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A4W6K6

- GUAC_ENT38

UniProt

A4W6K6 - GUAC_ENT38

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Protein
GMP reductase
Gene
guaC, Ent638_0649
Organism
Enterobacter sp. (strain 638)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides By similarity.UniRule annotation

Catalytic activityi

Inosine 5'-phosphate + NH3 + NADP+ = guanosine 5'-phosphate + NADPH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi181 – 1811Potassium; via carbonyl oxygen By similarity
Metal bindingi183 – 1831Potassium; via carbonyl oxygen By similarity
Active sitei186 – 1861Thioimidate intermediate By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi108 – 13124NADP By similarity
Add
BLAST
Nucleotide bindingi216 – 23924NADP; ribose moiety By similarity
Add
BLAST

GO - Molecular functioni

  1. GMP reductase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. purine nucleotide metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Metal-binding, NADP, Potassium

Enzyme and pathway databases

BioCyciESP399742:GJ0E-667-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
GMP reductase (EC:1.7.1.7)
Alternative name(s):
Guanosine 5'-monophosphate oxidoreductase
Short name:
Guanosine monophosphate reductase
Gene namesi
Name:guaC
Ordered Locus Names:Ent638_0649
OrganismiEnterobacter sp. (strain 638)
Taxonomic identifieri399742 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEnterobacter
ProteomesiUP000000230: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. GMP reductase complex Source: UniProtKB-EC
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 347347GMP reductaseUniRule annotation
PRO_1000061237Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi399742.Ent638_0649.

Structurei

3D structure databases

ProteinModelPortaliA4W6K6.
SMRiA4W6K6. Positions 3-338.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0516.
HOGENOMiHOG000165756.
KOiK00364.
OMAiCSCAGDV.
OrthoDBiEOG6GTZPV.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00596. GMP_reduct_type1.
InterProiIPR013785. Aldolase_TIM.
IPR005993. GuaC_type_1.
IPR015875. IMP_DH/GMP_Rdtase_CS.
IPR001093. IMP_DH_GMPRt.
[Graphical view]
PfamiPF00478. IMPDH. 1 hit.
[Graphical view]
PIRSFiPIRSF000235. GMP_reductase. 1 hit.
TIGRFAMsiTIGR01305. GMP_reduct_1. 1 hit.
PROSITEiPS00487. IMP_DH_GMP_RED. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4W6K6-1 [UniParc]FASTAAdd to Basket

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MRIEEDLKLG FKDVLIRPKR STLKSRSDVE LERQFTFKHS GQTWSGVPII    50
AANMDTVGTF AMATALASFD ILTAVHKHYS VEEWNAFAAS ASADVLKHVM 100
VSTGTSDTDF EKTKQILIAN PALNFLCIDV ANGYSEHFVQ FVSKAREAWP 150
DKTIIAGNVV TGEMCEELIL AGADIVKVGI GPGSVCTTRV KTGVGYPQLS 200
AVIECADAAH GLGGQIISDG GCTMPGDVAK AFGGGADFVM LGGMLAGHEE 250
SGGTVVEENG EKFMLFYGMS SESAMNRHVG GVAQYRAAEG KTVKLPLRGP 300
VENTARDVMG GLRSACTYVG ASRLKELTKR TTFIRVQEQE NRIFNSL 347
Length:347
Mass (Da):37,211
Last modified:May 29, 2007 - v1
Checksum:iD37597A3D7C86A9A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000653 Genomic DNA. Translation: ABP59336.1.
RefSeqiWP_012016057.1. NC_009436.1.
YP_001175387.1. NC_009436.1.

Genome annotation databases

EnsemblBacteriaiABP59336; ABP59336; Ent638_0649.
GeneIDi5113688.
KEGGient:Ent638_0649.
PATRICi20410844. VBIEntSp101211_0779.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000653 Genomic DNA. Translation: ABP59336.1 .
RefSeqi WP_012016057.1. NC_009436.1.
YP_001175387.1. NC_009436.1.

3D structure databases

ProteinModelPortali A4W6K6.
SMRi A4W6K6. Positions 3-338.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 399742.Ent638_0649.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABP59336 ; ABP59336 ; Ent638_0649 .
GeneIDi 5113688.
KEGGi ent:Ent638_0649.
PATRICi 20410844. VBIEntSp101211_0779.

Phylogenomic databases

eggNOGi COG0516.
HOGENOMi HOG000165756.
KOi K00364.
OMAi CSCAGDV.
OrthoDBi EOG6GTZPV.

Enzyme and pathway databases

BioCyci ESP399742:GJ0E-667-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_00596. GMP_reduct_type1.
InterProi IPR013785. Aldolase_TIM.
IPR005993. GuaC_type_1.
IPR015875. IMP_DH/GMP_Rdtase_CS.
IPR001093. IMP_DH_GMPRt.
[Graphical view ]
Pfami PF00478. IMPDH. 1 hit.
[Graphical view ]
PIRSFi PIRSF000235. GMP_reductase. 1 hit.
TIGRFAMsi TIGR01305. GMP_reduct_1. 1 hit.
PROSITEi PS00487. IMP_DH_GMP_RED. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the plant growth promoting endophytic bacterium Enterobacter sp. 638."
    Taghavi S., van der Lelie D., Hoffman A., Zhang Y.B., Walla M.D., Vangronsveld J., Newman L., Monchy S.
    PLoS Genet. 6:E1000943-E1000943(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 638.

Entry informationi

Entry nameiGUAC_ENT38
AccessioniPrimary (citable) accession number: A4W6K6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 29, 2007
Last modified: September 3, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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