SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

A4W870

- PCP_ENT38

UniProt

A4W870 - PCP_ENT38

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Pyrrolidone-carboxylate peptidase
Gene
pcp, Ent638_1219
Organism
Enterobacter sp. (strain 638)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Removes 5-oxoproline from various penultimate amino acid residues except L-proline By similarity.UniRule annotation

Catalytic activityi

Release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei80 – 801 By similarity
Active sitei143 – 1431 By similarity
Active sitei166 – 1661 By similarity

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: UniProtKB-KW
  2. pyroglutamyl-peptidase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Enzyme and pathway databases

    BioCyciESP399742:GJ0E-1254-MONOMER.

    Protein family/group databases

    MEROPSiC15.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pyrrolidone-carboxylate peptidase (EC:3.4.19.3)
    Alternative name(s):
    5-oxoprolyl-peptidase
    Pyroglutamyl-peptidase I
    Short name:
    PGP-I
    Short name:
    Pyrase
    Gene namesi
    Name:pcp
    Ordered Locus Names:Ent638_1219
    OrganismiEnterobacter sp. (strain 638)
    Taxonomic identifieri399742 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEnterobacter
    ProteomesiUP000000230: Chromosome

    Subcellular locationi

    Cytoplasm By similarity UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 214214Pyrrolidone-carboxylate peptidaseUniRule annotation
    PRO_1000060080Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer By similarity.UniRule annotation

    Protein-protein interaction databases

    STRINGi399742.Ent638_1219.

    Structurei

    3D structure databases

    ProteinModelPortaliA4W870.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase C15 family.

    Phylogenomic databases

    eggNOGiCOG2039.
    HOGENOMiHOG000242641.
    KOiK01304.
    OMAiAKQLPCV.
    OrthoDBiEOG6X1124.

    Family and domain databases

    Gene3Di3.40.630.20. 1 hit.
    HAMAPiMF_00417. Pyrrolid_peptidase.
    InterProiIPR000816. Peptidase_C15.
    IPR016125. Peptidase_C15-like.
    [Graphical view]
    PANTHERiPTHR23402. PTHR23402. 1 hit.
    PfamiPF01470. Peptidase_C15. 1 hit.
    [Graphical view]
    PIRSFiPIRSF015592. Prld-crbxl_pptds. 1 hit.
    PRINTSiPR00706. PYROGLUPTASE.
    PROSITEiPS01334. PYRASE_CYS. 1 hit.
    PS01333. PYRASE_GLU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A4W870-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRHILVTGFE PFGGETLNPS WEVVKQLEGM TIDDCRVVTR QLPCVFGESL    50
    TLLNSAIDEL NPTVVIAVGQ AGGRVDITVE RVGINVDDAR IPDNRGQQPI 100
    DVAIVPDGPA AWFSSLPIKA MVAAMREKGI PASVSQTAGT FVCNHVMYGL 150
    LHKIRERTNV KGGFIHIPYL PEQAAAHAGA PSMATQTVKA ALEIALTVAL 200
    RQSSDINAVG GATH 214
    Length:214
    Mass (Da):22,770
    Last modified:May 29, 2007 - v1
    Checksum:i45EB5FE4B1571986
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000653 Genomic DNA. Translation: ABP59900.1.
    RefSeqiWP_012016619.1. NC_009436.1.
    YP_001175951.1. NC_009436.1.

    Genome annotation databases

    EnsemblBacteriaiABP59900; ABP59900; Ent638_1219.
    GeneIDi5114176.
    KEGGient:Ent638_1219.
    PATRICi20412028. VBIEntSp101211_1355.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000653 Genomic DNA. Translation: ABP59900.1 .
    RefSeqi WP_012016619.1. NC_009436.1.
    YP_001175951.1. NC_009436.1.

    3D structure databases

    ProteinModelPortali A4W870.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 399742.Ent638_1219.

    Protein family/group databases

    MEROPSi C15.001.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABP59900 ; ABP59900 ; Ent638_1219 .
    GeneIDi 5114176.
    KEGGi ent:Ent638_1219.
    PATRICi 20412028. VBIEntSp101211_1355.

    Phylogenomic databases

    eggNOGi COG2039.
    HOGENOMi HOG000242641.
    KOi K01304.
    OMAi AKQLPCV.
    OrthoDBi EOG6X1124.

    Enzyme and pathway databases

    BioCyci ESP399742:GJ0E-1254-MONOMER.

    Family and domain databases

    Gene3Di 3.40.630.20. 1 hit.
    HAMAPi MF_00417. Pyrrolid_peptidase.
    InterProi IPR000816. Peptidase_C15.
    IPR016125. Peptidase_C15-like.
    [Graphical view ]
    PANTHERi PTHR23402. PTHR23402. 1 hit.
    Pfami PF01470. Peptidase_C15. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF015592. Prld-crbxl_pptds. 1 hit.
    PRINTSi PR00706. PYROGLUPTASE.
    PROSITEi PS01334. PYRASE_CYS. 1 hit.
    PS01333. PYRASE_GLU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the plant growth promoting endophytic bacterium Enterobacter sp. 638."
      Taghavi S., van der Lelie D., Hoffman A., Zhang Y.B., Walla M.D., Vangronsveld J., Newman L., Monchy S.
      PLoS Genet. 6:E1000943-E1000943(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 638.

    Entry informationi

    Entry nameiPCP_ENT38
    AccessioniPrimary (citable) accession number: A4W870
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: May 29, 2007
    Last modified: September 3, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

    Similar proteinsi