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Protein

Mannonate dehydratase

Gene

uxuA

Organism
Streptococcus suis (strain 05ZYH33)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the dehydration of D-mannonate.UniRule annotation

Catalytic activityi

D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O.UniRule annotation

Cofactori

Fe2+UniRule annotation, Mn2+UniRule annotation

Pathwayi

GO - Molecular functioni

  1. mannonate dehydratase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. glucuronate catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

Iron, Manganese

Enzyme and pathway databases

BioCyciSSUI391295:GHI8-1217-MONOMER.
BRENDAi4.2.1.8. 7186.
UniPathwayiUPA00246.

Names & Taxonomyi

Protein namesi
Recommended name:
Mannonate dehydrataseUniRule annotation (EC:4.2.1.8UniRule annotation)
Alternative name(s):
D-mannonate hydro-lyaseUniRule annotation
Gene namesi
Name:uxuAUniRule annotation
Ordered Locus Names:SSU05_1157
OrganismiStreptococcus suis (strain 05ZYH33)
Taxonomic identifieri391295 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000000243 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 366366Mannonate dehydratasePRO_1000034339Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi391295.SSU05_1157.

Structurei

Secondary structure

1
366
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi4 – 63Combined sources
Helixi16 – 205Combined sources
Beta strandi27 – 304Combined sources
Beta strandi37 – 393Combined sources
Helixi43 – 5412Combined sources
Turni55 – 573Combined sources
Beta strandi59 – 646Combined sources
Helixi70 – 734Combined sources
Helixi79 – 9416Combined sources
Turni95 – 973Combined sources
Beta strandi100 – 1034Combined sources
Beta strandi114 – 1196Combined sources
Beta strandi125 – 1306Combined sources
Helixi131 – 1344Combined sources
Helixi156 – 16712Combined sources
Helixi171 – 19020Combined sources
Beta strandi191 – 1933Combined sources
Beta strandi195 – 1984Combined sources
Beta strandi202 – 2054Combined sources
Helixi217 – 2259Combined sources
Beta strandi232 – 2376Combined sources
Helixi238 – 2425Combined sources
Helixi249 – 25810Combined sources
Beta strandi262 – 2665Combined sources
Beta strandi270 – 2734Combined sources
Beta strandi276 – 2794Combined sources
Helixi284 – 2863Combined sources
Beta strandi287 – 2893Combined sources
Helixi291 – 30010Combined sources
Beta strandi305 – 3084Combined sources
Helixi328 – 34821Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3BANX-ray2.90A/B1-366[»]
3BDKX-ray2.50A/B1-366[»]
3DBNX-ray2.90A/B1-366[»]
3FVMX-ray2.90A/B1-366[»]
ProteinModelPortaliA4VVI4.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiA4VVI4.

Family & Domainsi

Sequence similaritiesi

Belongs to the mannonate dehydratase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1312.
HOGENOMiHOG000195381.
KOiK01686.
OMAiFASRTHF.
OrthoDBiEOG6ZSP6Z.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00106. UxuA.
InterProiIPR004628. Man_deHydtase.
IPR013022. Xyl_isomerase-like_TIM-brl.
[Graphical view]
PfamiPF03786. UxuA. 1 hit.
[Graphical view]
SUPFAMiSSF51658. SSF51658. 1 hit.

Sequencei

Sequence statusi: Complete.

A4VVI4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKMSFRWYGK KDPVTLEEIK AIPGMQGIVT AVYDVPVGQA WPLENILELK
60 70 80 90 100
KMVEEAGLEI TVIESIPVHE DIKQGKPNRD ALIENYKTSI RNVGAAGIPV
110 120 130 140 150
VCYNFMPVFD WTRSDLHHPL PDGSTSLAFL KSDLAGVDPV ADDLNLPGWD
160 170 180 190 200
SSYSKEEMKA IIENYRQNIS EEDLWANLEY FIKAILPTAE EAGVKMAIHP
210 220 230 240 250
DDPPYGIFGL PRIITGQEAV ERFLNLYDSE HNGITMCVGS YASDPKNDVL
260 270 280 290 300
AMTEYALKRN RINFMHTRNV TAGAWGFQET AHLSQAGDID MNAVVKLLVD
310 320 330 340 350
YDWQGSLRPD HGRRIWGDQT KTPGYGLYDR ALGATYFNGL YEANMRAAGK
360
TPDFGIKAKT VGTKEG
Length:366
Mass (Da):40,808
Last modified:May 28, 2007 - v1
Checksum:i9B3C03219A117886
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000407 Genomic DNA. Translation: ABP90123.1.
RefSeqiYP_001198523.1. NC_009442.1.

Genome annotation databases

EnsemblBacteriaiABP90123; ABP90123; SSU05_1157.
GeneIDi5099758.
KEGGissu:SSU05_1157.
PATRICi19774071. VBIStrSui128929_1133.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000407 Genomic DNA. Translation: ABP90123.1.
RefSeqiYP_001198523.1. NC_009442.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3BANX-ray2.90A/B1-366[»]
3BDKX-ray2.50A/B1-366[»]
3DBNX-ray2.90A/B1-366[»]
3FVMX-ray2.90A/B1-366[»]
ProteinModelPortaliA4VVI4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi391295.SSU05_1157.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABP90123; ABP90123; SSU05_1157.
GeneIDi5099758.
KEGGissu:SSU05_1157.
PATRICi19774071. VBIStrSui128929_1133.

Phylogenomic databases

eggNOGiCOG1312.
HOGENOMiHOG000195381.
KOiK01686.
OMAiFASRTHF.
OrthoDBiEOG6ZSP6Z.

Enzyme and pathway databases

UniPathwayiUPA00246.
BioCyciSSUI391295:GHI8-1217-MONOMER.
BRENDAi4.2.1.8. 7186.

Miscellaneous databases

EvolutionaryTraceiA4VVI4.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00106. UxuA.
InterProiIPR004628. Man_deHydtase.
IPR013022. Xyl_isomerase-like_TIM-brl.
[Graphical view]
PfamiPF03786. UxuA. 1 hit.
[Graphical view]
SUPFAMiSSF51658. SSF51658. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "A glimpse of streptococcal toxic shock syndrome from comparative genomics of S. suis 2 Chinese isolates."
    Chen C., Tang J., Dong W., Wang C., Feng Y., Wang J., Zheng F., Pan X., Liu D., Li M., Song Y., Zhu X., Sun H., Feng T., Guo Z., Ju A., Ge J., Dong Y.
    , Sun W., Jiang Y., Wang J., Yan J., Yang H., Wang X., Gao G.F., Yang R., Wang J., Yu J.
    PLoS ONE 2:E315-E315(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 05ZYH33.

Entry informationi

Entry nameiUXUA_STRSY
AccessioniPrimary (citable) accession number: A4VVI4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 14, 2008
Last sequence update: May 28, 2007
Last modified: March 31, 2015
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.