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Protein

Ferredoxin--NADP reductase

Gene

SSU05_1986

Organism
Streptococcus suis (strain 05ZYH33)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

2 reduced ferredoxin + NADP+ + H+ = 2 oxidized ferredoxin + NADPH.UniRule annotation

Cofactori

FADUniRule annotationNote: Binds 1 FAD per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei34 – 341FADUniRule annotation
Binding sitei42 – 421FADUniRule annotation
Binding sitei47 – 471FADUniRule annotation
Binding sitei87 – 871FAD; via amide nitrogen and carbonyl oxygenUniRule annotation
Binding sitei119 – 1191FAD; via amide nitrogenUniRule annotation
Binding sitei279 – 2791FADUniRule annotation
Binding sitei320 – 3201FADUniRule annotation

GO - Molecular functioni

  1. ferredoxin-NADP+ reductase activity Source: UniProtKB-HAMAP
  2. flavin adenine dinucleotide binding Source: UniProtKB-HAMAP
  3. NADP binding Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein, NADP

Enzyme and pathway databases

BioCyciSSUI391295:GHI8-2046-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ferredoxin--NADP reductaseUniRule annotation (EC:1.18.1.2UniRule annotation)
Short name:
FNRUniRule annotation
Short name:
Fd-NADP(+) reductaseUniRule annotation
Gene namesi
Ordered Locus Names:SSU05_1986
OrganismiStreptococcus suis (strain 05ZYH33)
Taxonomic identifieri391295 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000000243: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 322322Ferredoxin--NADP reductasePRO_0000364974Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi391295.SSU05_1986.

Structurei

3D structure databases

ProteinModelPortaliA4VXW3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ferredoxin--NADP reductase type 2 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0492.
HOGENOMiHOG000072909.
KOiK00384.
OMAiVIVNFGF.
OrthoDBiEOG661H9M.

Family and domain databases

HAMAPiMF_01685. FENR2.
InterProiIPR013027. FAD_pyr_nucl-diS_OxRdtase.
IPR022890. Fd--NADP_Rdtase_type_2.
IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD.
IPR001327. Pyr_OxRdtase_NAD-bd_dom.
IPR000103. Pyridine_nuc-diS_OxRdtase_2.
[Graphical view]
PfamiPF00070. Pyr_redox. 1 hit.
PF07992. Pyr_redox_2. 1 hit.
[Graphical view]
PRINTSiPR00368. FADPNR.
PR00469. PNDRDTASEII.

Sequencei

Sequence statusi: Complete.

A4VXW3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQVYDITII GGGPVGLFAA FYAHLRQAKV KIIDSLPQLG GQPAILYPEK
60 70 80 90 100
AILDIPAFPS LTGQELTDNL LAQLAPFDTT ICLNETLTAI EPGETITLTT
110 120 130 140 150
NKGNHQTKTL IIAMGGGAFK PRPLEIDGAD SFDNVHYHVS NIQQYADKDI
160 170 180 190 200
VVLGGGDSAV DWSLAFEKIA KTTQIIHRRD NFRALEHSVE ELKQSSVTIH
210 220 230 240 250
TPFIPKGLSG ENGRASAIDF DKVKSEDKLT LSFDHLFVNY GFKSSVGTLK
260 270 280 290 300
EWGLELNRHR IVVNSKQETS VPGIYAIGDC CFYEGKIDLI ATGLGEAPTA
310 320
VNNAMNYLNP NEKVQPKHST SL
Length:322
Mass (Da):35,109
Last modified:May 29, 2007 - v1
Checksum:i26C48C9D65A8267F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000407 Genomic DNA. Translation: ABP90952.1.
RefSeqiYP_001199352.1. NC_009442.1.

Genome annotation databases

EnsemblBacteriaiABP90952; ABP90952; SSU05_1986.
GeneIDi5100010.
KEGGissu:SSU05_1986.
PATRICi19775724. VBIStrSui128929_1955.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000407 Genomic DNA. Translation: ABP90952.1.
RefSeqiYP_001199352.1. NC_009442.1.

3D structure databases

ProteinModelPortaliA4VXW3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi391295.SSU05_1986.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABP90952; ABP90952; SSU05_1986.
GeneIDi5100010.
KEGGissu:SSU05_1986.
PATRICi19775724. VBIStrSui128929_1955.

Phylogenomic databases

eggNOGiCOG0492.
HOGENOMiHOG000072909.
KOiK00384.
OMAiVIVNFGF.
OrthoDBiEOG661H9M.

Enzyme and pathway databases

BioCyciSSUI391295:GHI8-2046-MONOMER.

Family and domain databases

HAMAPiMF_01685. FENR2.
InterProiIPR013027. FAD_pyr_nucl-diS_OxRdtase.
IPR022890. Fd--NADP_Rdtase_type_2.
IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD.
IPR001327. Pyr_OxRdtase_NAD-bd_dom.
IPR000103. Pyridine_nuc-diS_OxRdtase_2.
[Graphical view]
PfamiPF00070. Pyr_redox. 1 hit.
PF07992. Pyr_redox_2. 1 hit.
[Graphical view]
PRINTSiPR00368. FADPNR.
PR00469. PNDRDTASEII.
ProtoNetiSearch...

Publicationsi

  1. "A glimpse of streptococcal toxic shock syndrome from comparative genomics of S. suis 2 Chinese isolates."
    Chen C., Tang J., Dong W., Wang C., Feng Y., Wang J., Zheng F., Pan X., Liu D., Li M., Song Y., Zhu X., Sun H., Feng T., Guo Z., Ju A., Ge J., Dong Y.
    , Sun W., Jiang Y., Wang J., Yan J., Yang H., Wang X., Gao G.F., Yang R., Wang J., Yu J.
    PLoS ONE 2:E315-E315(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 05ZYH33.

Entry informationi

Entry nameiFENR_STRSY
AccessioniPrimary (citable) accession number: A4VXW3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: May 29, 2007
Last modified: January 7, 2015
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.