF01554. MatE. 2 hits.
    [Graphical view ]
    TIGRFAMsi TIGR00797. matE. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the plant growth promoting endophytic bacterium Enterobacter sp. 638."
      Taghavi S., van der Lelie D., Hoffman A., Zhang Y.B., Walla M.D., Vangronsveld J., Newman L., Monchy S.
      PLoS Genet. 6:E1000943-E1000943(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 638.

    Entry informationi

    Entry nameiMDTK_ENT38
    AccessioniPrimary (citable) accession number: A4W9T2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: May 29, 2007
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3