Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

A4W6K6

- GUAC_ENT38

UniProt

A4W6K6 - GUAC_ENT38

Protein

GMP reductase

Gene

guaC

Organism
Enterobacter sp. (strain 638)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (29 May 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.UniRule annotation

    Catalytic activityi

    Inosine 5'-phosphate + NH3 + NADP+ = guanosine 5'-phosphate + NADPH.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi181 – 1811Potassium; via carbonyl oxygenUniRule annotation
    Metal bindingi183 – 1831Potassium; via carbonyl oxygenUniRule annotation
    Active sitei186 – 1861Thioimidate intermediateUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi108 – 13124NADPUniRule annotationAdd
    BLAST
    Nucleotide bindingi216 – 23924NADP; ribose moietyUniRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. GMP reductase activity Source: UniProtKB-HAMAP
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. purine nucleotide metabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Metal-binding, NADP, Potassium

    Enzyme and pathway databases

    BioCyciESP399742:GJ0E-667-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GMP reductaseUniRule annotation (EC:1.7.1.7UniRule annotation)
    Alternative name(s):
    Guanosine 5'-monophosphate oxidoreductaseUniRule annotation
    Short name:
    Guanosine monophosphate reductaseUniRule annotation
    Gene namesi
    Name:guaCUniRule annotation
    Ordered Locus Names:Ent638_0649
    OrganismiEnterobacter sp. (strain 638)
    Taxonomic identifieri399742 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEnterobacter
    ProteomesiUP000000230: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. GMP reductase complex Source: UniProtKB-EC

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 347347GMP reductasePRO_1000061237Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi399742.Ent638_0649.

    Structurei

    3D structure databases

    ProteinModelPortaliA4W6K6.
    SMRiA4W6K6. Positions 3-338.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0516.
    HOGENOMiHOG000165756.
    KOiK00364.
    OMAiCSCAGDV.
    OrthoDBiEOG6GTZPV.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_00596. GMP_reduct_type1.
    InterProiIPR013785. Aldolase_TIM.
    IPR005993. GuaC_type_1.
    IPR015875. IMP_DH/GMP_Rdtase_CS.
    IPR001093. IMP_DH_GMPRt.
    [Graphical view]
    PfamiPF00478. IMPDH. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000235. GMP_reductase. 1 hit.
    TIGRFAMsiTIGR01305. GMP_reduct_1. 1 hit.
    PROSITEiPS00487. IMP_DH_GMP_RED. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A4W6K6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRIEEDLKLG FKDVLIRPKR STLKSRSDVE LERQFTFKHS GQTWSGVPII    50
    AANMDTVGTF AMATALASFD ILTAVHKHYS VEEWNAFAAS ASADVLKHVM 100
    VSTGTSDTDF EKTKQILIAN PALNFLCIDV ANGYSEHFVQ FVSKAREAWP 150
    DKTIIAGNVV TGEMCEELIL AGADIVKVGI GPGSVCTTRV KTGVGYPQLS 200
    AVIECADAAH GLGGQIISDG GCTMPGDVAK AFGGGADFVM LGGMLAGHEE 250
    SGGTVVEENG EKFMLFYGMS SESAMNRHVG GVAQYRAAEG KTVKLPLRGP 300
    VENTARDVMG GLRSACTYVG ASRLKELTKR TTFIRVQEQE NRIFNSL 347
    Length:347
    Mass (Da):37,211
    Last modified:May 29, 2007 - v1
    Checksum:iD37597A3D7C86A9A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000653 Genomic DNA. Translation: ABP59336.1.
    RefSeqiWP_012016057.1. NC_009436.1.
    YP_001175387.1. NC_009436.1.

    Genome annotation databases

    EnsemblBacteriaiABP59336; ABP59336; Ent638_0649.
    GeneIDi5113688.
    KEGGient:Ent638_0649.
    PATRICi20410844. VBIEntSp101211_0779.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000653 Genomic DNA. Translation: ABP59336.1 .
    RefSeqi WP_012016057.1. NC_009436.1.
    YP_001175387.1. NC_009436.1.

    3D structure databases

    ProteinModelPortali A4W6K6.
    SMRi A4W6K6. Positions 3-338.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 399742.Ent638_0649.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABP59336 ; ABP59336 ; Ent638_0649 .
    GeneIDi 5113688.
    KEGGi ent:Ent638_0649.
    PATRICi 20410844. VBIEntSp101211_0779.

    Phylogenomic databases

    eggNOGi COG0516.
    HOGENOMi HOG000165756.
    KOi K00364.
    OMAi CSCAGDV.
    OrthoDBi EOG6GTZPV.

    Enzyme and pathway databases

    BioCyci ESP399742:GJ0E-667-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_00596. GMP_reduct_type1.
    InterProi IPR013785. Aldolase_TIM.
    IPR005993. GuaC_type_1.
    IPR015875. IMP_DH/GMP_Rdtase_CS.
    IPR001093. IMP_DH_GMPRt.
    [Graphical view ]
    Pfami PF00478. IMPDH. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000235. GMP_reductase. 1 hit.
    TIGRFAMsi TIGR01305. GMP_reduct_1. 1 hit.
    PROSITEi PS00487. IMP_DH_GMP_RED. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the plant growth promoting endophytic bacterium Enterobacter sp. 638."
      Taghavi S., van der Lelie D., Hoffman A., Zhang Y.B., Walla M.D., Vangronsveld J., Newman L., Monchy S.
      PLoS Genet. 6:E1000943-E1000943(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 638.

    Entry informationi

    Entry nameiGUAC_ENT38
    AccessioniPrimary (citable) accession number: A4W6K6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: May 29, 2007
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3