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A4W2D6 (A4W2D6_STRS2) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047
Ordered Locus Names:SSU98_1367 EMBL ABP92525.1
OrganismStreptococcus suis (strain 98HAH33) [Complete proteome] [HAMAP] EMBL ABP92525.1
Taxonomic identifier391296 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Protein attributes

Sequence length283 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS005905

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS005905

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS005905.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS005905

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain67 – 269203ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding97 – 15256ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding2231Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2361Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2361Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding2381Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
A4W2D6 [UniParc].

Last modified May 29, 2007. Version 1.
Checksum: 85BF44866E8C8E83

FASTA28331,420
        10         20         30         40         50         60 
MTNATIVEEQ KIRPSDIYEE KAVVFPVLHG PMGEDGSIQG FLEVLRMPYV GTNILSSSVA 

        70         80         90        100        110        120 
MDKITTKRVL ESAGISQVPY VAVIEGENID DKIAEIEGKL TYPVFVKPAN MGSSVGISKA 

       130        140        150        160        170        180 
EDLAGLRKAL DLAFKYDSRV LVEQGVNARE IEVGLLGNAD VKTTLPGEVV KDVAFYDYDA 

       190        200        210        220        230        240 
KYIDNKITME IPAKIDESIM DIMRDNAAKA FRAIGGCGLS RCDFFLTEDG DIFLNELNTM 

       250        260        270        280 
PGFTQWSMYP LLWDNMGLAY PDLIEELVRL AKEMFEKRES HLI 

« Hide

References

[1]"A glimpse of streptococcal toxic shock syndrome from comparative genomics of S. suis 2 Chinese isolates."
BGI
Chen C., Tang J., Dong W., Wang C., Feng Y., Wang J., Zheng F., Pan X., Liu D., Li M., Song Y., Zhu X., Sun H., Feng T., Guo Z., Ju A., Ge J., Dong Y. expand/collapse author list , Sun W., Jiang Y., Wang J., Yan J., Yang H., Wang X., Gao G.F., Yang R., Wang J., Yu J.
PLoS ONE 2:E315-E315(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 98HAH33 EMBL ABP92525.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000408 Genomic DNA. Translation: ABP92525.1.
RefSeqYP_001200925.1. NC_009443.1.

3D structure databases

ProteinModelPortalA4W2D6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING391296.SSU98_1367.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABP92525; ABP92525; SSU98_1367.
GeneID5101387.
KEGGssv:SSU98_1367.
PATRIC19778946. VBIStrSui72275_1333.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1181.
HOGENOMHOG000011593.
KOK01921.
OMAMDKIAMK.
OrthoDBEOG64BQ73.

Enzyme and pathway databases

BioCycSSUI391296:GI2E-1420-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA4W2D6_STRS2
AccessionPrimary (citable) accession number: A4W2D6
Entry history
Integrated into UniProtKB/TrEMBL: May 29, 2007
Last sequence update: May 29, 2007
Last modified: February 19, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)