Reviewed, UniProtKB/Swiss-Prot A4W9J7 (ASTD_ENT38)

Names and origin

Protein names

Recommended name:
    N-succinylglutamate 5-semialdehyde dehydrogenase
    EC=1.2.1.71
Alternative name(s):
    Succinylglutamic semialdehyde dehydrogenase
      Short name=SGSD

Gene names

Name:	astD
Ordered Locus Names:	Ent638_1698

Organism

Enterobacter sp. (strain 638) [Complete proteome] [HAMAP]

Taxonomic identifier

399742 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Enterobacter

Protein attributes

Sequence length	495 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate By similarity.
Catalytic activity	N-succinyl-L-glutamate 5-semialdehyde + NAD(+) + H(2)O = N-succinyl-L-glutamate + NADH.
Pathway	Amino-acid degradation; L-arginine degradation via AST pathway; L-glutamate and succinate from L-arginine: step 4/5.
Sequence similarities	Belongs to the aldehyde dehydrogenase family. AstD subfamily.

Ontologies

Keywords
Biological process	Arginine metabolism
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine catabolic process to glutamate Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	succinylglutamate-semialdehyde dehydrogenase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 495	495	N-succinylglutamate 5-semialdehyde dehydrogenase		PRO_1000065756
Regions
	Nucleotide binding	220 – 225	6	NAD By similarity
Sites
	Active site	243	1	By similarity
	Active site	277	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	A4W9J7-1 [UniParc]. Last modified May 29, 2007. Version 1. Checksum: E72D3DEEA16BF24A	FASTA	495	53,142
	10 20 30 40 50 60 MSLWINGDWV TGEGERRVKT NPVGNEALWQ GFDASPAQVE QACQAARKAF PAWAKLPFTA 70 80 90 100 110 120 RQAIVEKFAT LLEANKAELT RVIARETGKP RWEATTEITA MINKITISVK AYHTRTGEQH 130 140 150 160 170 180 TAMADGAATL RHRPHGVLAV FGPYNFPGHL PNGHIVPALL AGNTVIFKPS ELTPWSGEAV 190 200 210 220 230 240 VKLWEQAGLP PGVLNLVQGG RETGQALSAL SDLDGLLFTG SAGTGYQLHR QLAGQPEKIL 250 260 270 280 290 300 ALEMGGNNPL IVEDPEDIDA AVHLAIQSAF VTAGQRCTCA RRLLVKNGAQ GDAFLARLIE 310 320 330 340 350 360 VTARLVPDAW DAEPQPFIGG LISEQAANNV IHAWREHVAR GAKTLLEPKL VQPGTSLLTP 370 380 390 400 410 420 GIIDMSDARD IPDEEVFGPL LCVWRYDDFD SAIAMANNTR YGLSSGLISP DREKFDQLLI 430 440 450 460 470 480 EARAGIVNWN KPLTGAASTA PFGGVGASGN HRASAWYAAD YCAWPMASLE TPALTLPEAL 490 NPGLDFTQGN GHESA

References

[1]

"Complete sequence of chromosome of Enterobacter sp. 638." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Detter J.C., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Kim E., Taghavi S., Newman L., Vangronsveld J., van der Lelie D., Richardson P. Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000653 Genomic DNA. Translation: ABP60377.1.
RefSeq	YP_001176428.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5112437.
GenomeReviews	Gene locus Ent638_1698 in contig CP000653_GR.
KEGG	ent:Ent638_1698.
NMPDR	fig|399742.4.peg.1674.
Organism-specific databases
CMR	Search...
Family and domain databases
HAMAP	MF_01174. [Tree]
InterPro	IPR016160. Ald_DHase_CS. IPR016162. Ald_DHase_N. IPR015590. Aldehyde_DHase. IPR017649. SuccinylGlu_semiald_DH_AstD. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ASTD_ENT38

Accession

Primary (citable) accession number: A4W9J7

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	May 29, 2007
Last modified:	November 25, 2008
This is version 16 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)