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Protein

GMP reductase

Gene

guaC

Organism
Enterobacter sp. (strain 638)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.UniRule annotation

Catalytic activityi

Inosine 5'-phosphate + NH3 + NADP+ = guanosine 5'-phosphate + NADPH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi181Potassium; via carbonyl oxygenUniRule annotation1
Metal bindingi183Potassium; via carbonyl oxygenUniRule annotation1
Active sitei186Thioimidate intermediateUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi108 – 131NADPUniRule annotationAdd BLAST24
Nucleotide bindingi216 – 239NADP; ribose moietyUniRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Metal-binding, NADP, Potassium

Names & Taxonomyi

Protein namesi
Recommended name:
GMP reductaseUniRule annotation (EC:1.7.1.7UniRule annotation)
Alternative name(s):
Guanosine 5'-monophosphate oxidoreductaseUniRule annotation
Short name:
Guanosine monophosphate reductaseUniRule annotation
Gene namesi
Name:guaCUniRule annotation
Ordered Locus Names:Ent638_0649
OrganismiEnterobacter sp. (strain 638)
Taxonomic identifieri399742 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEnterobacter
Proteomesi
  • UP000000230 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000612371 – 347GMP reductaseAdd BLAST347

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi399742.Ent638_0649.

Structurei

3D structure databases

ProteinModelPortaliA4W6K6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CP4. Bacteria.
COG0516. LUCA.
HOGENOMiHOG000165756.
KOiK00364.
OMAiCSCAGDV.

Family and domain databases

CDDicd00381. IMPDH. 1 hit.
Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00596. GMP_reduct_type1. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR005993. GMPR.
IPR015875. IMP_DH/GMP_Rdtase_CS.
IPR001093. IMP_DH_GMPRt.
[Graphical view]
PfamiPF00478. IMPDH. 1 hit.
[Graphical view]
PIRSFiPIRSF000235. GMP_reductase. 1 hit.
TIGRFAMsiTIGR01305. GMP_reduct_1. 1 hit.
PROSITEiPS00487. IMP_DH_GMP_RED. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4W6K6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRIEEDLKLG FKDVLIRPKR STLKSRSDVE LERQFTFKHS GQTWSGVPII
60 70 80 90 100
AANMDTVGTF AMATALASFD ILTAVHKHYS VEEWNAFAAS ASADVLKHVM
110 120 130 140 150
VSTGTSDTDF EKTKQILIAN PALNFLCIDV ANGYSEHFVQ FVSKAREAWP
160 170 180 190 200
DKTIIAGNVV TGEMCEELIL AGADIVKVGI GPGSVCTTRV KTGVGYPQLS
210 220 230 240 250
AVIECADAAH GLGGQIISDG GCTMPGDVAK AFGGGADFVM LGGMLAGHEE
260 270 280 290 300
SGGTVVEENG EKFMLFYGMS SESAMNRHVG GVAQYRAAEG KTVKLPLRGP
310 320 330 340
VENTARDVMG GLRSACTYVG ASRLKELTKR TTFIRVQEQE NRIFNSL
Length:347
Mass (Da):37,211
Last modified:May 29, 2007 - v1
Checksum:iD37597A3D7C86A9A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000653 Genomic DNA. Translation: ABP59336.1.
RefSeqiWP_012016057.1. NC_009436.1.

Genome annotation databases

EnsemblBacteriaiABP59336; ABP59336; Ent638_0649.
KEGGient:Ent638_0649.
PATRICi20410844. VBIEntSp101211_0779.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000653 Genomic DNA. Translation: ABP59336.1.
RefSeqiWP_012016057.1. NC_009436.1.

3D structure databases

ProteinModelPortaliA4W6K6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi399742.Ent638_0649.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABP59336; ABP59336; Ent638_0649.
KEGGient:Ent638_0649.
PATRICi20410844. VBIEntSp101211_0779.

Phylogenomic databases

eggNOGiENOG4105CP4. Bacteria.
COG0516. LUCA.
HOGENOMiHOG000165756.
KOiK00364.
OMAiCSCAGDV.

Family and domain databases

CDDicd00381. IMPDH. 1 hit.
Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00596. GMP_reduct_type1. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR005993. GMPR.
IPR015875. IMP_DH/GMP_Rdtase_CS.
IPR001093. IMP_DH_GMPRt.
[Graphical view]
PfamiPF00478. IMPDH. 1 hit.
[Graphical view]
PIRSFiPIRSF000235. GMP_reductase. 1 hit.
TIGRFAMsiTIGR01305. GMP_reduct_1. 1 hit.
PROSITEiPS00487. IMP_DH_GMP_RED. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGUAC_ENT38
AccessioniPrimary (citable) accession number: A4W6K6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 29, 2007
Last modified: November 2, 2016
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.