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A4VVI4 (UXUA_STRSY) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mannonate dehydratase

EC=4.2.1.8
Alternative name(s):
D-mannonate hydro-lyase
Gene names
Name:uxuA
Ordered Locus Names:SSU05_1157
OrganismStreptococcus suis (strain 05ZYH33) [Complete proteome] [HAMAP]
Taxonomic identifier391295 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Protein attributes

Sequence length366 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the dehydration of D-mannonate By similarity. HAMAP-Rule MF_00106

Catalytic activity

D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O. HAMAP-Rule MF_00106

Cofactor

Fe2+ or Mn2+ ion By similarity. HAMAP-Rule MF_00106

Pathway

Carbohydrate metabolism; pentose and glucuronate interconversion. HAMAP-Rule MF_00106

Sequence similarities

Belongs to the mannonate dehydratase family.

Ontologies

Keywords
   LigandIron
Manganese
   Molecular functionLyase
   Technical term3D-structure
Complete proteome
Gene Ontology (GO)
   Biological_processglucuronate catabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionmannonate dehydratase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 366366Mannonate dehydratase HAMAP-Rule MF_00106
PRO_1000034339

Secondary structure

......................................................... 366
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
A4VVI4 [UniParc].

Last modified May 29, 2007. Version 1.
Checksum: 9B3C03219A117886

FASTA36640,808
        10         20         30         40         50         60 
MKMSFRWYGK KDPVTLEEIK AIPGMQGIVT AVYDVPVGQA WPLENILELK KMVEEAGLEI 

        70         80         90        100        110        120 
TVIESIPVHE DIKQGKPNRD ALIENYKTSI RNVGAAGIPV VCYNFMPVFD WTRSDLHHPL 

       130        140        150        160        170        180 
PDGSTSLAFL KSDLAGVDPV ADDLNLPGWD SSYSKEEMKA IIENYRQNIS EEDLWANLEY 

       190        200        210        220        230        240 
FIKAILPTAE EAGVKMAIHP DDPPYGIFGL PRIITGQEAV ERFLNLYDSE HNGITMCVGS 

       250        260        270        280        290        300 
YASDPKNDVL AMTEYALKRN RINFMHTRNV TAGAWGFQET AHLSQAGDID MNAVVKLLVD 

       310        320        330        340        350        360 
YDWQGSLRPD HGRRIWGDQT KTPGYGLYDR ALGATYFNGL YEANMRAAGK TPDFGIKAKT 


VGTKEG 

« Hide

References

[1]"A glimpse of streptococcal toxic shock syndrome from comparative genomics of S. suis 2 Chinese isolates."
Chen C., Tang J., Dong W., Wang C., Feng Y., Wang J., Zheng F., Pan X., Liu D., Li M., Song Y., Zhu X., Sun H., Feng T., Guo Z., Ju A., Ge J., Dong Y. expand/collapse author list , Sun W., Jiang Y., Wang J., Yan J., Yang H., Wang X., Gao G.F., Yang R., Wang J., Yu J.
PLoS ONE 2:E315-E315(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 05ZYH33.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000407 Genomic DNA. Translation: ABP90123.1.
RefSeqYP_001198523.1. NC_009442.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3BANX-ray2.90A/B1-366[»]
3BDKX-ray2.50A/B1-366[»]
3DBNX-ray2.90A/B1-366[»]
3FVMX-ray2.90A/B1-366[»]
ProteinModelPortalA4VVI4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING391295.SSU05_1157.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABP90123; ABP90123; SSU05_1157.
GeneID5099758.
KEGGssu:SSU05_1157.
PATRIC19774071. VBIStrSui128929_1133.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1312.
HOGENOMHOG000195381.
KOK01686.
OMAIPNGQVW.
OrthoDBEOG6ZSP6Z.

Enzyme and pathway databases

BioCycSSUI391295:GHI8-1217-MONOMER.
UniPathwayUPA00246.

Family and domain databases

Gene3D3.20.20.150. 1 hit.
HAMAPMF_00106. UxuA.
InterProIPR004628. Man_deHydtase.
IPR013022. Xyl_isomerase-like_TIM-brl.
[Graphical view]
PfamPF03786. UxuA. 1 hit.
[Graphical view]
PIRSFPIRSF016049. Man_dehyd. 1 hit.
SUPFAMSSF51658. SSF51658. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceA4VVI4.

Entry information

Entry nameUXUA_STRSY
AccessionPrimary (citable) accession number: A4VVI4
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 29, 2007
Last modified: May 14, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

PATHWAY comments

Index of metabolic and biosynthesis pathways