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Protein

UvrABC system protein B

Gene

uvrB

Organism
Streptococcus suis (strain 98HAH33)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA2B2 complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi44 – 51ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionExcision nuclease, Helicase, Hydrolase
Biological processDNA damage, DNA excision, DNA repair, SOS response
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
UvrABC system protein BUniRule annotation
Short name:
Protein UvrBUniRule annotation
Alternative name(s):
Excinuclease ABC subunit BUniRule annotation
Gene namesi
Name:uvrBUniRule annotation
Ordered Locus Names:SSU98_1038
OrganismiStreptococcus suis (strain 98HAH33)
Taxonomic identifieri391296 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Subcellular locationi

A4W1F7:
  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000779311 – 661UvrABC system protein BAdd BLAST661

Interactioni

Subunit structurei

Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA4W1F7.
SMRiA4W1F7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 186Helicase ATP-bindingUniRule annotationAdd BLAST156
Domaini435 – 601Helicase C-terminalUniRule annotationAdd BLAST167
Domaini626 – 661UVRUniRule annotationAdd BLAST36

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi97 – 120Beta-hairpinAdd BLAST24

Domaini

The beta-hairpin motif is involved in DNA binding.UniRule annotation

Sequence similaritiesi

Belongs to the UvrB family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000073580.
KOiK03702.
OMAiRYMHSEI.

Family and domain databases

CDDicd00079. HELICc. 1 hit.
Gene3Di4.10.860.10. 1 hit.
HAMAPiMF_00204. UvrB. 1 hit.
InterProiView protein in InterPro
IPR006935. Helicase/UvrB_N.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR001943. UVR_dom.
IPR036876. UVR_dom_sf.
IPR004807. UvrB.
IPR024759. UvrB_YAD/RRR_dom.
PANTHERiPTHR24029. PTHR24029. 1 hit.
PfamiView protein in Pfam
PF00271. Helicase_C. 1 hit.
PF04851. ResIII. 1 hit.
PF02151. UVR. 1 hit.
PF12344. UvrB. 1 hit.
SMARTiView protein in SMART
SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
SUPFAMiSSF46600. SSF46600. 1 hit.
SSF52540. SSF52540. 2 hits.
TIGRFAMsiTIGR00631. uvrb. 1 hit.
PROSITEiView protein in PROSITE
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS50151. UVR. 1 hit.

Sequencei

Sequence statusi: Complete.

A4W1F7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MINRNTENQF KLVSKYAPSG DQPQAIETLV DNIEGGEKAQ ILMGATGTGK
60 70 80 90 100
TYTMSQVIAR VNKPTLVIAH NKTLAGQLYS EFKEFFPENA VEYFVSYYDY
110 120 130 140 150
YQPEAYVPSS DTYIEKDSSV NDEIDKLRHS ATSALLERND VIVVASVSCI
160 170 180 190 200
YGLGSPKEYS DSVVSLRPGQ EISRDQLLNA LVDIQFERND IDFQRGRFRV
210 220 230 240 250
RGDVVEIFPA SRDEHAFRVE FFGDEIDRIR EIESLTGKVL GDVDHLAIFP
260 270 280 290 300
ATHFVTNDDH METAIAKIQA ELEEQLKVFE AEGKLLEAQR LKQRTDYDIE
310 320 330 340 350
MLREMGYTNG VENYSRHMDG RSEGEPPYTL LDFFPEDYLI MIDESHMTMG
360 370 380 390 400
QIKGMYNGDR SRKEMLVNYG FRLPSALDNR PLRREEFESH VHQIVYVSAT
410 420 430 440 450
PGDYEMEQTE TVVEQIIRPT GLLDPEVEVR PTMGQMDDLL GEINARVEKG
460 470 480 490 500
ERTFITTLTK KMAEDLTDYL KEMGVKVKYM HSDIKTLERT EIIRDLRLGV
510 520 530 540 550
FDVLIGINLL REGIDVPEVS LVAILDADKE GFLRNERGLI QTIGRAARNS
560 570 580 590 600
EGHVIMYADK VTESMRKAME ETARRRQIQM AYNEEHGIIP QTIKKEIRDL
610 620 630 640 650
ISVTKAVTQD KEEVVDFNAL NKDERKAMIK KLEGQMQEAA EVLDFELAAQ
660
IRDMVIELKN M
Length:661
Mass (Da):75,593
Last modified:May 29, 2007 - v1
Checksum:iC09DDA972AF99992
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000408 Genomic DNA. Translation: ABP92196.1.

Genome annotation databases

EnsemblBacteriaiABP92196; ABP92196; SSU98_1038.
KEGGissv:SSU98_1038.

Similar proteinsi

Entry informationi

Entry nameiUVRB_STRS2
AccessioniPrimary (citable) accession number: A4W1F7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 29, 2007
Last modified: October 25, 2017
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families