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A4W0K2

- THIM_STRS2

UniProt

A4W0K2 - THIM_STRS2

Protein

Hydroxyethylthiazole kinase

Gene

thiM

Organism
Streptococcus suis (strain 98HAH33)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (29 May 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).UniRule annotation

    Catalytic activityi

    ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei38 – 381Substrate; via amide nitrogenUniRule annotation
    Binding sitei114 – 1141ATPUniRule annotation
    Binding sitei159 – 1591ATPUniRule annotation
    Binding sitei186 – 1861Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. hydroxyethylthiazole kinase activity Source: UniProtKB-HAMAP
    3. magnesium ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. thiamine biosynthetic process Source: UniProtKB-KW
    2. thiamine diphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Thiamine biosynthesis

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSSUI391296:GI2E-783-MONOMER.
    UniPathwayiUPA00060; UER00139.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hydroxyethylthiazole kinaseUniRule annotation (EC:2.7.1.50UniRule annotation)
    Alternative name(s):
    4-methyl-5-beta-hydroxyethylthiazole kinaseUniRule annotation
    Short name:
    TH kinaseUniRule annotation
    Short name:
    Thz kinaseUniRule annotation
    Gene namesi
    Name:thiMUniRule annotation
    Ordered Locus Names:SSU98_0733
    OrganismiStreptococcus suis (strain 98HAH33)
    Taxonomic identifieri391296 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000000244: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 236236Hydroxyethylthiazole kinasePRO_0000383908Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi391296.SSU98_0733.

    Structurei

    3D structure databases

    ProteinModelPortaliA4W0K2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Thz kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2145.
    HOGENOMiHOG000114352.
    KOiK00878.
    OMAiNACTQLA.
    OrthoDBiEOG628F8M.

    Family and domain databases

    Gene3Di3.40.1190.20. 1 hit.
    HAMAPiMF_00228. Thz_kinase.
    InterProiIPR000417. Hyethyz_kinase.
    IPR029056. Ribokinase-like.
    [Graphical view]
    PfamiPF02110. HK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000513. Thz_kinase. 1 hit.
    PRINTSiPR01099. HYETHTZKNASE.
    SUPFAMiSSF53613. SSF53613. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A4W0K2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYLEKLRSQN PLTICITNDV VKNFTANGLL ALGASPAMSE YPEDLEDLLP    50
    YTKGLLINTG TLTNETWELY KSALDIAEKY GVPTVLDPVA AGAGAYRKKV 100
    TLDLLHHHTI SLVRGNAGEI AALIGESIET KGVDSAQIDN VGELALRANQ 150
    QLGIPVVITG KKDAVAVNHQ VRILENGSEL MPLVTGTGCL LGAVLAAFIH 200
    LADEDHYWIV WKSPIGLFDR WRNGRAENLT TRNLPD 236
    Length:236
    Mass (Da):25,622
    Last modified:May 29, 2007 - v1
    Checksum:i0B2E9CDDA0CC771E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000408 Genomic DNA. Translation: ABP91891.1.
    RefSeqiWP_011922790.1. NC_009443.1.
    YP_001200291.1. NC_009443.1.

    Genome annotation databases

    EnsemblBacteriaiABP91891; ABP91891; SSU98_0733.
    GeneIDi5101883.
    KEGGissv:SSU98_0733.
    PATRICi19777705. VBIStrSui72275_0720.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000408 Genomic DNA. Translation: ABP91891.1 .
    RefSeqi WP_011922790.1. NC_009443.1.
    YP_001200291.1. NC_009443.1.

    3D structure databases

    ProteinModelPortali A4W0K2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 391296.SSU98_0733.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABP91891 ; ABP91891 ; SSU98_0733 .
    GeneIDi 5101883.
    KEGGi ssv:SSU98_0733.
    PATRICi 19777705. VBIStrSui72275_0720.

    Phylogenomic databases

    eggNOGi COG2145.
    HOGENOMi HOG000114352.
    KOi K00878.
    OMAi NACTQLA.
    OrthoDBi EOG628F8M.

    Enzyme and pathway databases

    UniPathwayi UPA00060 ; UER00139 .
    BioCyci SSUI391296:GI2E-783-MONOMER.

    Family and domain databases

    Gene3Di 3.40.1190.20. 1 hit.
    HAMAPi MF_00228. Thz_kinase.
    InterProi IPR000417. Hyethyz_kinase.
    IPR029056. Ribokinase-like.
    [Graphical view ]
    Pfami PF02110. HK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000513. Thz_kinase. 1 hit.
    PRINTSi PR01099. HYETHTZKNASE.
    SUPFAMi SSF53613. SSF53613. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "A glimpse of streptococcal toxic shock syndrome from comparative genomics of S. suis 2 Chinese isolates."
      Chen C., Tang J., Dong W., Wang C., Feng Y., Wang J., Zheng F., Pan X., Liu D., Li M., Song Y., Zhu X., Sun H., Feng T., Guo Z., Ju A., Ge J., Dong Y.
      , Sun W., Jiang Y., Wang J., Yan J., Yang H., Wang X., Gao G.F., Yang R., Wang J., Yu J.
      PLoS ONE 2:E315-E315(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 98HAH33.

    Entry informationi

    Entry nameiTHIM_STRS2
    AccessioniPrimary (citable) accession number: A4W0K2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: May 29, 2007
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3