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A4W6S7

- LPXB_ENT38

UniProt

A4W6S7 - LPXB_ENT38

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Protein
Lipid-A-disaccharide synthase
Gene
lpxB, Ent638_0720
Organism
Enterobacter sp. (strain 638)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciESP399742:GJ0E-738-MONOMER.
UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthase (EC:2.4.1.182)
Gene namesi
Name:lpxB
Ordered Locus Names:Ent638_0720
OrganismiEnterobacter sp. (strain 638)
Taxonomic identifieri399742 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEnterobacter
ProteomesiUP000000230: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 382382Lipid-A-disaccharide synthaseUniRule annotation
PRO_1000060771Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi399742.Ent638_0720.

Structurei

3D structure databases

ProteinModelPortaliA4W6S7.

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018003.
KOiK00748.
OMAiVSPITYR.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

A4W6S7-1 [UniParc]FASTAAdd to Basket

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MVDNRPLTIA LVAGETSGDI LGAGLIRALK AREPNARFVG VAGPLMQAEG    50
CEAWYEMEEL AVMGIVEVLG RLRRLLHIRA DLTGRFTDLK PDVFVGIDAP 100
DFNITLEGNL KKQGIKTIHY VSPSVWAWRQ KRVFKIGRST DMVLAFLPFE 150
KAFYDRFNVP CRFIGHTMAD AMPLDPDKNA ARDSLGIPHD AHCLALLPGS 200
RGAEVEMLSA DFLRTAQILR QTYPDLEVVV PLVNAKRREQ FERIKAAVAP 250
DLHIHLLDGK GREAMVASDA ALLASGTAAL ECMLAKCPMV VGYRMKPFTF 300
WLAKRLVKTD YVSLPNLLAG RELVKELLQD ECQPQALADA LLPLLADGKT 350
RHQMHDTFRE LHQQIRCNAD EQAADAVMEL AQ 382
Length:382
Mass (Da):42,414
Last modified:May 29, 2007 - v1
Checksum:iF58C239A9246CA78
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000653 Genomic DNA. Translation: ABP59407.1.
RefSeqiWP_012016128.1. NC_009436.1.
YP_001175458.1. NC_009436.1.

Genome annotation databases

EnsemblBacteriaiABP59407; ABP59407; Ent638_0720.
GeneIDi5111989.
KEGGient:Ent638_0720.
PATRICi20410992. VBIEntSp101211_0853.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000653 Genomic DNA. Translation: ABP59407.1 .
RefSeqi WP_012016128.1. NC_009436.1.
YP_001175458.1. NC_009436.1.

3D structure databases

ProteinModelPortali A4W6S7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 399742.Ent638_0720.

Protein family/group databases

CAZyi GT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABP59407 ; ABP59407 ; Ent638_0720 .
GeneIDi 5111989.
KEGGi ent:Ent638_0720.
PATRICi 20410992. VBIEntSp101211_0853.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018003.
KOi K00748.
OMAi VSPITYR.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci ESP399742:GJ0E-738-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the plant growth promoting endophytic bacterium Enterobacter sp. 638."
    Taghavi S., van der Lelie D., Hoffman A., Zhang Y.B., Walla M.D., Vangronsveld J., Newman L., Monchy S.
    PLoS Genet. 6:E1000943-E1000943(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 638.

Entry informationi

Entry nameiLPXB_ENT38
AccessioniPrimary (citable) accession number: A4W6S7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 29, 2007
Last modified: September 3, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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