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A4VVI4

- UXUA_STRSY

UniProt

A4VVI4 - UXUA_STRSY

Protein

Mannonate dehydratase

Gene

uxuA

Organism
Streptococcus suis (strain 05ZYH33)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 1 (29 May 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the dehydration of D-mannonate.UniRule annotation

    Catalytic activityi

    D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O.UniRule annotation

    Cofactori

    Fe2+ or Mn2+ ion.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. mannonate dehydratase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glucuronate catabolic process Source: InterPro

    Keywords - Molecular functioni

    Lyase

    Keywords - Ligandi

    Iron, Manganese

    Enzyme and pathway databases

    BioCyciSSUI391295:GHI8-1217-MONOMER.
    UniPathwayiUPA00246.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mannonate dehydrataseUniRule annotation (EC:4.2.1.8UniRule annotation)
    Alternative name(s):
    D-mannonate hydro-lyaseUniRule annotation
    Gene namesi
    Name:uxuAUniRule annotation
    Ordered Locus Names:SSU05_1157
    OrganismiStreptococcus suis (strain 05ZYH33)
    Taxonomic identifieri391295 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000000243: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 366366Mannonate dehydratasePRO_1000034339Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi391295.SSU05_1157.

    Structurei

    Secondary structure

    1
    366
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi4 – 63
    Helixi16 – 205
    Beta strandi27 – 304
    Beta strandi37 – 393
    Helixi43 – 5412
    Turni55 – 573
    Beta strandi59 – 646
    Helixi70 – 734
    Helixi79 – 9416
    Turni95 – 973
    Beta strandi100 – 1034
    Beta strandi114 – 1196
    Beta strandi125 – 1306
    Helixi131 – 1344
    Helixi156 – 16712
    Helixi171 – 19020
    Beta strandi191 – 1933
    Beta strandi195 – 1984
    Beta strandi202 – 2054
    Helixi217 – 2259
    Beta strandi232 – 2376
    Helixi238 – 2425
    Helixi249 – 25810
    Beta strandi262 – 2665
    Beta strandi270 – 2734
    Beta strandi276 – 2794
    Helixi284 – 2863
    Beta strandi287 – 2893
    Helixi291 – 30010
    Beta strandi305 – 3084
    Helixi328 – 34821

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3BANX-ray2.90A/B1-366[»]
    3BDKX-ray2.50A/B1-366[»]
    3DBNX-ray2.90A/B1-366[»]
    3FVMX-ray2.90A/B1-366[»]
    ProteinModelPortaliA4VVI4.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiA4VVI4.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the mannonate dehydratase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1312.
    HOGENOMiHOG000195381.
    KOiK01686.
    OMAiIPNGQVW.
    OrthoDBiEOG6ZSP6Z.

    Family and domain databases

    Gene3Di3.20.20.150. 1 hit.
    HAMAPiMF_00106. UxuA.
    InterProiIPR004628. Man_deHydtase.
    IPR013022. Xyl_isomerase-like_TIM-brl.
    [Graphical view]
    PfamiPF03786. UxuA. 1 hit.
    [Graphical view]
    PIRSFiPIRSF016049. Man_dehyd. 1 hit.
    SUPFAMiSSF51658. SSF51658. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A4VVI4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKMSFRWYGK KDPVTLEEIK AIPGMQGIVT AVYDVPVGQA WPLENILELK    50
    KMVEEAGLEI TVIESIPVHE DIKQGKPNRD ALIENYKTSI RNVGAAGIPV 100
    VCYNFMPVFD WTRSDLHHPL PDGSTSLAFL KSDLAGVDPV ADDLNLPGWD 150
    SSYSKEEMKA IIENYRQNIS EEDLWANLEY FIKAILPTAE EAGVKMAIHP 200
    DDPPYGIFGL PRIITGQEAV ERFLNLYDSE HNGITMCVGS YASDPKNDVL 250
    AMTEYALKRN RINFMHTRNV TAGAWGFQET AHLSQAGDID MNAVVKLLVD 300
    YDWQGSLRPD HGRRIWGDQT KTPGYGLYDR ALGATYFNGL YEANMRAAGK 350
    TPDFGIKAKT VGTKEG 366
    Length:366
    Mass (Da):40,808
    Last modified:May 29, 2007 - v1
    Checksum:i9B3C03219A117886
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000407 Genomic DNA. Translation: ABP90123.1.
    RefSeqiYP_001198523.1. NC_009442.1.

    Genome annotation databases

    EnsemblBacteriaiABP90123; ABP90123; SSU05_1157.
    GeneIDi5099758.
    KEGGissu:SSU05_1157.
    PATRICi19774071. VBIStrSui128929_1133.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000407 Genomic DNA. Translation: ABP90123.1 .
    RefSeqi YP_001198523.1. NC_009442.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3BAN X-ray 2.90 A/B 1-366 [» ]
    3BDK X-ray 2.50 A/B 1-366 [» ]
    3DBN X-ray 2.90 A/B 1-366 [» ]
    3FVM X-ray 2.90 A/B 1-366 [» ]
    ProteinModelPortali A4VVI4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 391295.SSU05_1157.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABP90123 ; ABP90123 ; SSU05_1157 .
    GeneIDi 5099758.
    KEGGi ssu:SSU05_1157.
    PATRICi 19774071. VBIStrSui128929_1133.

    Phylogenomic databases

    eggNOGi COG1312.
    HOGENOMi HOG000195381.
    KOi K01686.
    OMAi IPNGQVW.
    OrthoDBi EOG6ZSP6Z.

    Enzyme and pathway databases

    UniPathwayi UPA00246 .
    BioCyci SSUI391295:GHI8-1217-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei A4VVI4.

    Family and domain databases

    Gene3Di 3.20.20.150. 1 hit.
    HAMAPi MF_00106. UxuA.
    InterProi IPR004628. Man_deHydtase.
    IPR013022. Xyl_isomerase-like_TIM-brl.
    [Graphical view ]
    Pfami PF03786. UxuA. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF016049. Man_dehyd. 1 hit.
    SUPFAMi SSF51658. SSF51658. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "A glimpse of streptococcal toxic shock syndrome from comparative genomics of S. suis 2 Chinese isolates."
      Chen C., Tang J., Dong W., Wang C., Feng Y., Wang J., Zheng F., Pan X., Liu D., Li M., Song Y., Zhu X., Sun H., Feng T., Guo Z., Ju A., Ge J., Dong Y.
      , Sun W., Jiang Y., Wang J., Yan J., Yang H., Wang X., Gao G.F., Yang R., Wang J., Yu J.
      PLoS ONE 2:E315-E315(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 05ZYH33.

    Entry informationi

    Entry nameiUXUA_STRSY
    AccessioniPrimary (citable) accession number: A4VVI4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: May 29, 2007
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3