ID   ASTD_ENT38              Reviewed;         495 AA.
AC   A4W9J7;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   29-MAY-2007, sequence version 1.
DT   16-JUN-2009, entry version 19.
DE   RecName: Full=N-succinylglutamate 5-semialdehyde dehydrogenase;
DE            EC=1.2.1.71;
DE   AltName: Full=Succinylglutamic semialdehyde dehydrogenase;
DE            Short=SGSD;
GN   Name=astD; OrderedLocusNames=Ent638_1698;
OS   Enterobacter sp. (strain 638).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Enterobacter.
OX   NCBI_TaxID=399742;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T.,
RA   Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D.,
RA   Detter J.C., Han C., Tapia R., Gilna P., Schmutz J., Larimer F.,
RA   Land M., Hauser L., Kyrpides N., Kim E., Taghavi S., Newman L.,
RA   Vangronsveld J., van der Lelie D., Richardson P.;
RT   "Complete sequence of chromosome of Enterobacter sp. 638.";
RL   Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the NAD-dependent reduction of
CC       succinylglutamate semialdehyde into succinylglutamate (By
CC       similarity).
CC   -!- CATALYTIC ACTIVITY: N-succinyl-L-glutamate 5-semialdehyde + NAD(+)
CC       + H(2)O = N-succinyl-L-glutamate + NADH.
CC   -!- PATHWAY: Amino-acid degradation; L-arginine degradation via AST
CC       pathway; L-glutamate and succinate from L-arginine: step 4/5.
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family. AstD
CC       subfamily.
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DR   EMBL; CP000653; ABP60377.1; -; Genomic_DNA.
DR   RefSeq; YP_001176428.1; -.
DR   GeneID; 5112437; -.
DR   GenomeReviews; CP000653_GR; Ent638_1698.
DR   KEGG; ent:Ent638_1698; -.
DR   NMPDR; fig|399742.4.peg.1674; -.
DR   OMA; A4W9J7; KAYHART.
DR   GO; GO:0043824; F:succinylglutamate-semialdehyde dehydrogenas...; IEA:EC.
DR   GO; GO:0019544; P:arginine catabolic process to glutamate; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   HAMAP; MF_01174; -; 1.
DR   InterPro; IPR016160; Ald_DH_CS.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH.
DR   InterPro; IPR017649; SuccinylGlu_semiald_DH_AstD.
DR   Gene3D; G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.
DR   PANTHER; PTHR11699; Aldehyde_dehyd; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   TIGRFAMs; TIGR03240; arg_catab_astD; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   3: Inferred from homology;
KW   Arginine metabolism; Complete proteome; NAD; Oxidoreductase.
FT   CHAIN         1    495       N-succinylglutamate 5-semialdehyde
FT                                dehydrogenase.
FT                                /FTId=PRO_1000065756.
FT   NP_BIND     220    225       NAD (By similarity).
FT   ACT_SITE    243    243       By similarity.
FT   ACT_SITE    277    277       By similarity.
SQ   SEQUENCE   495 AA;  53142 MW;  E72D3DEEA16BF24A CRC64;
     MSLWINGDWV TGEGERRVKT NPVGNEALWQ GFDASPAQVE QACQAARKAF PAWAKLPFTA
     RQAIVEKFAT LLEANKAELT RVIARETGKP RWEATTEITA MINKITISVK AYHTRTGEQH
     TAMADGAATL RHRPHGVLAV FGPYNFPGHL PNGHIVPALL AGNTVIFKPS ELTPWSGEAV
     VKLWEQAGLP PGVLNLVQGG RETGQALSAL SDLDGLLFTG SAGTGYQLHR QLAGQPEKIL
     ALEMGGNNPL IVEDPEDIDA AVHLAIQSAF VTAGQRCTCA RRLLVKNGAQ GDAFLARLIE
     VTARLVPDAW DAEPQPFIGG LISEQAANNV IHAWREHVAR GAKTLLEPKL VQPGTSLLTP
     GIIDMSDARD IPDEEVFGPL LCVWRYDDFD SAIAMANNTR YGLSSGLISP DREKFDQLLI
     EARAGIVNWN KPLTGAASTA PFGGVGASGN HRASAWYAAD YCAWPMASLE TPALTLPEAL
     NPGLDFTQGN GHESA
//