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A4VVI4

- UXUA_STRSY

UniProt

A4VVI4 - UXUA_STRSY

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Protein

Mannonate dehydratase

Gene

uxuA

Organism
Streptococcus suis (strain 05ZYH33)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Catalyzes the dehydration of D-mannonate.UniRule annotation

Catalytic activityi

D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O.UniRule annotation

Cofactori

Fe2+ or Mn2+ ion.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. mannonate dehydratase activity Source: UniProtKB-EC

GO - Biological processi

  1. glucuronate catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

Iron, Manganese

Enzyme and pathway databases

BioCyciSSUI391295:GHI8-1217-MONOMER.
UniPathwayiUPA00246.

Names & Taxonomyi

Protein namesi
Recommended name:
Mannonate dehydrataseUniRule annotation (EC:4.2.1.8UniRule annotation)
Alternative name(s):
D-mannonate hydro-lyaseUniRule annotation
Gene namesi
Name:uxuAUniRule annotation
Ordered Locus Names:SSU05_1157
OrganismiStreptococcus suis (strain 05ZYH33)
Taxonomic identifieri391295 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000000243: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 366366Mannonate dehydratasePRO_1000034339Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi391295.SSU05_1157.

Structurei

Secondary structure

1
366
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi4 – 63Combined sources
Helixi16 – 205Combined sources
Beta strandi27 – 304Combined sources
Beta strandi37 – 393Combined sources
Helixi43 – 5412Combined sources
Turni55 – 573Combined sources
Beta strandi59 – 646Combined sources
Helixi70 – 734Combined sources
Helixi79 – 9416Combined sources
Turni95 – 973Combined sources
Beta strandi100 – 1034Combined sources
Beta strandi114 – 1196Combined sources
Beta strandi125 – 1306Combined sources
Helixi131 – 1344Combined sources
Helixi156 – 16712Combined sources
Helixi171 – 19020Combined sources
Beta strandi191 – 1933Combined sources
Beta strandi195 – 1984Combined sources
Beta strandi202 – 2054Combined sources
Helixi217 – 2259Combined sources
Beta strandi232 – 2376Combined sources
Helixi238 – 2425Combined sources
Helixi249 – 25810Combined sources
Beta strandi262 – 2665Combined sources
Beta strandi270 – 2734Combined sources
Beta strandi276 – 2794Combined sources
Helixi284 – 2863Combined sources
Beta strandi287 – 2893Combined sources
Helixi291 – 30010Combined sources
Beta strandi305 – 3084Combined sources
Helixi328 – 34821Combined sources

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3BANX-ray2.90A/B1-366[»]
3BDKX-ray2.50A/B1-366[»]
3DBNX-ray2.90A/B1-366[»]
3FVMX-ray2.90A/B1-366[»]
ProteinModelPortaliA4VVI4.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiA4VVI4.

Family & Domainsi

Sequence similaritiesi

Belongs to the mannonate dehydratase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1312.
HOGENOMiHOG000195381.
KOiK01686.
OMAiIPNGQVW.
OrthoDBiEOG6ZSP6Z.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00106. UxuA.
InterProiIPR004628. Man_deHydtase.
IPR013022. Xyl_isomerase-like_TIM-brl.
[Graphical view]
PfamiPF03786. UxuA. 1 hit.
[Graphical view]
PIRSFiPIRSF016049. Man_dehyd. 1 hit.
SUPFAMiSSF51658. SSF51658. 1 hit.

Sequencei

Sequence statusi: Complete.

A4VVI4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKMSFRWYGK KDPVTLEEIK AIPGMQGIVT AVYDVPVGQA WPLENILELK
60 70 80 90 100
KMVEEAGLEI TVIESIPVHE DIKQGKPNRD ALIENYKTSI RNVGAAGIPV
110 120 130 140 150
VCYNFMPVFD WTRSDLHHPL PDGSTSLAFL KSDLAGVDPV ADDLNLPGWD
160 170 180 190 200
SSYSKEEMKA IIENYRQNIS EEDLWANLEY FIKAILPTAE EAGVKMAIHP
210 220 230 240 250
DDPPYGIFGL PRIITGQEAV ERFLNLYDSE HNGITMCVGS YASDPKNDVL
260 270 280 290 300
AMTEYALKRN RINFMHTRNV TAGAWGFQET AHLSQAGDID MNAVVKLLVD
310 320 330 340 350
YDWQGSLRPD HGRRIWGDQT KTPGYGLYDR ALGATYFNGL YEANMRAAGK
360
TPDFGIKAKT VGTKEG
Length:366
Mass (Da):40,808
Last modified:May 29, 2007 - v1
Checksum:i9B3C03219A117886
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000407 Genomic DNA. Translation: ABP90123.1.
RefSeqiYP_001198523.1. NC_009442.1.

Genome annotation databases

EnsemblBacteriaiABP90123; ABP90123; SSU05_1157.
GeneIDi5099758.
KEGGissu:SSU05_1157.
PATRICi19774071. VBIStrSui128929_1133.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000407 Genomic DNA. Translation: ABP90123.1 .
RefSeqi YP_001198523.1. NC_009442.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3BAN X-ray 2.90 A/B 1-366 [» ]
3BDK X-ray 2.50 A/B 1-366 [» ]
3DBN X-ray 2.90 A/B 1-366 [» ]
3FVM X-ray 2.90 A/B 1-366 [» ]
ProteinModelPortali A4VVI4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 391295.SSU05_1157.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABP90123 ; ABP90123 ; SSU05_1157 .
GeneIDi 5099758.
KEGGi ssu:SSU05_1157.
PATRICi 19774071. VBIStrSui128929_1133.

Phylogenomic databases

eggNOGi COG1312.
HOGENOMi HOG000195381.
KOi K01686.
OMAi IPNGQVW.
OrthoDBi EOG6ZSP6Z.

Enzyme and pathway databases

UniPathwayi UPA00246 .
BioCyci SSUI391295:GHI8-1217-MONOMER.

Miscellaneous databases

EvolutionaryTracei A4VVI4.

Family and domain databases

Gene3Di 3.20.20.150. 1 hit.
HAMAPi MF_00106. UxuA.
InterProi IPR004628. Man_deHydtase.
IPR013022. Xyl_isomerase-like_TIM-brl.
[Graphical view ]
Pfami PF03786. UxuA. 1 hit.
[Graphical view ]
PIRSFi PIRSF016049. Man_dehyd. 1 hit.
SUPFAMi SSF51658. SSF51658. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "A glimpse of streptococcal toxic shock syndrome from comparative genomics of S. suis 2 Chinese isolates."
    Chen C., Tang J., Dong W., Wang C., Feng Y., Wang J., Zheng F., Pan X., Liu D., Li M., Song Y., Zhu X., Sun H., Feng T., Guo Z., Ju A., Ge J., Dong Y.
    , Sun W., Jiang Y., Wang J., Yan J., Yang H., Wang X., Gao G.F., Yang R., Wang J., Yu J.
    PLoS ONE 2:E315-E315(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 05ZYH33.

Entry informationi

Entry nameiUXUA_STRSY
AccessioniPrimary (citable) accession number: A4VVI4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 29, 2007
Last modified: October 29, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3