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A4W827

- SYL_ENT38

UniProt

A4W827 - SYL_ENT38

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Protein
Leucine--tRNA ligase
Gene
leuS, Ent638_1176
Organism
Enterobacter sp. (strain 638)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei656 – 6561ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciESP399742:GJ0E-1204-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:Ent638_1176
OrganismiEnterobacter sp. (strain 638)
Taxonomic identifieri399742 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEnterobacter
ProteomesiUP000000230: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 894894Leucine--tRNA ligaseUniRule annotation
PRO_1000057344Add
BLAST

Proteomic databases

PRIDEiA4W827.

Interactioni

Protein-protein interaction databases

STRINGi399742.Ent638_1176.

Structurei

3D structure databases

ProteinModelPortaliA4W827.
SMRiA4W827. Positions 228-447.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionUniRule annotation
Add
BLAST
Motifi653 – 6575"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiMAFAGPP.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 2 hits.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 2 hits.
TIGRFAMsiTIGR00396. leuS_bact. 2 hits.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4W827-1 [UniParc]FASTAAdd to Basket

« Hide

MQEQYRPEEI ETKVQQHWDE KRTFEVTEDE SKEKYYCLSM LPYPSGRLHM    50
GHVRNYTIGD VIARYQRMLG KNVLQPIGWD AFGLPAEGAA VKNNTAPAPW 100
TYDNIAYMKN QLKMLGFGYD WSRELATCTP EYYRWEQKFF TELYKKGLVY 150
KKTSAVNWCP NDQTVLANEQ VIDGCCWRCD TKVERKEIPQ WFIKITAYAD 200
ELLRDLDNLD HWPDTVKTMQ RNWIGRSEGV EITFNVENSD QKLTVYTTRP 250
DTFMGATYLA VAAGHPLAQQ AAANNPALAA FIDECRNTKV AEADMATMEK 300
KGVATGFNAI HPLTGEAVPV WAANFVLMEY GTGAVMAVPG HDQRDYEFAT 350
KYGLPIKRVI KSPEQKAYEH ALEYGLGSAK NPNDFEPLTH NQRSEFLGLL 400
TAELNKPYLE KDGETYNSGK FDGLSFEAAF NSIAAALITK GVGERKVNYR 450
LRDWGVSRQR YWGAPIPMVT LEDGTVLPTP EDQLPVILPE DVVMDGISSP 500
IKADPEWAKT TVNGQPALRE TDTFDTFMES SWYYARYTCP QYQEGMLDSK 550
AANYWLPVDI YIGGIEHAIM HLLYFRFFHK LMRDAGLVNS DEPAKQLLCQ 600
GMVLADAFYY VGVNGERNWV SPVDAIVERD EKGRIVKAKD AAGNELVYTG 650
MSKMSKSKNN GIDPQVMVER YGADTVRLFM MFASPADMTL EWQESGVEGA 700
NRFLKRVWKL VYEHTSQGEA PALNVGALSE DQQALRRDVH KTIAKVTDDI 750
GRRQTFNTAI AAIMELMNKL ARAPQEGEQD RALMREALLA VVRMLNPFTP 800
HACFTLWQEL KGEGDIDNAP WPVADESAMV ENTTLVVVQV NGKVRGKITV 850
AVDATEEQVR ERAGQEHLVA KYLEGVTVRK VIYVPGKLLN LVVG 894
Length:894
Mass (Da):100,942
Last modified:May 29, 2007 - v1
Checksum:i96A990F72D243966
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000653 Genomic DNA. Translation: ABP59857.1.
RefSeqiWP_012016576.1. NC_009436.1.
YP_001175908.1. NC_009436.1.

Genome annotation databases

EnsemblBacteriaiABP59857; ABP59857; Ent638_1176.
GeneIDi5114125.
KEGGient:Ent638_1176.
PATRICi20411928. VBIEntSp101211_1312.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000653 Genomic DNA. Translation: ABP59857.1 .
RefSeqi WP_012016576.1. NC_009436.1.
YP_001175908.1. NC_009436.1.

3D structure databases

ProteinModelPortali A4W827.
SMRi A4W827. Positions 228-447.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 399742.Ent638_1176.

Proteomic databases

PRIDEi A4W827.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABP59857 ; ABP59857 ; Ent638_1176 .
GeneIDi 5114125.
KEGGi ent:Ent638_1176.
PATRICi 20411928. VBIEntSp101211_1312.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi MAFAGPP.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci ESP399742:GJ0E-1204-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 2 hits.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 2 hits.
TIGRFAMsi TIGR00396. leuS_bact. 2 hits.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the plant growth promoting endophytic bacterium Enterobacter sp. 638."
    Taghavi S., van der Lelie D., Hoffman A., Zhang Y.B., Walla M.D., Vangronsveld J., Newman L., Monchy S.
    PLoS Genet. 6:E1000943-E1000943(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 638.

Entry informationi

Entry nameiSYL_ENT38
AccessioniPrimary (citable) accession number: A4W827
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 29, 2007
Last modified: September 3, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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