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A4W6S7

- LPXB_ENT38

UniProt

A4W6S7 - LPXB_ENT38

Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Enterobacter sp. (strain 638)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (29 May 2007)
      Previous versions | rss
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    Functioni

    Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

    Catalytic activityi

    UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid A biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BioCyciESP399742:GJ0E-738-MONOMER.
    UniPathwayiUPA00359; UER00481.

    Protein family/group databases

    CAZyiGT19. Glycosyltransferase Family 19.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
    Gene namesi
    Name:lpxBUniRule annotation
    Ordered Locus Names:Ent638_0720
    OrganismiEnterobacter sp. (strain 638)
    Taxonomic identifieri399742 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEnterobacter
    ProteomesiUP000000230: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 382382Lipid-A-disaccharide synthasePRO_1000060771Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi399742.Ent638_0720.

    Structurei

    3D structure databases

    ProteinModelPortaliA4W6S7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LpxB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0763.
    HOGENOMiHOG000018003.
    KOiK00748.
    OMAiVSPITYR.
    OrthoDBiEOG6FBWZR.

    Family and domain databases

    HAMAPiMF_00392. LpxB.
    InterProiIPR003835. Glyco_trans_19.
    [Graphical view]
    PfamiPF02684. LpxB. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00215. lpxB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A4W6S7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVDNRPLTIA LVAGETSGDI LGAGLIRALK AREPNARFVG VAGPLMQAEG    50
    CEAWYEMEEL AVMGIVEVLG RLRRLLHIRA DLTGRFTDLK PDVFVGIDAP 100
    DFNITLEGNL KKQGIKTIHY VSPSVWAWRQ KRVFKIGRST DMVLAFLPFE 150
    KAFYDRFNVP CRFIGHTMAD AMPLDPDKNA ARDSLGIPHD AHCLALLPGS 200
    RGAEVEMLSA DFLRTAQILR QTYPDLEVVV PLVNAKRREQ FERIKAAVAP 250
    DLHIHLLDGK GREAMVASDA ALLASGTAAL ECMLAKCPMV VGYRMKPFTF 300
    WLAKRLVKTD YVSLPNLLAG RELVKELLQD ECQPQALADA LLPLLADGKT 350
    RHQMHDTFRE LHQQIRCNAD EQAADAVMEL AQ 382
    Length:382
    Mass (Da):42,414
    Last modified:May 29, 2007 - v1
    Checksum:iF58C239A9246CA78
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000653 Genomic DNA. Translation: ABP59407.1.
    RefSeqiWP_012016128.1. NC_009436.1.
    YP_001175458.1. NC_009436.1.

    Genome annotation databases

    EnsemblBacteriaiABP59407; ABP59407; Ent638_0720.
    GeneIDi5111989.
    KEGGient:Ent638_0720.
    PATRICi20410992. VBIEntSp101211_0853.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000653 Genomic DNA. Translation: ABP59407.1 .
    RefSeqi WP_012016128.1. NC_009436.1.
    YP_001175458.1. NC_009436.1.

    3D structure databases

    ProteinModelPortali A4W6S7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 399742.Ent638_0720.

    Protein family/group databases

    CAZyi GT19. Glycosyltransferase Family 19.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABP59407 ; ABP59407 ; Ent638_0720 .
    GeneIDi 5111989.
    KEGGi ent:Ent638_0720.
    PATRICi 20410992. VBIEntSp101211_0853.

    Phylogenomic databases

    eggNOGi COG0763.
    HOGENOMi HOG000018003.
    KOi K00748.
    OMAi VSPITYR.
    OrthoDBi EOG6FBWZR.

    Enzyme and pathway databases

    UniPathwayi UPA00359 ; UER00481 .
    BioCyci ESP399742:GJ0E-738-MONOMER.

    Family and domain databases

    HAMAPi MF_00392. LpxB.
    InterProi IPR003835. Glyco_trans_19.
    [Graphical view ]
    Pfami PF02684. LpxB. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00215. lpxB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the plant growth promoting endophytic bacterium Enterobacter sp. 638."
      Taghavi S., van der Lelie D., Hoffman A., Zhang Y.B., Walla M.D., Vangronsveld J., Newman L., Monchy S.
      PLoS Genet. 6:E1000943-E1000943(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 638.

    Entry informationi

    Entry nameiLPXB_ENT38
    AccessioniPrimary (citable) accession number: A4W6S7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: May 29, 2007
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3