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A4W6K6

- GUAC_ENT38

UniProt

A4W6K6 - GUAC_ENT38

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Protein

GMP reductase

Gene

guaC

Organism
Enterobacter sp. (strain 638)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.UniRule annotation

Catalytic activityi

Inosine 5'-phosphate + NH3 + NADP+ = guanosine 5'-phosphate + NADPH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi181 – 1811Potassium; via carbonyl oxygenUniRule annotation
Metal bindingi183 – 1831Potassium; via carbonyl oxygenUniRule annotation
Active sitei186 – 1861Thioimidate intermediateUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi108 – 13124NADPUniRule annotationAdd
BLAST
Nucleotide bindingi216 – 23924NADP; ribose moietyUniRule annotationAdd
BLAST

GO - Molecular functioni

  1. GMP reductase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. purine nucleotide metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Metal-binding, NADP, Potassium

Enzyme and pathway databases

BioCyciESP399742:GJ0E-667-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
GMP reductaseUniRule annotation (EC:1.7.1.7UniRule annotation)
Alternative name(s):
Guanosine 5'-monophosphate oxidoreductaseUniRule annotation
Short name:
Guanosine monophosphate reductaseUniRule annotation
Gene namesi
Name:guaCUniRule annotation
Ordered Locus Names:Ent638_0649
OrganismiEnterobacter sp. (strain 638)
Taxonomic identifieri399742 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEnterobacter
ProteomesiUP000000230: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. GMP reductase complex Source: UniProtKB-EC
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 347347GMP reductasePRO_1000061237Add
BLAST

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi399742.Ent638_0649.

Structurei

3D structure databases

ProteinModelPortaliA4W6K6.
SMRiA4W6K6. Positions 3-338.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0516.
HOGENOMiHOG000165756.
KOiK00364.
OMAiCSCAGDV.
OrthoDBiEOG6GTZPV.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00596. GMP_reduct_type1.
InterProiIPR013785. Aldolase_TIM.
IPR005993. GuaC_type_1.
IPR015875. IMP_DH/GMP_Rdtase_CS.
IPR001093. IMP_DH_GMPRt.
[Graphical view]
PfamiPF00478. IMPDH. 1 hit.
[Graphical view]
PIRSFiPIRSF000235. GMP_reductase. 1 hit.
TIGRFAMsiTIGR01305. GMP_reduct_1. 1 hit.
PROSITEiPS00487. IMP_DH_GMP_RED. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4W6K6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRIEEDLKLG FKDVLIRPKR STLKSRSDVE LERQFTFKHS GQTWSGVPII
60 70 80 90 100
AANMDTVGTF AMATALASFD ILTAVHKHYS VEEWNAFAAS ASADVLKHVM
110 120 130 140 150
VSTGTSDTDF EKTKQILIAN PALNFLCIDV ANGYSEHFVQ FVSKAREAWP
160 170 180 190 200
DKTIIAGNVV TGEMCEELIL AGADIVKVGI GPGSVCTTRV KTGVGYPQLS
210 220 230 240 250
AVIECADAAH GLGGQIISDG GCTMPGDVAK AFGGGADFVM LGGMLAGHEE
260 270 280 290 300
SGGTVVEENG EKFMLFYGMS SESAMNRHVG GVAQYRAAEG KTVKLPLRGP
310 320 330 340
VENTARDVMG GLRSACTYVG ASRLKELTKR TTFIRVQEQE NRIFNSL
Length:347
Mass (Da):37,211
Last modified:May 29, 2007 - v1
Checksum:iD37597A3D7C86A9A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000653 Genomic DNA. Translation: ABP59336.1.
RefSeqiWP_012016057.1. NC_009436.1.
YP_001175387.1. NC_009436.1.

Genome annotation databases

EnsemblBacteriaiABP59336; ABP59336; Ent638_0649.
GeneIDi5113688.
KEGGient:Ent638_0649.
PATRICi20410844. VBIEntSp101211_0779.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000653 Genomic DNA. Translation: ABP59336.1 .
RefSeqi WP_012016057.1. NC_009436.1.
YP_001175387.1. NC_009436.1.

3D structure databases

ProteinModelPortali A4W6K6.
SMRi A4W6K6. Positions 3-338.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 399742.Ent638_0649.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABP59336 ; ABP59336 ; Ent638_0649 .
GeneIDi 5113688.
KEGGi ent:Ent638_0649.
PATRICi 20410844. VBIEntSp101211_0779.

Phylogenomic databases

eggNOGi COG0516.
HOGENOMi HOG000165756.
KOi K00364.
OMAi CSCAGDV.
OrthoDBi EOG6GTZPV.

Enzyme and pathway databases

BioCyci ESP399742:GJ0E-667-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_00596. GMP_reduct_type1.
InterProi IPR013785. Aldolase_TIM.
IPR005993. GuaC_type_1.
IPR015875. IMP_DH/GMP_Rdtase_CS.
IPR001093. IMP_DH_GMPRt.
[Graphical view ]
Pfami PF00478. IMPDH. 1 hit.
[Graphical view ]
PIRSFi PIRSF000235. GMP_reductase. 1 hit.
TIGRFAMsi TIGR01305. GMP_reduct_1. 1 hit.
PROSITEi PS00487. IMP_DH_GMP_RED. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the plant growth promoting endophytic bacterium Enterobacter sp. 638."
    Taghavi S., van der Lelie D., Hoffman A., Zhang Y.B., Walla M.D., Vangronsveld J., Newman L., Monchy S.
    PLoS Genet. 6:E1000943-E1000943(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 638.

Entry informationi

Entry nameiGUAC_ENT38
AccessioniPrimary (citable) accession number: A4W6K6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 29, 2007
Last modified: October 1, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3