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A4W3V8

- ILVC_STRS2

UniProt

A4W3V8 - ILVC_STRS2

Protein

Ketol-acid reductoisomerase

Gene

ilvC

Organism
Streptococcus suis (strain 98HAH33)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 56 (01 Oct 2014)
      Sequence version 1 (29 May 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    (R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH.UniRule annotation
    (2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP+ = (S)-2-hydroxy-2-ethyl-3-oxobutanoate + NADPH.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei108 – 1081UniRule annotation

    GO - Molecular functioni

    1. coenzyme binding Source: InterPro
    2. ketol-acid reductoisomerase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. isoleucine biosynthetic process Source: UniProtKB-HAMAP
    2. valine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Branched-chain amino acid biosynthesis

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    BioCyciSSUI391296:GI2E-1945-MONOMER.
    UniPathwayiUPA00047; UER00056.
    UPA00049; UER00060.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ketol-acid reductoisomeraseUniRule annotation (EC:1.1.1.86UniRule annotation)
    Alternative name(s):
    Acetohydroxy-acid isomeroreductaseUniRule annotation
    Alpha-keto-beta-hydroxylacyl reductoisomeraseUniRule annotation
    Gene namesi
    Name:ilvCUniRule annotation
    Ordered Locus Names:SSU98_1889
    OrganismiStreptococcus suis (strain 98HAH33)
    Taxonomic identifieri391296 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000000244: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 340340Ketol-acid reductoisomerasePRO_1000050579Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi391296.SSU98_1889.

    Structurei

    3D structure databases

    ProteinModelPortaliA4W3V8.
    SMRiA4W3V8. Positions 4-328.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ketol-acid reductoisomerase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0059.
    HOGENOMiHOG000016230.
    KOiK00053.
    OMAiRFAKDFI.
    OrthoDBiEOG625K07.

    Family and domain databases

    Gene3Di1.10.1040.10. 1 hit.
    HAMAPiMF_00435. IlvC.
    InterProiIPR008927. 6-PGluconate_DH_C-like.
    IPR013023. AcH_isomrdctse.
    IPR000506. AcH_isomrdctse_C.
    IPR013328. DH_multihelical.
    IPR013116. IlvN.
    [Graphical view]
    PANTHERiPTHR21371. PTHR21371. 1 hit.
    PfamiPF01450. IlvC. 1 hit.
    PF07991. IlvN. 1 hit.
    [Graphical view]
    SUPFAMiSSF48179. SSF48179. 1 hit.
    TIGRFAMsiTIGR00465. ilvC. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A4W3V8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTVTMQYEKD VTVAALDGKR IAVIGYGSQG HAHAQNLRDT GHDVIIGVRA    50
    GKSFDKAKED GFETFEVAEA AKQADVIMIL APDEIQADLY NEEIAPNLEA 100
    GNALGFAHGF NVHFEFIKVP ADVDVFMCAP KGPGHLVRRT FEEGFGVPAL 150
    YAVYQDATGN AKHIAMDWAK GVGSARVGLL ETTFKEETEE DLFGEQAVLC 200
    GGLTALMQAG FEVLTEAGYA PELAYFEVLH EMKLIVDLVY EGGFKKMRQS 250
    ISNTAEFGDY VSGPRVITDQ VKENMKAVLA DIQSGKFAND FVNDYKAGRP 300
    RMEAYRKEAE NLEIEKVGAE LRKAMPFVGR NDDDAFKIYN 340
    Length:340
    Mass (Da):37,356
    Last modified:May 29, 2007 - v1
    Checksum:i6BC139BF65F109C6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000408 Genomic DNA. Translation: ABP93047.1.
    RefSeqiYP_001201447.1. NC_009443.1.

    Genome annotation databases

    EnsemblBacteriaiABP93047; ABP93047; SSU98_1889.
    GeneIDi5101928.
    KEGGissv:SSU98_1889.
    PATRICi19779996. VBIStrSui72275_1855.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000408 Genomic DNA. Translation: ABP93047.1 .
    RefSeqi YP_001201447.1. NC_009443.1.

    3D structure databases

    ProteinModelPortali A4W3V8.
    SMRi A4W3V8. Positions 4-328.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 391296.SSU98_1889.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABP93047 ; ABP93047 ; SSU98_1889 .
    GeneIDi 5101928.
    KEGGi ssv:SSU98_1889.
    PATRICi 19779996. VBIStrSui72275_1855.

    Phylogenomic databases

    eggNOGi COG0059.
    HOGENOMi HOG000016230.
    KOi K00053.
    OMAi RFAKDFI.
    OrthoDBi EOG625K07.

    Enzyme and pathway databases

    UniPathwayi UPA00047 ; UER00056 .
    UPA00049 ; UER00060 .
    BioCyci SSUI391296:GI2E-1945-MONOMER.

    Family and domain databases

    Gene3Di 1.10.1040.10. 1 hit.
    HAMAPi MF_00435. IlvC.
    InterProi IPR008927. 6-PGluconate_DH_C-like.
    IPR013023. AcH_isomrdctse.
    IPR000506. AcH_isomrdctse_C.
    IPR013328. DH_multihelical.
    IPR013116. IlvN.
    [Graphical view ]
    PANTHERi PTHR21371. PTHR21371. 1 hit.
    Pfami PF01450. IlvC. 1 hit.
    PF07991. IlvN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48179. SSF48179. 1 hit.
    TIGRFAMsi TIGR00465. ilvC. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "A glimpse of streptococcal toxic shock syndrome from comparative genomics of S. suis 2 Chinese isolates."
      Chen C., Tang J., Dong W., Wang C., Feng Y., Wang J., Zheng F., Pan X., Liu D., Li M., Song Y., Zhu X., Sun H., Feng T., Guo Z., Ju A., Ge J., Dong Y.
      , Sun W., Jiang Y., Wang J., Yan J., Yang H., Wang X., Gao G.F., Yang R., Wang J., Yu J.
      PLoS ONE 2:E315-E315(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 98HAH33.

    Entry informationi

    Entry nameiILVC_STRS2
    AccessioniPrimary (citable) accession number: A4W3V8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: May 29, 2007
    Last modified: October 1, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3