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A4W3V2 (UPPP_STRS2) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Ordered Locus Names:SSU98_1883
OrganismStreptococcus suis (strain 98HAH33) [Complete proteome] [HAMAP]
Taxonomic identifier391296 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Protein attributes

Sequence length278 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 278278Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_0000303036

Regions

Transmembrane44 – 6421Helical; Potential
Transmembrane84 – 10421Helical; Potential
Transmembrane112 – 13221Helical; Potential
Transmembrane187 – 20721Helical; Potential
Transmembrane224 – 24421Helical; Potential
Transmembrane254 – 27421Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
A4W3V2 [UniParc].

Last modified May 29, 2007. Version 1.
Checksum: 8E54725F252023F3

FASTA27831,191
        10         20         30         40         50         60 
MLLELLKAIF LGIIEGVTEW LPVSSTGHLI LVQEFVKLNQ SKNFLEMFNI VIQLGAILAV 

        70         80         90        100        110        120 
MTIYFKKLNP FQPGKTKRDI QLTWQLWAKV VIACIPSILI AVPLDNWFEA HFNFMVPIAI 

       130        140        150        160        170        180 
ALIVYGIAFI WIENRNRGIE PQVTDLAKMS YKTALLIGCF QVLSIVPGTS RSGATILGAI 

       190        200        210        220        230        240 
ILGTSRSVAA DFTFFLGIPT MFGYSGLKAV KYFLDGNSLN MEQVWILLVA SVTAYLVSLV 

       250        260        270 
VIRFLTDFVK KHDFTVFGYY RIILGAILLV YAFITFLF 

« Hide

References

[1]"A glimpse of streptococcal toxic shock syndrome from comparative genomics of S. suis 2 Chinese isolates."
Chen C., Tang J., Dong W., Wang C., Feng Y., Wang J., Zheng F., Pan X., Liu D., Li M., Song Y., Zhu X., Sun H., Feng T., Guo Z., Ju A., Ge J., Dong Y. expand/collapse author list , Sun W., Jiang Y., Wang J., Yan J., Yang H., Wang X., Gao G.F., Yang R., Wang J., Yu J.
PLoS ONE 2:E315-E315(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 98HAH33.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000408 Genomic DNA. Translation: ABP93041.1.
RefSeqYP_001201441.1. NC_009443.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING391296.SSU98_1883.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABP93041; ABP93041; SSU98_1883.
GeneID5101922.
KEGGssv:SSU98_1883.
PATRIC19779984. VBIStrSui72275_1849.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218356.
KOK06153.
OMAAQCFALI.
OrthoDBEOG6QP13M.
ProtClustDBPRK00281.

Enzyme and pathway databases

BioCycSSUI391296:GI2E-1939-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUPPP_STRS2
AccessionPrimary (citable) accession number: A4W3V2
Entry history
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: May 29, 2007
Last modified: February 19, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families