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A4W0V3

- TYSY_STRS2

UniProt

A4W0V3 - TYSY_STRS2

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Protein
Thymidylate synthase
Gene
thyA, SSU98_0834
Organism
Streptococcus suis (strain 98HAH33)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Provides the sole de novo source of dTMP for DNA biosynthesis By similarity.UniRule annotation

Catalytic activityi

5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei154 – 1541 By similarity

GO - Molecular functioni

  1. thymidylate synthase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. dTMP biosynthetic process Source: UniProtKB-HAMAP
  2. dTTP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Nucleotide biosynthesis

Enzyme and pathway databases

BioCyciSSUI391296:GI2E-887-MONOMER.
UniPathwayiUPA00575.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidylate synthase (EC:2.1.1.45)
Short name:
TS
Short name:
TSase
Gene namesi
Name:thyA
Ordered Locus Names:SSU98_0834
OrganismiStreptococcus suis (strain 98HAH33)
Taxonomic identifieri391296 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000000244: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 279279Thymidylate synthaseUniRule annotation
PRO_1000000694Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi391296.SSU98_0834.

Structurei

3D structure databases

ProteinModelPortaliA4W0V3.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0207.
HOGENOMiHOG000257898.
KOiK00560.
OMAiELLWIYQ.
OrthoDBiEOG6K6V53.

Family and domain databases

Gene3Di3.30.572.10. 1 hit.
HAMAPiMF_00008. Thymidy_synth_bact.
InterProiIPR023451. Thymidate_synth/dCMP_Mease.
IPR000398. Thymidylate_synthase.
IPR020940. Thymidylate_synthase_AS.
[Graphical view]
PfamiPF00303. Thymidylat_synt. 1 hit.
[Graphical view]
PRINTSiPR00108. THYMDSNTHASE.
SUPFAMiSSF55831. SSF55831. 1 hit.
PROSITEiPS00091. THYMIDYLATE_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4W0V3-1 [UniParc]FASTAAdd to Basket

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MTKADIIFKE NIRKIMEEGV FSENARPRYK DGNVANSKYV TGAFAEYDLS    50
KGEFPITTLR PIPIKSAIKE ILWIYQDQTN DLSVLQEKYG VQYWNDWEVE 100
GTGTIGERYG AIVKKHDIIS KILKQLEENP WNRRNVISLW DYEAFDQSAG 150
LLPCAFQTLF DVRRVDGEIY LDATLTQRSN DMLVAHHINA MQYVALQMMI 200
AKHFGWKVGK FFYFINNLHI YDNQFEQAEE LLRRTPSEVE PRLVLNVPDG 250
TNFFDIRAED FELVDYNPVK PQLKFDLAI 279
Length:279
Mass (Da):32,534
Last modified:May 29, 2007 - v1
Checksum:i24D235E220A7DE91
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000408 Genomic DNA. Translation: ABP91992.1.
RefSeqiYP_001200392.1. NC_009443.1.

Genome annotation databases

EnsemblBacteriaiABP91992; ABP91992; SSU98_0834.
GeneIDi5101300.
KEGGissv:SSU98_0834.
PATRICi19777909. VBIStrSui72275_0817.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000408 Genomic DNA. Translation: ABP91992.1 .
RefSeqi YP_001200392.1. NC_009443.1.

3D structure databases

ProteinModelPortali A4W0V3.
ModBasei Search...

Protein-protein interaction databases

STRINGi 391296.SSU98_0834.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABP91992 ; ABP91992 ; SSU98_0834 .
GeneIDi 5101300.
KEGGi ssv:SSU98_0834.
PATRICi 19777909. VBIStrSui72275_0817.

Phylogenomic databases

eggNOGi COG0207.
HOGENOMi HOG000257898.
KOi K00560.
OMAi ELLWIYQ.
OrthoDBi EOG6K6V53.

Enzyme and pathway databases

UniPathwayi UPA00575 .
BioCyci SSUI391296:GI2E-887-MONOMER.

Family and domain databases

Gene3Di 3.30.572.10. 1 hit.
HAMAPi MF_00008. Thymidy_synth_bact.
InterProi IPR023451. Thymidate_synth/dCMP_Mease.
IPR000398. Thymidylate_synthase.
IPR020940. Thymidylate_synthase_AS.
[Graphical view ]
Pfami PF00303. Thymidylat_synt. 1 hit.
[Graphical view ]
PRINTSi PR00108. THYMDSNTHASE.
SUPFAMi SSF55831. SSF55831. 1 hit.
PROSITEi PS00091. THYMIDYLATE_SYNTHASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A glimpse of streptococcal toxic shock syndrome from comparative genomics of S. suis 2 Chinese isolates."
    Chen C., Tang J., Dong W., Wang C., Feng Y., Wang J., Zheng F., Pan X., Liu D., Li M., Song Y., Zhu X., Sun H., Feng T., Guo Z., Ju A., Ge J., Dong Y.
    , Sun W., Jiang Y., Wang J., Yan J., Yang H., Wang X., Gao G.F., Yang R., Wang J., Yu J.
    PLoS ONE 2:E315-E315(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 98HAH33.

Entry informationi

Entry nameiTYSY_STRS2
AccessioniPrimary (citable) accession number: A4W0V3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 29, 2007
Last modified: May 14, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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