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Reviewed, UniProtKB/Swiss-Prot A4W7Z3 (MTNC_ENT38)

Last modified February 9, 2010. Version 22. Feed History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Enolase-phosphatase E1
    EC=3.1.3.77
Alternative name(s):
    2,3-diketo-5-methylthio-1-phosphopentane phosphatase
Gene names
Name: mtnC
Ordered Locus Names: Ent638_1142
OrganismEnterobacter sp. (strain 638) [Complete proteome] [HAMAP]
Taxonomic identifier399742 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEnterobacter

Protein attributes

Sequence length229 AA.
Sequence statusComplete.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) By similarity. HAMAP MF_01681

Catalytic activity

5-(methylthio)-2,3-dioxopentyl phosphate + H2O = 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate. HAMAP MF_01681

Cofactor

Binds 1 magnesium ion per subunit By similarity. HAMAP MF_01681

Pathway

Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 3/6. HAMAP MF_01681

Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 4/6.

Subunit structure

Monomer By similarity. HAMAP MF_01681

Sequence similarities

Belongs to the HAD-like hydrolase superfamily. MasA/mtnC family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 229229Enolase-phosphatase E1 HAMAP MF_01681
PRO_0000357363

Sequences

Sequence LengthMass (Da)Tools
A4W7Z3-1 [UniParc].

Last modified May 29, 2007. Version 1.
Checksum: 8A478773CE5DB3BF

FASTA22925,503
        10         20         30         40         50         60 
MIRAIVTDIE GTTSDIRFVH NVLFPYARER LAAFVTAQQY AEPVKSILDN LRDEIAAPHA 

        70         80         90        100        110        120 
TIGELVDALF TFMDEDRKST ALKALQGIIW QDGYVNGDFT GQLYPDVLPA LEKWKAQGID 

       130        140        150        160        170        180 
LYVYSSGSVA AQKLLFGYSD EGDITHLFSG YFDTRVGAKR DVQSYQNIAA QIGVSPSQIL 

       190        200        210        220 
FLSDIHEELD AAEQAGFRTL QLIRGDDDGA SHHHQVHQFD EINPEQIPS 

« Hide

References

[1]"Complete sequence of chromosome of Enterobacter sp. 638."
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Detter J.C., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Kim E., Taghavi S., Newman L., Vangronsveld J., van der Lelie D., Richardson P.
Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000653 Genomic DNA. Translation: ABP59823.1.
RefSeqYP_001175874.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGA4W7Z3.

Genome annotation databases

GeneID5114091.
GenomeReviewsGene locus Ent638_1142 in contig CP000653_GR.
KEGGent:Ent638_1142.
NMPDRfig|399742.4.peg.1149.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG4229.
HOGENOMHBG294242.
OMATTDLNFI.
PhylomeDBA4W7Z3.

Family and domain databases

HAMAPMF_01681. Salvage_MtnC.
[Tree]
InterProIPR005834. Dehalogen-like_hydro.
IPR010041. Enolase_ppase.
IPR005833. Haloacid_DH/epoxide_hydro.
[Graphical view]
PANTHERPTHR20371. Enolase_ppase. 1 hit.
PfamPF00702. Hydrolase. 1 hit.
[Graphical view]
PRINTSPR00413. HADHALOGNASE.
TIGRFAMsTIGR01691. enolase-ppase. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMTNC_ENT38
AccessionPrimary (citable) accession number: A4W7Z3
Entry history
Integrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: May 29, 2007
Last modified: February 9, 2010
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents