A4VXW3 (FENR_STRSY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ferredoxin--NADP reductase
Short name=FNR
Short name=Fd-NADP(+) reductase
EC=1.18.1.2

Gene names

Ordered Locus Names:

SSU05_1986

Organism

Streptococcus suis (strain 05ZYH33) [Complete proteome] [HAMAP]

Taxonomic identifier

391295 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Streptococcus › Streptococcus suis

Protein attributes

Sequence length	322 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	2 reduced ferredoxin + NADP+ + H+ = 2 oxidized ferredoxin + NADPH. HAMAP-Rule MF_01685
Cofactor	Binds 1 FAD per subunit By similarity.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the ferredoxin--NADP reductase type 2 family.

Ontologies

Keywords
Ligand	FAD Flavoprotein NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular_function	NADP binding Inferred from electronic annotation. Source: HAMAP ferredoxin-NADP+ reductase activity Inferred from electronic annotation. Source: HAMAP flavin adenine dinucleotide binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 322	322	Ferredoxin--NADP reductase HAMAP-Rule MF_01685		PRO_0000364974
Sites
	Binding site	34	1	FAD By similarity
	Binding site	42	1	FAD By similarity
	Binding site	47	1	FAD By similarity
	Binding site	87	1	FAD; via amide nitrogen and carbonyl oxygen By similarity
	Binding site	119	1	FAD; via amide nitrogen By similarity
	Binding site	279	1	FAD By similarity
	Binding site	320	1	FAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	A4VXW3 [UniParc]. Last modified May 29, 2007. Version 1. Checksum: 26C48C9D65A8267F	FASTA	322	35,109
	10 20 30 40 50 60 MTQVYDITII GGGPVGLFAA FYAHLRQAKV KIIDSLPQLG GQPAILYPEK AILDIPAFPS 70 80 90 100 110 120 LTGQELTDNL LAQLAPFDTT ICLNETLTAI EPGETITLTT NKGNHQTKTL IIAMGGGAFK 130 140 150 160 170 180 PRPLEIDGAD SFDNVHYHVS NIQQYADKDI VVLGGGDSAV DWSLAFEKIA KTTQIIHRRD 190 200 210 220 230 240 NFRALEHSVE ELKQSSVTIH TPFIPKGLSG ENGRASAIDF DKVKSEDKLT LSFDHLFVNY 250 260 270 280 290 300 GFKSSVGTLK EWGLELNRHR IVVNSKQETS VPGIYAIGDC CFYEGKIDLI ATGLGEAPTA 310 320 VNNAMNYLNP NEKVQPKHST SL

References

[1]

"A glimpse of streptococcal toxic shock syndrome from comparative genomics of S. suis 2 Chinese isolates." Chen C., Tang J., Dong W., Wang C., Feng Y., Wang J., Zheng F., Pan X., Liu D., Li M., Song Y., Zhu X., Sun H., Feng T., Guo Z., Ju A., Ge J., Dong Y. , Sun W., Jiang Y., Wang J., Yan J., Yang H., Wang X., Gao G.F., Yang R., Wang J., Yu J. PLoS ONE 2:E315-E315(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 05ZYH33.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000407 Genomic DNA. Translation: ABP90952.1.
RefSeq	YP_001199352.1. NC_009442.1.
3D structure databases
ProteinModelPortal	A4VXW3.
ModBase	Search...
Protein-protein interaction databases
STRING	391295.SSU05_1986.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABP90952; ABP90952; SSU05_1986.
GeneID	5100010.
KEGG	ssu:SSU05_1986.
PATRIC	19775724. VBIStrSui128929_1955.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0492.
HOGENOM	HOG000072909.
KO	K00384.
OMA	WALMLEP.
ProtClustDB	CLSK884118.
Family and domain databases
HAMAP	MF_01685. FENR2.
InterPro	IPR013027. FAD_pyr_nucl-diS_OxRdtase. IPR022890. Fd--NADP_Rdtase_type_2. IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD. IPR001327. Pyr_OxRdtase_NAD-bd_dom. IPR000103. Pyridine_nuc-diS_OxRdtase_2. [Graphical view]
Pfam	PF00070. Pyr_redox. 1 hit. PF07992. Pyr_redox_2. 1 hit. [Graphical view]
PRINTS	PR00368. FADPNR. PR00469. PNDRDTASEII.
ProtoNet	Search...

Entry information

Entry name

FENR_STRSY

Accession

Primary (citable) accession number: A4VXW3

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 3, 2009
Last sequence update:	May 29, 2007
Last modified:	May 1, 2013
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program