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A4W0S2 (KHSE_STRS2) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Homoserine kinase
Short name=HK
Short name=HSK
EC=2.7.1.39
Gene names
Name:thrB
Ordered Locus Names:SSU98_0803
OrganismStreptococcus suis (strain 98HAH33) [Complete proteome] [HAMAP]
Taxonomic identifier391296 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length286 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate By similarity. HAMAP MF_00384

Catalytic activity

ATP + L-homoserine = ADP + O-phospho-L-homoserine. HAMAP MF_00384

Pathway

Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5. HAMAP MF_00384

Subcellular location

Cytoplasm Potential HAMAP MF_00384.

Sequence similarities

Belongs to the GHMP kinase family. Homoserine kinase subfamily.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Threonine biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processthreonine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

homoserine kinase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 286286Homoserine kinase HAMAP MF_00384
PRO_1000049175

Regions

Nucleotide binding78 – 8811ATP Potential

Sequences

Sequence LengthMass (Da)Tools
A4W0S2 [UniParc].

Last modified May 29, 2007. Version 1.
Checksum: 00D2E4EB10C1932D

FASTA28630,782
        10         20         30         40         50         60 
MKIIIPATSA NIGPGFDSVG VALSKYLTIE VFEETDEWVI EHNLEHVPSD KNNLLIKTAL 

        70         80         90        100        110        120 
KIEKGLQPHR IRMISDIPLA RGLGSSSSVI VAGIELANQL AGLNMTADEK LLKATEIEGH 

       130        140        150        160        170        180 
PDNVAPAIFG NLVISSYVNK RVQAVVTEFP EASFVAFIPN YPLRTVESRG VLPSQMGYKK 

       190        200        210        220        230        240 
AVAASAIANV AVASLMAGDL EKAGKAIQSD MFHEPFRQLL VKEFCPIKQT AQELGAYATY 

       250        260        270        280 
LSGAGPTVMV LAPKDREDAI VLALEELNLD GTVHRLQVDT KGIAIV

« Hide

References

[1]"A glimpse of streptococcal toxic shock syndrome from comparative genomics of S. suis 2 Chinese isolates."
Chen C., Tang J., Dong W., Wang C., Feng Y., Wang J., Zheng F., Pan X., Liu D., Li M., Song Y., Zhu X., Sun H., Feng T., Guo Z., Ju A., Ge J., Dong Y. expand/collapse author list , Sun W., Jiang Y., Wang J., Yan J., Yang H., Wang X., Gao G.F., Yang R., Wang J., Yu J.
PLoS ONE 2:E315-E315(2007) [PubMed: 17375201] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 98HAH33.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000408 Genomic DNA. Translation: ABP91961.1.
RefSeqYP_001200361.1. NC_009443.1.

3D structure databases

ProteinModelPortalA4W0S2.
ModBaseSearch...

Protein-protein interaction databases

STRINGA4W0S2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBSTRT00000056935; EBSTRP00000053050; EBSTRG00000056925.
GeneID5102305.
GenomeReviewsGene locus SSU98_0803 in contig CP000408_GR.
KEGGssv:SSU98_0803.
PATRIC19777848. VBIStrSui72275_0787.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0083.
GeneTreeEBGT00050000027810.
HOGENOMHBG646290.
OMANNALMST.
PhylomeDBA4W0S2.
ProtClustDBPRK01212.

Enzyme and pathway databases

BioCycSSUI391296:SSU98_0803-MONOMER.

Family and domain databases

HAMAPMF_00384. Homoser_kinase.
[Tree]
InterProIPR006204. GHMP_kinase.
IPR013750. GHMP_kinase_C.
IPR006203. GHMP_knse_ATP-bd_CS.
IPR000870. Homoserine_kinase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
Gene3DG3DSA:3.30.230.10. Ribosomal_S5_D2-type_fold. 1 hit.
KOK00872.
PfamPF08544. GHMP_kinases_C. 1 hit.
PF00288. GHMP_kinases_N. 1 hit.
[Graphical view]
PIRSFPIRSF000676. Homoser_kin. 1 hit.
PRINTSPR00958. HOMSERKINASE.
SUPFAMSSF54211. Ribosomal_S5_D2-typ_fold. 1 hit.
TIGRFAMsTIGR00191. ThrB. 1 hit.
PROSITEPS00627. GHMP_KINASES_ATP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKHSE_STRS2
AccessionPrimary (citable) accession number: A4W0S2
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 29, 2007
Last modified: December 14, 2011
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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