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A4W418

- DEF_STRS2

UniProt

A4W418 - DEF_STRS2

Protein

Peptide deformylase

Gene

def

Organism
Streptococcus suis (strain 98HAH33)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (29 May 2007)
      Previous versions | rss
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    • Comment

    Functioni

    Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.UniRule annotation

    Catalytic activityi

    Formyl-L-methionyl peptide + H2O = formate + methionyl peptide.UniRule annotation

    Cofactori

    Binds 1 Fe2+ ion.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi131 – 1311IronUniRule annotation
    Metal bindingi174 – 1741IronUniRule annotation
    Active sitei175 – 1751UniRule annotation
    Metal bindingi178 – 1781IronUniRule annotation

    GO - Molecular functioni

    1. iron ion binding Source: InterPro
    2. peptide deformylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. translation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    BioCyciSSUI391296:GI2E-2005-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peptide deformylaseUniRule annotation (EC:3.5.1.88UniRule annotation)
    Short name:
    PDFUniRule annotation
    Alternative name(s):
    Polypeptide deformylaseUniRule annotation
    Gene namesi
    Name:defUniRule annotation
    Ordered Locus Names:SSU98_1949
    OrganismiStreptococcus suis (strain 98HAH33)
    Taxonomic identifieri391296 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000000244: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 204204Peptide deformylasePRO_0000301110Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi391296.SSU98_1949.

    Structurei

    3D structure databases

    ProteinModelPortaliA4W418.
    SMRiA4W418. Positions 2-204.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the polypeptide deformylase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0242.
    HOGENOMiHOG000243507.
    KOiK01462.
    OMAiHIDKENP.
    OrthoDBiEOG6PZXGQ.

    Family and domain databases

    Gene3Di3.90.45.10. 1 hit.
    HAMAPiMF_00163. Pep_deformylase.
    InterProiIPR000181. Fmet_deformylase.
    IPR023635. Peptide_deformylase.
    [Graphical view]
    PANTHERiPTHR10458. PTHR10458. 1 hit.
    PfamiPF01327. Pep_deformylase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF004749. Pep_def. 1 hit.
    PRINTSiPR01576. PDEFORMYLASE.
    SUPFAMiSSF56420. SSF56420. 1 hit.
    TIGRFAMsiTIGR00079. pept_deformyl. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A4W418-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSVIERLTKA AHLIDMDDII REGHPTLRQV AEEVAFPLSD QEIILGEKMM    50
    QFLKHSQDPV MAEKMKLRGG VGLAAPQIDV SKRIIAVLVP NPEDEEGNPP 100
    AQAYSLQEVL YNPKIVAHSV QEAAMEGGEG CLSVDREVQG YVVRHARVTV 150
    DYMDKNGEKH RIKLKGFNAI VVQHEIDHLN GVMFYDRIDP EHPFAVKEGM 200
    LVIE 204
    Length:204
    Mass (Da):22,856
    Last modified:May 29, 2007 - v1
    Checksum:iC5FDAAFB53363CEA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000408 Genomic DNA. Translation: ABP93107.1.
    RefSeqiYP_001201507.1. NC_009443.1.

    Genome annotation databases

    EnsemblBacteriaiABP93107; ABP93107; SSU98_1949.
    GeneIDi5102852.
    KEGGissv:SSU98_1949.
    PATRICi19780112. VBIStrSui72275_1913.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000408 Genomic DNA. Translation: ABP93107.1 .
    RefSeqi YP_001201507.1. NC_009443.1.

    3D structure databases

    ProteinModelPortali A4W418.
    SMRi A4W418. Positions 2-204.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 391296.SSU98_1949.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABP93107 ; ABP93107 ; SSU98_1949 .
    GeneIDi 5102852.
    KEGGi ssv:SSU98_1949.
    PATRICi 19780112. VBIStrSui72275_1913.

    Phylogenomic databases

    eggNOGi COG0242.
    HOGENOMi HOG000243507.
    KOi K01462.
    OMAi HIDKENP.
    OrthoDBi EOG6PZXGQ.

    Enzyme and pathway databases

    BioCyci SSUI391296:GI2E-2005-MONOMER.

    Family and domain databases

    Gene3Di 3.90.45.10. 1 hit.
    HAMAPi MF_00163. Pep_deformylase.
    InterProi IPR000181. Fmet_deformylase.
    IPR023635. Peptide_deformylase.
    [Graphical view ]
    PANTHERi PTHR10458. PTHR10458. 1 hit.
    Pfami PF01327. Pep_deformylase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF004749. Pep_def. 1 hit.
    PRINTSi PR01576. PDEFORMYLASE.
    SUPFAMi SSF56420. SSF56420. 1 hit.
    TIGRFAMsi TIGR00079. pept_deformyl. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "A glimpse of streptococcal toxic shock syndrome from comparative genomics of S. suis 2 Chinese isolates."
      Chen C., Tang J., Dong W., Wang C., Feng Y., Wang J., Zheng F., Pan X., Liu D., Li M., Song Y., Zhu X., Sun H., Feng T., Guo Z., Ju A., Ge J., Dong Y.
      , Sun W., Jiang Y., Wang J., Yan J., Yang H., Wang X., Gao G.F., Yang R., Wang J., Yu J.
      PLoS ONE 2:E315-E315(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 98HAH33.

    Entry informationi

    Entry nameiDEF_STRS2
    AccessioniPrimary (citable) accession number: A4W418
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: May 29, 2007
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3