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A4W8V0 (PNCB_ENT38) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Nicotinate phosphoribosyltransferase

Short name=NAPRTase
EC=6.3.4.21
Gene names
Name:pncB
Ordered Locus Names:Ent638_1450
OrganismEnterobacter sp. (strain 638) [Complete proteome] [HAMAP]
Taxonomic identifier399742 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEnterobacter

Protein attributes

Sequence length400 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP By similarity. HAMAP-Rule MF_00570

Catalytic activity

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate. HAMAP-Rule MF_00570

Pathway

Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1. HAMAP-Rule MF_00570

Sequence similarities

Belongs to the NAPRTase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 400400Nicotinate phosphoribosyltransferase HAMAP-Rule MF_00570
PRO_1000061168

Sequences

Sequence LengthMass (Da)Tools
A4W8V0 [UniParc].

Last modified May 29, 2007. Version 1.
Checksum: AA80BDC1F7F3D3A2

FASTA40045,932
        10         20         30         40         50         60 
MTQFASPVLH TLLDTDAYKL HMQQAVFHHY YDVQVAAEFR CRGDDLLGIY ADSIREQVDA 

        70         80         90        100        110        120 
MQHLALQDDE YQWLSGLPFF KADYLDWLRD FRFNPEQVTI TNDNGKLNIR LAGPWREVIM 

       130        140        150        160        170        180 
WEVPLLAVIS EIVHRYRSPE MGVEHALATL ESKLGEFAQM TESVDMSRFR LMDFGTRRRF 

       190        200        210        220        230        240 
SREVQQAIVK RLQQEPWFVG TSNYDLARRR NLTPMGTQAH EWFQAHQQIS PDLATSQRAA 

       250        260        270        280        290        300 
LAAWLEEYPD QLGIALTDCI TMDAFLRDFG PEFAQRYQGL RHDSGDPVEW GEKAIAHYKK 

       310        320        330        340        350        360 
LGIDPLTKVL VFSDNLDLSK ALELYRHFSA RVNLSFGIGT RLTCDIPQVK PLNIVIKLVE 

       370        380        390        400 
CNGKPVAKLS DSPGKTICHD KAFVRALRKA FDLPQIKKAS 

« Hide

References

[1]"Genome sequence of the plant growth promoting endophytic bacterium Enterobacter sp. 638."
Taghavi S., van der Lelie D., Hoffman A., Zhang Y.B., Walla M.D., Vangronsveld J., Newman L., Monchy S.
PLoS Genet. 6:E1000943-E1000943(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 638.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000653 Genomic DNA. Translation: ABP60130.1.
RefSeqYP_001176181.1. NC_009436.1.

3D structure databases

ProteinModelPortalA4W8V0.
SMRA4W8V0. Positions 2-377.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING399742.Ent638_1450.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABP60130; ABP60130; Ent638_1450.
GeneID5114415.
KEGGent:Ent638_1450.
PATRIC20412500. VBIEntSp101211_1586.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1488.
HOGENOMHOG000284928.
KOK00763.
OMAQAVFHRY.
OrthoDBEOG6X10XB.

Enzyme and pathway databases

BioCycESP399742:GJ0E-1490-MONOMER.
UniPathwayUPA00253; UER00457.

Family and domain databases

HAMAPMF_00570. NAPRTase.
InterProIPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view]
PfamPF04095. NAPRTase. 1 hit.
[Graphical view]
PIRSFPIRSF000484. NAPRT. 1 hit.
SUPFAMSSF51690. SSF51690. 1 hit.
TIGRFAMsTIGR01514. NAPRTase. 1 hit.
ProtoNetSearch...

Entry information

Entry namePNCB_ENT38
AccessionPrimary (citable) accession number: A4W8V0
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 29, 2007
Last modified: May 14, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways