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A4W0G0

- FTHS_STRS2

UniProt

A4W0G0 - FTHS_STRS2

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Streptococcus suis (strain 98HAH33)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (29 May 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi65 – 728ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSSUI391296:GI2E-741-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:SSU98_0691
    OrganismiStreptococcus suis (strain 98HAH33)
    Taxonomic identifieri391296 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000000244: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 556556Formate--tetrahydrofolate ligasePRO_0000300549Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi391296.SSU98_0691.

    Structurei

    3D structure databases

    ProteinModelPortaliA4W0G0.
    SMRiA4W0G0. Positions 4-554.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiLKHHGGV.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A4W0G0-1 [UniParc]FASTAAdd to Basket

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    MKTDIDIAQS ITLKPITEIV EKVGISFDDI ELYGKYKAKL SFDKINAVKD    50
    NAPGKLILVT AINPTPAGEG KSTITIGLAD ALSKIGKKTM IALREPSLGP 100
    VMGIKGGAAG GGYAQVLPME DINLHFTGDM HAITTANNAL SALIDNHIHQ 150
    GNVIGIDQRR IIWKRVVDLN DRALRKVTVG LGGPLNGIPR EDGFDITVAS 200
    EIMAILCLAT DINDLKERLA NIVIGYRFDC SPVYVRDLAV EGALTLILKD 250
    AIKPNLVQTI YGTPAFVHGG PFANIAHGCN SVLATTTALR LADYTVTEAG 300
    FGADLGAEKF LDIKVPNLPK APDAVVIVAT LRALKMHGGV AKTELSAENV 350
    EAVKAGFSNL KRHVENIRKY GIPAVVAINE FVSDTAAEIA VLKELCAAIG 400
    VPVELASVWA NGADGGVELA ETVVATIDNQ AASYQRLYKS EDSLEEKVTK 450
    IVTQIYGGTG VVFEKKARNQ LTEFAKNGWD KLPVCMAKTQ YSFSDDQFAL 500
    GAPTDFDITV REFVPKLGAG FIVALTGDVM TMPGLPKAPV ALNMDVAADG 550
    TAIGLF 556
    Length:556
    Mass (Da):59,108
    Last modified:May 29, 2007 - v1
    Checksum:i6CC2ED05FD864616
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000408 Genomic DNA. Translation: ABP91849.1.
    RefSeqiYP_001200249.1. NC_009443.1.

    Genome annotation databases

    EnsemblBacteriaiABP91849; ABP91849; SSU98_0691.
    GeneIDi5101262.
    KEGGissv:SSU98_0691.
    PATRICi19777621. VBIStrSui72275_0679.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000408 Genomic DNA. Translation: ABP91849.1 .
    RefSeqi YP_001200249.1. NC_009443.1.

    3D structure databases

    ProteinModelPortali A4W0G0.
    SMRi A4W0G0. Positions 4-554.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 391296.SSU98_0691.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABP91849 ; ABP91849 ; SSU98_0691 .
    GeneIDi 5101262.
    KEGGi ssv:SSU98_0691.
    PATRICi 19777621. VBIStrSui72275_0679.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi LKHHGGV.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci SSUI391296:GI2E-741-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A glimpse of streptococcal toxic shock syndrome from comparative genomics of S. suis 2 Chinese isolates."
      Chen C., Tang J., Dong W., Wang C., Feng Y., Wang J., Zheng F., Pan X., Liu D., Li M., Song Y., Zhu X., Sun H., Feng T., Guo Z., Ju A., Ge J., Dong Y.
      , Sun W., Jiang Y., Wang J., Yan J., Yang H., Wang X., Gao G.F., Yang R., Wang J., Yu J.
      PLoS ONE 2:E315-E315(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 98HAH33.

    Entry informationi

    Entry nameiFTHS_STRS2
    AccessioniPrimary (citable) accession number: A4W0G0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: May 29, 2007
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3