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A4W8V0

- PNCB_ENT38

UniProt

A4W8V0 - PNCB_ENT38

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Protein

Nicotinate phosphoribosyltransferase

Gene
pncB, Ent638_1450
Organism
Enterobacter sp. (strain 638)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP By similarity.UniRule annotation

Catalytic activityi

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ligase activity Source: UniProtKB-KW
  2. nicotinate-nucleotide diphosphorylase (carboxylating) activity Source: InterPro
  3. nicotinate phosphoribosyltransferase activity Source: InterPro

GO - Biological processi

  1. NAD biosynthetic process Source: UniProtKB-UniPathway
  2. nicotinate nucleotide biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ligase, Transferase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Enzyme and pathway databases

BioCyciESP399742:GJ0E-1490-MONOMER.
UniPathwayiUPA00253; UER00457.

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate phosphoribosyltransferase (EC:6.3.4.21)
Short name:
NAPRTase
Gene namesi
Name:pncB
Ordered Locus Names:Ent638_1450
OrganismiEnterobacter sp. (strain 638)
Taxonomic identifieri399742 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEnterobacter
ProteomesiUP000000230: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 400400Nicotinate phosphoribosyltransferaseUniRule annotationPRO_1000061168Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi399742.Ent638_1450.

Structurei

3D structure databases

ProteinModelPortaliA4W8V0.
SMRiA4W8V0. Positions 2-377.

Family & Domainsi

Sequence similaritiesi

Belongs to the NAPRTase family.

Phylogenomic databases

eggNOGiCOG1488.
HOGENOMiHOG000284928.
KOiK00763.
OMAiQAVFHRY.
OrthoDBiEOG6X10XB.

Family and domain databases

HAMAPiMF_00570. NAPRTase.
InterProiIPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view]
PANTHERiPTHR11098. PTHR11098. 1 hit.
PfamiPF04095. NAPRTase. 1 hit.
[Graphical view]
PIRSFiPIRSF000484. NAPRT. 1 hit.
SUPFAMiSSF51690. SSF51690. 1 hit.
TIGRFAMsiTIGR01514. NAPRTase. 1 hit.

Sequencei

Sequence statusi: Complete.

A4W8V0-1 [UniParc]FASTAAdd to Basket

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MTQFASPVLH TLLDTDAYKL HMQQAVFHHY YDVQVAAEFR CRGDDLLGIY    50
ADSIREQVDA MQHLALQDDE YQWLSGLPFF KADYLDWLRD FRFNPEQVTI 100
TNDNGKLNIR LAGPWREVIM WEVPLLAVIS EIVHRYRSPE MGVEHALATL 150
ESKLGEFAQM TESVDMSRFR LMDFGTRRRF SREVQQAIVK RLQQEPWFVG 200
TSNYDLARRR NLTPMGTQAH EWFQAHQQIS PDLATSQRAA LAAWLEEYPD 250
QLGIALTDCI TMDAFLRDFG PEFAQRYQGL RHDSGDPVEW GEKAIAHYKK 300
LGIDPLTKVL VFSDNLDLSK ALELYRHFSA RVNLSFGIGT RLTCDIPQVK 350
PLNIVIKLVE CNGKPVAKLS DSPGKTICHD KAFVRALRKA FDLPQIKKAS 400
Length:400
Mass (Da):45,932
Last modified:May 29, 2007 - v1
Checksum:iAA80BDC1F7F3D3A2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000653 Genomic DNA. Translation: ABP60130.1.
RefSeqiWP_012016847.1. NC_009436.1.
YP_001176181.1. NC_009436.1.

Genome annotation databases

EnsemblBacteriaiABP60130; ABP60130; Ent638_1450.
GeneIDi5114415.
KEGGient:Ent638_1450.
PATRICi20412500. VBIEntSp101211_1586.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000653 Genomic DNA. Translation: ABP60130.1 .
RefSeqi WP_012016847.1. NC_009436.1.
YP_001176181.1. NC_009436.1.

3D structure databases

ProteinModelPortali A4W8V0.
SMRi A4W8V0. Positions 2-377.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 399742.Ent638_1450.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABP60130 ; ABP60130 ; Ent638_1450 .
GeneIDi 5114415.
KEGGi ent:Ent638_1450.
PATRICi 20412500. VBIEntSp101211_1586.

Phylogenomic databases

eggNOGi COG1488.
HOGENOMi HOG000284928.
KOi K00763.
OMAi QAVFHRY.
OrthoDBi EOG6X10XB.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00457 .
BioCyci ESP399742:GJ0E-1490-MONOMER.

Family and domain databases

HAMAPi MF_00570. NAPRTase.
InterProi IPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view ]
PANTHERi PTHR11098. PTHR11098. 1 hit.
Pfami PF04095. NAPRTase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000484. NAPRT. 1 hit.
SUPFAMi SSF51690. SSF51690. 1 hit.
TIGRFAMsi TIGR01514. NAPRTase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the plant growth promoting endophytic bacterium Enterobacter sp. 638."
    Taghavi S., van der Lelie D., Hoffman A., Zhang Y.B., Walla M.D., Vangronsveld J., Newman L., Monchy S.
    PLoS Genet. 6:E1000943-E1000943(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 638.

Entry informationi

Entry nameiPNCB_ENT38
AccessioniPrimary (citable) accession number: A4W8V0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 29, 2007
Last modified: September 3, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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