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Protein

Mannonate dehydratase

Gene

uxuA

Organism
Streptococcus suis (strain 05ZYH33)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the dehydration of D-mannonate.UniRule annotation

Catalytic activityi

D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O.UniRule annotation

Cofactori

Fe2+UniRule annotation, Mn2+UniRule annotation

Pathwayi: pentose and glucuronate interconversion

This protein is involved in the pathway pentose and glucuronate interconversion, which is part of Carbohydrate metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway pentose and glucuronate interconversion and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

Iron, Manganese

Enzyme and pathway databases

BRENDAi4.2.1.8. 7186.
UniPathwayiUPA00246.

Names & Taxonomyi

Protein namesi
Recommended name:
Mannonate dehydrataseUniRule annotation (EC:4.2.1.8UniRule annotation)
Alternative name(s):
D-mannonate hydro-lyaseUniRule annotation
Gene namesi
Name:uxuAUniRule annotation
Ordered Locus Names:SSU05_1157
OrganismiStreptococcus suis (strain 05ZYH33)
Taxonomic identifieri391295 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000000243 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000343391 – 366Mannonate dehydrataseAdd BLAST366

Interactioni

Protein-protein interaction databases

STRINGi391295.SSU05_1157.

Structurei

Secondary structure

1366
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi4 – 6Combined sources3
Helixi16 – 20Combined sources5
Beta strandi27 – 30Combined sources4
Beta strandi37 – 39Combined sources3
Helixi43 – 54Combined sources12
Turni55 – 57Combined sources3
Beta strandi59 – 64Combined sources6
Helixi70 – 73Combined sources4
Helixi79 – 94Combined sources16
Turni95 – 97Combined sources3
Beta strandi100 – 103Combined sources4
Beta strandi114 – 119Combined sources6
Beta strandi125 – 130Combined sources6
Helixi131 – 134Combined sources4
Helixi156 – 167Combined sources12
Helixi171 – 190Combined sources20
Beta strandi191 – 193Combined sources3
Beta strandi195 – 198Combined sources4
Beta strandi202 – 205Combined sources4
Helixi217 – 225Combined sources9
Beta strandi232 – 237Combined sources6
Helixi238 – 242Combined sources5
Helixi249 – 258Combined sources10
Beta strandi262 – 266Combined sources5
Beta strandi270 – 273Combined sources4
Beta strandi276 – 279Combined sources4
Helixi284 – 286Combined sources3
Beta strandi287 – 289Combined sources3
Helixi291 – 300Combined sources10
Beta strandi305 – 308Combined sources4
Helixi328 – 348Combined sources21

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3BANX-ray2.90A/B1-366[»]
3BDKX-ray2.50A/B1-366[»]
3DBNX-ray2.90A/B1-366[»]
3FVMX-ray2.90A/B1-366[»]
ProteinModelPortaliA4VVI4.
SMRiA4VVI4.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiA4VVI4.

Family & Domainsi

Sequence similaritiesi

Belongs to the mannonate dehydratase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CHZ. Bacteria.
COG1312. LUCA.
HOGENOMiHOG000195381.
KOiK01686.
OMAiESIPVHN.
OrthoDBiPOG091H06MP.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00106. UxuA. 1 hit.
InterProiIPR004628. Man_deHydtase.
IPR013022. Xyl_isomerase-like_TIM-brl.
[Graphical view]
PfamiPF03786. UxuA. 1 hit.
[Graphical view]
SUPFAMiSSF51658. SSF51658. 1 hit.

Sequencei

Sequence statusi: Complete.

A4VVI4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKMSFRWYGK KDPVTLEEIK AIPGMQGIVT AVYDVPVGQA WPLENILELK
60 70 80 90 100
KMVEEAGLEI TVIESIPVHE DIKQGKPNRD ALIENYKTSI RNVGAAGIPV
110 120 130 140 150
VCYNFMPVFD WTRSDLHHPL PDGSTSLAFL KSDLAGVDPV ADDLNLPGWD
160 170 180 190 200
SSYSKEEMKA IIENYRQNIS EEDLWANLEY FIKAILPTAE EAGVKMAIHP
210 220 230 240 250
DDPPYGIFGL PRIITGQEAV ERFLNLYDSE HNGITMCVGS YASDPKNDVL
260 270 280 290 300
AMTEYALKRN RINFMHTRNV TAGAWGFQET AHLSQAGDID MNAVVKLLVD
310 320 330 340 350
YDWQGSLRPD HGRRIWGDQT KTPGYGLYDR ALGATYFNGL YEANMRAAGK
360
TPDFGIKAKT VGTKEG
Length:366
Mass (Da):40,808
Last modified:May 29, 2007 - v1
Checksum:i9B3C03219A117886
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000407 Genomic DNA. Translation: ABP90123.1.

Genome annotation databases

EnsemblBacteriaiABP90123; ABP90123; SSU05_1157.
KEGGissu:SSU05_1157.
PATRICi19774071. VBIStrSui128929_1133.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000407 Genomic DNA. Translation: ABP90123.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3BANX-ray2.90A/B1-366[»]
3BDKX-ray2.50A/B1-366[»]
3DBNX-ray2.90A/B1-366[»]
3FVMX-ray2.90A/B1-366[»]
ProteinModelPortaliA4VVI4.
SMRiA4VVI4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi391295.SSU05_1157.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABP90123; ABP90123; SSU05_1157.
KEGGissu:SSU05_1157.
PATRICi19774071. VBIStrSui128929_1133.

Phylogenomic databases

eggNOGiENOG4105CHZ. Bacteria.
COG1312. LUCA.
HOGENOMiHOG000195381.
KOiK01686.
OMAiESIPVHN.
OrthoDBiPOG091H06MP.

Enzyme and pathway databases

UniPathwayiUPA00246.
BRENDAi4.2.1.8. 7186.

Miscellaneous databases

EvolutionaryTraceiA4VVI4.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00106. UxuA. 1 hit.
InterProiIPR004628. Man_deHydtase.
IPR013022. Xyl_isomerase-like_TIM-brl.
[Graphical view]
PfamiPF03786. UxuA. 1 hit.
[Graphical view]
SUPFAMiSSF51658. SSF51658. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiUXUA_STRSY
AccessioniPrimary (citable) accession number: A4VVI4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 29, 2007
Last modified: November 2, 2016
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.